Sentences with phrase «ca1 pyramidal cell»

BRAIN CANDY A new database offers a deep look at living human nerve cells, revealing elaborate branching structures and myriad shapes, such as in this neuron called a pyramidal cell (cell image, left and 3 - D computer reconstruction, right).

Long - term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR - A — / — mice when GFPGluR - A expression was constitutive or induced in already fully developed pyramidal cells.

A neuron called a pyramidal cell, for instance, has a bushy branch of dendrites (orange in 3 - D computer reconstruction, above) reaching up from its cell body (white circle).

There is nothing extraneous here in this painting of two pyramidal cells, a type of neuron found in the cerebellum and hippocampus.

Pyramidal cells in the isolated CA1 area developed sharp and stable place fields.

Fast - spiking interneurons are part of a general class of neurons whose primary role is regulating the activity of the principal cells of the cerebral cortex, known as pyramidal cells.

Neuronal activity is correlated with an influx of calcium ions, which can be tracked with fluorescent dyes or proteins that bind to calcium, as in these pyramidal cells.

Along the way the signal can be amplified by excitatory neurons such as pyramidal cells (PYRs) or dampened by inhibitory neurons such as SST and PV cells.

For their analyses, the scientists specifically colored the places of origin of axons of so - called pyramidal cells in the hippocampus.

A significant reduction in the context - specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another.

Neurons communicate with each other through chemical and electrical signals that can be excitatory (activating) or inhibitory (deactivating), depending on their class: Pyramidal cells are excitatory neurons whilst interneurons are inhibitory.

Cembrowski shared some clues as to what's ahead for him and his colleagues: «We have identified suspect number one in terms of what's responsible for the electrophysiological differences between subiculum pyramidal cells and we hope to investigate that, perhaps using gene editing.»

To trace the paths of the pyramidal cells and see if subclasses of cells could be distinguished based on their downstream targets.

In addition, they hope to take the spatial recognition experiments to the next level using a new microscopy technology that could show simultaneous activity in both subclasses of pyramidal cells in a freely moving mouse.

Recently, researchers demonstrated that pyramidal cells may exhibit heterogeneity within the subiculum; in other words, subclasses of these cells may relay different signals to different areas of the brain.

A cross section of the hippocampus with some pyramidal cells depicted with the major incoming fibres (SC - schaffer collaterals, green), TA (temperoammonic pathway, blue), SH (septohippocampal pathway, black) Figure 3.

The gatekeeper (OLM - alpha2; red) counteract signaling coming from the TA pathway (blue), thereby allowing local inputs from the SC pathway (green) on the pyramidal cell (orange) to become stronger.

Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy.

«We found that, during periods of recurrent network activity, cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with the inhibitory potentials synchronously controlling the timing of action potentials.»

The inverse relationship between the amyloid plaque density and pyramidal cell density in the AD brain regions also supports this possibility, as does the close correlation between plaque size and the size of local pyramidal cells.

Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.

A beta 42 first selectively accumulates in the perikaryon of pyramidal cells as discrete, granules that appear to be cathepsin D - positive, suggesting that they may represent lysosomes or lysosome - derived structures.

CONCLUSIONS: Our findings suggest that excessive intracellular accumulation of A beta 42 - positive material in pyramidal cells can result in cell lysis, and that cell lysis is an important source of amyloid plaques and neuronal loss in AD brains.

For her dissertation, Prerana developed several bacTRAP transgenic mouse lines to characterize molecularly distinct cortical pyramidal cell types, and focused on layer 2/3 pyramidal cell population in the prefrontal cortex that moderate stress induced depression related behavior.

Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells.

Jan Mulder, Tania Aguado, Erik Keimpema, Klaudia Barabás, Carlos J. Ballester Rosado, Laurent Nguyen, Krisztina Monory, Giovanni Marsicano, Vincenzo Di Marzo, Yasmin L. Hurd, Francois Guillemo, Ken Mackie, Beat Lutz, Manuel Guzman, Hui - Chen Lu, Ismael Galve - Roperh, Tibor Harkany (2008) «Endocannabinoid signaling controls pyramidal cell specification and corticothalamic axon patterning», Proc Natl Acad Sci U S A, 105:8760 - 8765.

We used extracellular field potential recordings to study BST, short - term plasticity (PTP, post-tetanic potentiation; PPF, paired - pulse facilitation) and long - term potentiation (LTP) at the Schaffer collateral - CA1 pyramidal cell synapses in young and old rTg4510 (2 - 3 and 6 - 7 month old) and old APP / PS1 mice (8 - 10 month old).

Action potentials in brain neuron (hippocampal pyramidal cell) before and after blockade of BK - type (potassium) channels.

Not exact matches

The team, led by CSHL Professor Z. Josh Huang and including researcher Joshua Gordon, M.D., Ph.D., director of the National Institute of Mental Health, focused on dense crowds of excitatory cells called pyramidal neurons — several hundred of which can connect with a single chandelier cell.

The new research reveals how spatially intermixed pyramidal neurons that were associated with single chandelier cells in the mouse prelimbic cortex segregated into two groups.

Because each chandelier cell may control the firing of hundreds of pyramidal neurons, it has been suggested that they exert a kind of «veto» power over local excitatory messages.

A recent generation of studies of postmortem brain tissue from people with schizophrenia, particularly from the laboratory of Professor David Lewis and his colleagues at the University of Pittsburgh, have shed light on schizophrenia - related abnormalities in the interplay of the main excitatory neurons, pyramidal neurons, and a specific class of inhibitory nerve cells, called chandelier cells, in the prefrontal cortex.

It is a complex, highly organised, structure, whose function relies on vast networks containing two main groups of nerve cells, or neurons: pyramidal neurons and interneurons.

To see what was happening in the brains of these ankyrin - G mutant mice, the researchers analyzed the cell components in inhibitory synapses connecting with pyramidal neurons, finding that two proteins known as GAT1 and GAD67 — responsible for making the neurochemical GABA that dials back nerve impulses — were at much lower levels in the synapses on pyramidal neurons in ankyrin - G mutant mice than in normal mice.

They also found that the disruption of the connectivity of these cells during brain development causes alterations in brain oscillatory activity and disturbs the function of place cells, a type of pyramidal neuron that becomes active when an animal is located in a particular place in its environment.