Sentences with phrase «by much trial»

By much trial and error, I have found the best ways to get the most out of each day.

Not exact matches

In fact, Amgen's Repatha and Sanofi's Praluent, the first of these types of treatments to win approval in the U.S., reduced LDL cholesterol by as much as 60 % in clinical trials.

The new Alzheimer's framework may not be much of a surprise given numerous, high - profile, late - stage clinical trial failures in the field by companies like Eli Lilly and Merck, and the decision by other companies (such as Pfizer) to back away from the risk - prone field.

Take a much - trumpeted 2014 study out of MIT, in which research subjects underwent work trials with both human and robots in charge and found they preferred being managed by the machines.

Therefore, strictly by this definition, the Sanhedrin trial MUST only be so much literary creation.

But it does, by the grace of God, manage to discover enough glimmers of meaning to continue to labor joyously despite great trials, hoping against hope, looking for significant ways to let the «least of these» know how much God loves them.

On the other hand, his narrative of Louverture's tragic end — lured across the Atlantic by Napoleon and then locked away to die in a stone fortress in the Jura without so much as a trial — is told with more pathos than the average academic historian could manage.

How would our faith survive if we were indeed faced by such a trial - and if it did, how much would it be a source of strength?

What this pastor is doing is not much different than what was done by the christians during the Salem Witch Trials or the Crusades or Hitler for that matter.

Medical authorities W. D. Edwards, W. J. Gabel and F. E. Hosmer, much more in tune with medical accuracy than that of correct theology in reference to the Gospels, offer the following analysis in regard to the New Testament Greek and the medical data: «Jesus of Nazareth underwent Jewish and Roman trials, was flogged, and was sentenced to death by crucifixion.

The trial judge also concluded that (para 285) «the threat of sale by independent retailers to the major supermarket chains constrained Metcash's wholesale pricing decisions» and that the competitive constraint imposed by Franklins was much less than that imposed by the major supermarket chains - these findings of the trial judge were set out by Yates J at para 297 as follows:

After much trial and error, he achieved this by combining 2 simple ingredients: fresh fruit and triple - filtered sparkling water.

there are any number of steps that lead to the trial, and much of that is governed by the extra protections cops enjoy within the process.

Receive these plays along with real - time odds from 40 + sportsbooks, public betting trends from 7 contributing sportsbooks and much more by signing up for a 4 - day trial of Sportsbook Insider Pro.

Several trials have also found that sleep training reduces the risk of maternal depression — by as much as a factor of three — which is (actually!)

The jury in the Joe Percoco federal corruption trial resumes its work today, after appearing to focus much of its attention last Friday on the low - show job given to Percoco's wife, Lisa, by a Maryland - based energy company, Competitive Power Ventures, which is behind a controversial new power plant in Orange County.

Next the Foreign Office's lawyers admitted that the three claimants were tortured by the British colonial authorities, but argued that too much time had passed to enable a fair trial.

«Of course, much of what Cuomo has been talking about over the last several weeks has been overshadowed by the ongoing coverage of the Federal corruption trial in Manhattan, in which the Governor has been featured prominently.»

Given how strange and over the top much of the testimony in this trial was, the jurors were probably unfazed by the fact that the prosecutors ended their argument by quoting a Shel Silverstein poem.

NEW YORK — If they hadn't heard about it before, jurors in the Joseph Percoco trial received a briefing Tuesday of the much - criticized system by which state politicians fill their campaign accounts with donations from people with business before state government.

The characteristics of the groups of people chosen to participate in the trials were much more similar than would have happened by chance.

According to Devinsky, 10 to 15 percent of patients with otherwise unmanageable epilepsy are potential candidates for the treatment; clinical trials have shown that the implants reduce seizures in the treated group by an average of as much as 66 percent after three to six years of follow - up.

The researchers note urinary epidermal growth factor has the potential to reduce trial costs by as much as 75 percent, as well as shorten the time until a medicine is widely available to all patients.

But only one published clinical trial has shown that copper lowers infection rates — by as much as 58 % — in hospitals.

Bikes evolved by trial and error, and by the early twentieth century they looked much as they do today.

Or the positioning of the electrodes might have been partially to blame: In a separate study, which began after the BROADEN trial, Mayberg and colleagues discovered that they could improve response rates — by as much as 80 % in 24 patients — by fine - tuning the electrodes» position.

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

If these new results are confirmed by further patient trials, they could soon pave the way for a much needed new treatment for late - stage prostate cancer.»

They estimate that using these algorithms to predict outcomes could allow a drug sponsor to reduce the size of the trial by at least 20 % and save as much as $ 6 million in a large phase III trial.

The report from an international committee convened by the U.S. National Academy of Sciences (NAS) and the National Academy of Medicine in Washington, D.C., concludes that such a clinical trial «might be permitted, but only following much more research» on risks and benefits, and «only for compelling reasons and under strict oversight.»

Meanwhile, a drug that works much the same way — by blocking the beta - arrestin2 pathway while activating the G protein pathway at the mu opioid receptor — is currently in the final stages of human clinical trials.

A much - watched clinical trial on embryonic stem cell therapy for spinal cord injuries was dropped by Menlo Park biotech Geron in 2011.

But Aeras will continue to fight for progress by learning as much as we can from our ongoing trials and research; by sharing scientific gains, building strong partnerships, and making sure that the world hears our call for increased and essential investment in TB vaccine research and development; and by leading the push for innovation, in the lab and beyond.

You might think this means that the strategy was ineffective, but there's an added wrinkle: not surprisingly, the «low» group managed a much feebler effort in their interval sessions (since they were so depleted), but still managed to improve by the same amount on the time trial.

A systematic review of all the dietary trials showed that much of the benefits of a low carbohydrate approach faded by 1 year.In the follow up to the DIRECT study, it was found that by 12 months, weight had started to regain in all patients, including the low carbohydrate group.

By studying (and a lot of trial and error) I have learned how to develop my meal plans in a way that not only enables me to achieve my fitness goals but also makes my diabetes management much easier.

Solanezumab is in the third and final phase of FDA drug trials, and if approved, could bring in at least $ 7.6 billion in sales by 2024 and probably much more.

Much of the research to date has been promising, Smoliga says, but most studies — like those led by Das — involve only laboratory experiments and animal trials.

With the Zodiac killer still very much on the loose, the film decides to double down on its creeping cynicism by suggesting that the only solution is to give more power to the state and do away with basic freedoms such as a fair trial and basic law and order.

Because much like the revolutionary shock troops who seized the United States embassy on Nov. 4, 1979, and turned the crisis into gripping political theater watched by the entire world — tune in tomorrow when America goes on trial, with the special guest star the Ayatollah Khomeini — the producer knows that historical events alone don't cut it.

Joseph Viteritti's Feature essay «Vouchers on Trial» tells us that even a decision allowing the Cleveland program to proceed will be followed by much litigation over the many state - created «walls of separation.»

Uhlenhaut, caught by surprise and intrigued, later drove the car and loved it so much, he took a prototype for an inter-continental sprint around Europe reportedly without trouble — impressive for when reliability was still an effort of much trial and head - scratching.

By Barry Carter / «The Morgans time forgot» — Two survivors of the three - wheelers exported to Australia are described by Dennis Harrison / Archers of Dunmow — In the first of a series of articles on restoration and technical subjects David Hawtin writes about this long - established restoration workshop / 1909 Sizaire - Naudin — The brothers Sizaire and Louis Naudin produced a variety of cars including the example described here by Douglas Ormrod / MG Picnic at Brookiands — Malcolm Green reports on the well - attended picnic for MG enthusiasts in support of the Brookiands Appeal / The English - bodied Stutz — The popularity of Stutz cars in this country in the late 20s is explained by Michael Worthington - Williams / 1929 Stutz straight - eight — The Editor drives a Lancefield - bodied type M in this month's Excursion / Pre-war racing at Donington — Robert Heelis recalls watching motor racing at the Midlands circuit when he was a boy / VSCC Welsh Trial — In his Diary of a dilettante Tom Threlfall reports on this year's Welsh Trial / Rallye des Ancetres — Malcolm Elder tells us how much he enjoyed taking part in this French rallBy Barry Carter / «The Morgans time forgot» — Two survivors of the three - wheelers exported to Australia are described by Dennis Harrison / Archers of Dunmow — In the first of a series of articles on restoration and technical subjects David Hawtin writes about this long - established restoration workshop / 1909 Sizaire - Naudin — The brothers Sizaire and Louis Naudin produced a variety of cars including the example described here by Douglas Ormrod / MG Picnic at Brookiands — Malcolm Green reports on the well - attended picnic for MG enthusiasts in support of the Brookiands Appeal / The English - bodied Stutz — The popularity of Stutz cars in this country in the late 20s is explained by Michael Worthington - Williams / 1929 Stutz straight - eight — The Editor drives a Lancefield - bodied type M in this month's Excursion / Pre-war racing at Donington — Robert Heelis recalls watching motor racing at the Midlands circuit when he was a boy / VSCC Welsh Trial — In his Diary of a dilettante Tom Threlfall reports on this year's Welsh Trial / Rallye des Ancetres — Malcolm Elder tells us how much he enjoyed taking part in this French rallby Dennis Harrison / Archers of Dunmow — In the first of a series of articles on restoration and technical subjects David Hawtin writes about this long - established restoration workshop / 1909 Sizaire - Naudin — The brothers Sizaire and Louis Naudin produced a variety of cars including the example described here by Douglas Ormrod / MG Picnic at Brookiands — Malcolm Green reports on the well - attended picnic for MG enthusiasts in support of the Brookiands Appeal / The English - bodied Stutz — The popularity of Stutz cars in this country in the late 20s is explained by Michael Worthington - Williams / 1929 Stutz straight - eight — The Editor drives a Lancefield - bodied type M in this month's Excursion / Pre-war racing at Donington — Robert Heelis recalls watching motor racing at the Midlands circuit when he was a boy / VSCC Welsh Trial — In his Diary of a dilettante Tom Threlfall reports on this year's Welsh Trial / Rallye des Ancetres — Malcolm Elder tells us how much he enjoyed taking part in this French rallby Douglas Ormrod / MG Picnic at Brookiands — Malcolm Green reports on the well - attended picnic for MG enthusiasts in support of the Brookiands Appeal / The English - bodied Stutz — The popularity of Stutz cars in this country in the late 20s is explained by Michael Worthington - Williams / 1929 Stutz straight - eight — The Editor drives a Lancefield - bodied type M in this month's Excursion / Pre-war racing at Donington — Robert Heelis recalls watching motor racing at the Midlands circuit when he was a boy / VSCC Welsh Trial — In his Diary of a dilettante Tom Threlfall reports on this year's Welsh Trial / Rallye des Ancetres — Malcolm Elder tells us how much he enjoyed taking part in this French rallby Michael Worthington - Williams / 1929 Stutz straight - eight — The Editor drives a Lancefield - bodied type M in this month's Excursion / Pre-war racing at Donington — Robert Heelis recalls watching motor racing at the Midlands circuit when he was a boy / VSCC Welsh Trial — In his Diary of a dilettante Tom Threlfall reports on this year's Welsh Trial / Rallye des Ancetres — Malcolm Elder tells us how much he enjoyed taking part in this French rally.

Mick Walsh gets behind the wheel of an historic Alfa Romeo 8C 2300 and in, Potent Perfection, reveals what makes this famous model so special / Doug Nye shares some marvellous glass - plate negatives from the early days of motor sport in Europe and describes the men and machines shown in The motor racing photography of Maurice - Louis Branger / Famous furniture designer Ambrose Heal bought a Sunbeam Twenty new in 1930 and drove it extensively across Europe / This much - loved car is still in the family today, as Matthew Bell discovers in Family Business / Designed and built by Ken Delingpole and Ron Lowe, the Ford - powered Dellows were among the most successful postwar trials cars.

I'll be talking about Trial by Desire, a book I spent so much time on that even today, the thought of having to look at one word of it make me feel ill to my stomach.

Trial by fire, sure, but likely with much better feedback than your typical rejection letter.

(And those are 30 days of use — by not closing the program or turning off my computer as much as I probably should, I wrote an entire 165k book using the trial version.

The club covered too much territory to be granted trial - giving privileges by the American Kennel Club.

You have to figure out your strategies by trial and error, and there will be much more error.

There are two exceptions, for my money: The Arkham games, since taking down a large group of enemies required such precision and fluidity (though that wasn't DLC, so maybe that doesn't even count) and Dishonored «s much - more - fun - than - I - expected «Dunwall City Trials» which, by focusing purely on individual elements of gameplay, ended up feeling very different from the base game.