Sentences with phrase «cd8 cell composition»

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

The researchers then measured cell composition and electrical activity again and found that the cells dramatically changed when they were in contact with neurons from different regions.

They began by characterizing the cell composition, protein expression, metabolism, and electrical activity of neurons from each region in vitro.

We investigated differences in cell composition between blood samples collected pre - and post-mortem.

This ensures that sister cultures from the same subjects are similar in cell composition and differentiation state, and it avoids the influence of experimental conditions on the differentiation process (1).

Coincident with this, altered immune cell composition aberrant immune localization were detected.

A. L. Lentine, G.N. Nielson, M. Okandan, J.L. Cruz - Campa, A. Tauke - Pedretti, Voltage Matching and Optimal Cell Compositions for Microsystem - Enabled Photovoltaic Modules; IEEE Journal Of Photovoltaics, 4, 1593 (2014).

Not exact matches

The favorable composition of flora were associated with a «higher activation status» of their killer T cells within the tumor compared to those who had an abundance of Bacteroidales.

Cellular cosmologies are life compositions in that a single cell is likened to a celestial universe, only smaller.

Figuring out the quanti.tative atomic composition of a given object, whether it be a hunk of rock or a bundle of cells, is relatively straightforward.

Animals consist of limbs and tissues that are put together in a certain way, and the same goes for the limbs and tissues themselves; they — we should say their cells — have varying compositions.

It is formed from the same cells that form the organs of the baby making its genetic composition and that of the baby similar.

Its particular composition «nutrients with optimal bioavailability, hormonal and enzymatic components, anti-infective, trophic and growth factors, prebiotics and probiotics, biologically active molecules and cells» makes HM uniquely suited not only for term but also for preterm infants.

The composition of your blood also changes, creating a higher ratio of plasma to red blood cells than in non-pregnant women.

Active composition: Cyclopentasiloxane, Water (Aqua), Dipropylene Glycol, Propylene Glycol, Glycerin, Dimethicone, Dimethicone / PEG -10 / 15 Crosspolymer, Dimethicone Crosspolymer, PEG - 12 Dimethicone Crosspolymer, Butylene Glycol, Phenoxyethanol, Panthenyl Triacetate, Acetyl Tyrosine, Phospholipids, Ethyl Linoleate, Sodium Phosphate, Dimethicone / Vinyl Dimethicone Crosspolymer, Fragrance (Parfum), Hydrolyzed Sericin, Magnesium Sulfate, Proline, Oleyl Alcohol, Polysorbate 20, Retinol, Buddleja Davidii Meristem Cell Culture, Menthyl Ethylamido Oxalate, Angelica Polymorpha Sinensis Root Extract, Hydrolyzed Vegetable Protein, Adenosine Triphosphate, Dimethiconol, Dipropylene Glycol, 1,2 - Hexanediol, Pentylene Glycol, PEG - 35 Castor Oil, PEG - 12 Glyceryl Laurate, Lactobacillus / Panax Ginseng Root Extract Ferment Filtrate, Tocopherol, Sodium Citrate, Disodium Acetyl Glucosamine Phosphate, Caprylyl Glycol, Beta - Glucan, Dipeptide Diaminobutyroyl Benzylamide Diacetate, BHT, Sodium Chloride, Potassium Sorbate, Hexylene Glycol, Xanthan Gum, PVP, Disodium EDTA, BHA, Limonene, Linalool, Citral, Citronellol.

The scientists discovered that the two sides of the cell differ in the composition of messenger RNA, or mRNA: About 30 percent of the genes expressed in the intestines produced mRNAs that appeared either on one side of the cell or on the other.

There were clear differences in the composition of immune cells in the wounds and the immune cells present produced higher levels of TGFß at earlier time points.

The more the composition was enriched with copper, the higher the concentration was of other point defects considered to be detrimental to the performance of solar cells.

However, lipid compositions vary between cells and cellular structures within the same organism, so diet isn't the only factor determining which lipids are manufactured.

There are details of the structure of the living cell, essential features in the composition of metals, cotton, silk, rubber, paint, bone, nerve, and a thousand other things which are hidden even from the microscope, and must always remain so hidden because the failure does not lie with the skill of the optician but with the incapacity of light itself.

«Hormone - producing cells are particularly susceptible to perturbed fatty acid metabolism and often have difficulties in regulating their membrane lipid composition.

The shape and chemical composition of these granules is identical to organelles found in cells called melanosomes; these being responsible for creating and storing the pigment melanin.

«Cancer therapies that attack the lipid composition of the cell membrane would be an entirely new class of anticancer drugs,» says co-senior study author Paul Beales, of the University of Leeds in the UK.

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

By carefully controlling the composition of the droplets and the strength of the magnetic field, the forces applied by the droplet can be controlled, and the response of the surrounding tissue reveals its mechanical characteristics as well as the cues that cells are exposed to as the tissue grows.

Different clonal memory cell populations had different B cell or macrophage helper compositions that matched effector cell populations generated much earlier in the response.

Roswell Park Cancer Institute (RPCI) researchers used deep T - cell receptor (TCR) sequencing to evaluate the clonal composition of TILs and identify novel prognostic biomarkers in ovarian cancer.

The ability of tumor - infiltrating lymphocytes (TILs) such as T cells to produce multitudes of clones that overwhelm and effectively control cancer cells has been demonstrated, but the significance of the composition of T - cell repertories is unknown.

Moriguchi also presented a July 2011 patent application for «Methods and Compositions for Reprogramming Cells,» that names himself and Chung as the inventors and designates the assignee as «The General Hospital Corporation, Boston, MA,» the MGH legal entity.

It shows that indeed you can make cells that talk to each other and they can change the composition of the material over time,» Lu says.

The researchers also demonstrated that the cells can coordinate with each other to control the composition of the biofilm.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

To find out why, computational biologists came up with a computer model to predict how microbial metabolism and cellular composition change as cell size varies, using details about how much space a bacterium needs for its components — DNA, proteins, and the molecular factories called ribosomes — to function.

The researchers analysed the genetic composition of myocardial cells using state - of - the - art gene sequencing technology.

Previous work by the researchers developed plasma - activated cell culture medium as a form of chemotherapy, but selected Ringer's solution in the present work because of its simpler composition and likelihood of forming less complex reaction products.

For the well - being of the cell, it has to adjust the composition of its membrane proteins and lipids constantly.

To optimize the communication, the cell needs to adjust the composition of its membrane at any time.

The composition of these membrane molecules changes dramatically with cell differentiation and the onset of cancer.

«It is striking that these changes, found in many human cancers, can be induced in normal mammary epithelial cells simply by varying the stiffness or composition of the matrix surrounding them.»

The link between endocytosis and generation of cortical actin waves may provide deeper insight into how cells maintain the composition and dynamics of the plasma membrane.

By varying properties such as charge, composition, and attached surface molecules, researchers can design nanoparticles to deliver medicine to specific body regions and cell types — and even to carry medicine into cells.

In addition to quantitative mineralogy, Rietveld refinements also provide unit - cell parameters for the major phases, which can be used to infer the chemical compositions of individual minerals and, by difference, the composition of the amorphous component.

«We came closer to a basic screening of cells» GLUT composition — one that both detects cancer and distinguishes type,» Tanasova says; adding that while the concept is elegant, developing the technology is not easy.

The structure and composition of the erionite from both regions is practically identical, and samples from each place cause mesothelioma - associated changes and inflammation in cell culture and mouse lungs.

The cell walls of the FHB - resistant variety had a particular composition of lignin — a structural component which plays a crucial role in cell wall reinforcement — and showed unique compositions of other structural components including pectin and hemicellulose.

Once manufactured, whereby thin layers were applied with precise composition by atomic layer deposition (ALD), the researchers compared the stability of these cells with identical cells without this layer.

Almost all cells in the human body have identical DNA sequences, yet there are 200 - plus cell types with different sizes, shapes, and chemical compositions.

The researchers observed a periodic variation in the cell's lipid composition, similar to what they noticed in human subjects.

The researchers were also able to control the relative composition of different hormonal cell types simply by exposing human pluripotent stem cells to different ratios of two proteins: fibroblast growth factor 8 and bone morphogenetic protein 2.

Learning how to control the composition of secondary cell walls is an area of intense interest among advanced biofuel researchers because the structures make up the bulk of the plant matter that is broken down into biofuels.