Sentences with phrase «cd44 on the cell surface»

It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

Here, cells expressing the interacting domains of v - and t - SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.

Instead they identified a third way: IL - 6 can also be displayed on the cell surface of dendritic cells and thus be directly presented to T cells.

This interacted with proteins on the cell surface called proteoglycans which led to the nanoparticles being ingested by the cell.

Q1s create the pore that the potassium flows through and the E1s control how slowly that pore opens and closes, how many channels are on the cell surface of each cell and how they are regulated by drugs.

First, it latches onto a receptor on the cell surface.

Various receptors which can either activate or inhibit the cell have been identified on cell surface.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

In particular, it has evolved to show itself three to nine months after infection, allowing its own destruction by displaying antigens on its cell surfaces so the dog's immune system can destroy it.

The good news about the complex interconnectivity is that the scientists also were able to find a potential future point of intervention: When they gave a drug that increased AMPA receptor expression on the cell surface, the spines assumed a more healthy, mature state.

AFM didn't catch the details of microvilli and other structures on the cell surface.

Researchers found that in N. gonorrhoeae, BamE is exposed on the cell surface but is not essential for cell viability.

Researchers already knew that there was a time lag of between 1 and 3 hours between the synthesis of Class II molecules within the APC and their appearance on the cell surface, combined with antigen.

disruption of the cell wall barrier by reactions of chlorine with target sites on the cell surface

Measuring changes in a voltage bias applied to the saline reveals how close the capillary tube is to the cell, allowing researchers to scan subtle structures on the cell surface without disrupting them.

They might also come up with a way to select the right cells out of a mixed population; Anand Swaroop, an ophthalmology researcher at the University of Michigan at Ann Arbor, is working on a way to identify and weed out the photoreceptor cells by focusing on proteins present on cell surfaces.

Cadherin - 22 is located on cell surfaces, allowing hypoxic cancer cells to stick together and migrate collectively as a group, said Uniacke.

Like many other fungi, Baker's yeast has mating receptors, proteins on its cell surface that detect pheromones released by potential partners.

A protein on the cell surface of P. syringae binds water in a way that mimics the structure of an ice crystal, and this helps start the transformation of cold water into ice.

The impulses cause glutamate (one of the brain's main neurotransmitters) to pop out of one nerve cell and travel across the synapse to activate the next by binding to its receptors, chemically active signaling stations on the cell surface.

Plasmodium parasites infect human red blood cells and gain entry via receptors on the cell surface.

This antibody activates an integrin on the cell surface of basal progenitors and thus stimulates their proliferation,» explains Denise Stenzel, who headed the experiments.

(Right) In a liver with HCC, AIM accumulates on the cell surface, resulting in the activation of the complement cascade and inducing necrotic cell death.

Integrins are proteins on the cell surface that attach to and interact with the cell's surroundings.

The team used patterned photoactivation non-linear SIM to produce videos showing structural proteins break down and reassemble themselves as cells move and change shape, as well as the dynamics of tiny pits on cell surfaces called caveolae.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer cases.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

When applied to neurons in cell culture, the antibody locked onto a protein on the cell surface.

«It took us around four years to discover that phthalocyanine, which is a blue paint used on the surface of the Japanese bullet trains and road signs, could bind competitively to the HasA protein,» adds Ms. Chikako Shirataki, a PhD student in her final year, «crystal structures of metal protein complexes helped us to show that the phthalocyanine - bound HasA protein blocks the receptors on the cell surface of the bacterium and thus, inhibits the uptake of heme.»

To identify which structure on the cell surface helped it enter the cell, Raines screened 264 structures using a specially designed chip.

The R117H mutation, carried by about 3 percent the CF population, creates a protein that reaches its destination on the cell surface, but then malfunctions.

«Changes to the sugar composition on the cell surface could alter physically how receptors are organized,» he said.

The group was then able to sort the cells using markers expressed on the cell surface, to help pull out successfully edited cells for research, and eventually for therapeutic use.

The virus seemed to trigger and enter through a balloonlike structure, or bleb, on the cell surface, which normally only forms during cell movement, division, or death.

This physical change causes adhesion receptors on the cell surface called integrins to clump together.

These effects can be seen as a general response to the primitive signal conveyed by NGF through its specific receptors on the cell surface.

WtCXCR4 was detected equally by both antibodies on the cell surface (middle panel, top row) and intracellularly (middle panel, lower row).

However, this is unlikely given that the frequency of in - frame mutations remained stable over nearly four weeks in culture, that there was no significant increase in cell death between control cultures and those treated with X4 - ZFNs, and that the most common in - frame mutant was not expressed on the cell surface and thus can not maintain functionality.

About 30 percent of medications on the market activate G - protein coupled receptors on cell surfaces and trigger chemical signals inside cells to yield their therapeutic effects.

The team chose integrin receptors that control a variety of functions on the cell surface as a target for their peptides.

The mRNAs are delivered to the body and direct cells to produce and express both antigenic proteins on the cell surface, much like a native infection would do but without the ability to cause disease or spread.

Clone 1022 cells ezpress human CD4 protein on the cell surface and can be infected by most isolates of HIV.

The mRNA directs cells to produce and express the proteins on the cell surface, much like a native infections would do, but without the ability to cause disease.

These chains are present on the cell surface and are crucial for many biological processes, including cell adhesion and signal transduction.

They receive signals from outside the cell via partner receptors on the cell surface, and G - proteins help deliver those signals to their proper destinations within the cell.

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

The neurotransmitter molecules act on the post-synaptic cell by binding to specific receptors on the cell surface (purple).

The Wnt proteins bind to receptors on the cell surface.