Sentences with phrase «cns diseases»

The projects will begin during the fall and are intended to improve our understanding of the molecular mechanisms surrounding tumor disease, heart failure, diabetes, inflammatory diseases, asthma and COPD, CNS diseases and stem cell biology.

Showed that blood proteins not only mark BBB disruption, but also cause both pro-inflammatory and neurodegenerative effects in CNS diseases.

«We've seen microglia dysfunction in other diseases like schizophrenia, and so now this allows us to connect lupus to other CNS diseases,» says Bialas.

The findings support the idea of eye examinations as potential screening tools for CNS diseases.

Functional changes of the retina were found in three mouse models of human CNS diseases whose phenotype, age of onset and pathological mechanism clearly differ from each other.

These methods were used to test different attributes of vision in three distinct genetically engineered mouse models of human CNS diseases.

PTC and Roche are old friends and signed an agreement in September 2009 to develop orally bioavailable small molecules using PTC's GEMS technology, focusing initially on four CNS disease targets.

These include age related macular degeneration and probably accelerated atherosclerosis and also probably CNS disease and dementia.

Not exact matches

About Alkermes plc Alkermes plc is a fully integrated, global biopharmaceutical company developing innovative medicines for the treatment of central nervous system (CNS) diseases.

Alkermes plc is a fully integrated, global biopharmaceutical company developing innovative medicines for the treatment of central nervous system (CNS) diseases.

The disease is characterized by the accumulation of very long chain fatty acids (VLCFA) leading to a neurodegenerative disorder that is chronically debilitating and life - threatening, where the most affected tissues are the myelin in the central nervous system (CNS) and the adrenal cortex.

It is a differentiated PPAR gamma agonist with a superior profile for CNS related diseases with excellent in - vivo efficacy, a comprehensive development plan and early involvement from key opinion leaders.

CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease.

With the potential to affect such a diverse array of neurological ailments, many of which have no known therapy, the hope is that an improved understanding of immune - CNS interactions will bring to light new paradigms for preventing and treating neurological disease.

The immune system's reach within the CNS is extensive, probably contributing to the initiation and pathogenesis of neurodegenerative diseases, neurodevelopmental disorders such as autism, and mental health disorders such as schizophrenia.

We now know that the immune system is very likely a key player in many neurological diseases and, surprisingly, that immune - CNS interactions may not all be bad.

Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.

Recent advances have raised expectations that diseases of the CNS may be improved by the use of stem cell therapies.

«CNS lupus is not just an undefined cluster of neuropsychiatric symptoms, it's a real disease of the brain — and it's something that we can potentially treat.»

Now, new research from Boston Children's Hospital has shed light on the mystery and points to a potential new drug for protecting the brain from the neuropsychiatric effects of lupus and other central nervous system (CNS) diseases.

Our results suggest that a pandemic H5N1 pathogen, or other neurotropic influenza virus, could initiate CNS disorders of protein aggregation including Parkinson's and Alzheimer's diseases.

As an experimental approach, I believe in the need for the combined molecular, behavioural and neuropathological / neuroanatomical study of animal models of disease and CNS dysfunction.

Exclusion criteria were: lymphoma outside the CNS, HIV positivity, inadequate bone marrow function, liver disease, creatinine clearance less than 60 mL / min, organ transplantation, prior radiotherapy to the brain, previous malignancy unless disease free for at least five years, pregnancy or lactation.

I - Stem, the Institute for Stem cell Therapy and Exploration of Monogenic Diseases, has signed an agreement with Swissbased healthcare company Roche to use I - Stem's technologies in discovering novel therapies to treat devastating central nervous system (CNS) diseases such as Alzheimer's, schizophrenia, depression and anxiety.

We aim to unravel the molecular mechanisms of the central nervous system's (CNS) response to neurovascular changes, with the ultimate goal to develop novel therapeutic strategies for neurological diseases.

Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature

[34] Despite high systemic RRs, many patients exhibit disease progression with CNS metastasis within 1 year of starting crizotinib therapy.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

The study, led by researchers at the University of Cambridge, is a step towards developing personalised treatments based on a patient's own skin cells for diseases of the central nervous system (CNS).

Cell biology chair Gary Bassell was interested in the disease, because it's a triplet repeat disorder, similar to fragile X syndrome, yet the CNS mechanisms and symptoms are very different.

In a commentary accompanying the article, professor Vivian Teichberg, a neurobiologist at the Weizmann Institute of Science, described this technology as a breakthrough that can influence the outcome of many CNS related diseases.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very aggressive type of cancer with multiple manifestations including skin lesions, abnormal cell counts and central nervous system (CNS) disease involvement.

Press Release: Innovate UK awards grant to CN Bio to use Organs - on - Chips to evaluate the use of drugs to treat fatty liver disease

They concentrate on a specific Therapeutic Area (i.e. Oncology, Cardiology, CNS, Pulmonary, Hematology, Surgery, Women's Health Care, etc) and disease state.

HOUSTON (CN)-- Injected with 600 million stem cells grown from his own stomach fat, an elderly man said the injections stopped his Parkinson's disease tremors and he's now teeing up his own golf balls and competing in golf tournaments.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criteria

A failure of normal astrocyte generation by CNS precursor cells has been discovered to be a consequence of the mutations that cause Vanishing White Matter leukodystrophy [7], and dysfunction of astrocytes has also been suggested to be of importance in models of amyotrophic lateral sclerosis [8], forebrain ischemic injury [9], epileptic seizures [10], Huntington's disease [11], tuberous sclerosis [12] and Rett syndrome [13].

Host: Dr. Yu Tian Wang Speaker: Dr. Stephen Ferguson, Univ. of Ottawa Title: Role of G protein - coupled receptor signaling in diseases of the CNS

We and others have found that NMNAT2 levels are significantly reduced in CNS tissues from patients with Alzheimer's disease, tauopathies, or Parkinson's disease.

AAV gene therapy vectors are emerging as the gene transfer vehicle with high potential for use in the CNS as they transduce post mitotic cells that mediate the sustained, long term gene expression required in chronic progressive diseases.

Abbreviations: ACVR2A, activin A receptor type IIA; BMP, bone morphogenetic protein; BMPR, BMP receptor, type II; CNS, Central nervous system; DA, dopaminergic; DMEM / F12, Dulbecco's modified Eagle's medium nutrient mixture F - 12; E, embryonic day; GDF, growth differentiation factor; GO, gene ontology; KEGG, Kyoto encylopedia of genes and genomes; MAPK, Mitogen - activated protein kinase; mDA, midbrain dopaminergic; PD, Parkinson's disease; RIPA, radioimmunoprecipitation assay; SN, Substantia nigra; TGF - β, transforming growth factor - β; TH, tyrosine hydroxylase; VM, ventral midbrain / mesencephalon; Zeb2, Zinc finger E-box-binding homoeobox 2

Project Title: «A nanomedicine approach for theranostic of central nervous system (CNS) diseases»

Module 2 — GI Part 2 — The Spectrum of Gluten Related Disorders with special guest faculty, Tom O'Bryan, DC, CCN, DABCN Module 3 — An Integrativen and Functional Nutrition Approach to Brain Related Disorders with special guest faculty, Jay Lombard, DO Module 4 — CardioMetabolic Disease, Inflammation and Insulin Dysregulation with special guest faculty, Cynthia Geyer, MD Module 5 — An Integrative and Functional Nutrition Approach to Obesity and Weight Management with special guest faculty, Mark Pettus, MD Module 6 — Detoxification: The Role of Toxicity in Chronic Disease with special guest faculty, Deanna Minich, PhD, FACN, CNS, IFMCP (NOTE: CEUs not offered for this module) Module 7 — An Integrative and Functional Nutrition Approach to Cancer Therapies with special guest faculty, Dr Lisa Alschuler, ND, FABNO Module 8 — Adrenal, Thyroid and Hormonal Dysfunction with special guest faculty Joel Evans, MD (NOTE: CEUs not offered for this module) Module 9 — Energy and Pain Disorders / Mitochondropathy with special guest faculty Robin Foroutan, MS, RDN, HHC

There is emerging evidence for acne, PCOS, exercise performance, wound healing, longevity, cancer, CNS Oxygen Toxicity, autism, Angelman's Syndrome, ALS, MS, Neuropathies, Alzheimer's disease, brain injury, neurodegeneration, anxiety, depression, bipolar and schizoaffective disorder.

A number of CNS pathologies, inclusive of neurodegenerative diseases incur increased BBB permeability and dysfunction, and this loss of a protective barrier allows relatively free entry of circulating blood macromolecules in the CNS.

Recently, adipokines have been invoked as mediators of an ongoing crosstalk between adipose tissue and the CNS that on occasion, following an unknown trigger, can result in neuroinflammation and neurodegenerative diseases (44).

Canine cyclic neutropenia (CN), also known as gray collie syndrome (GCS), is an autosomal recessive disease.

In the extreme stages of the disease, the virus affects the other bodily systems, particularly the central nervous system (CNS); the dog may begin having seizures, fits and paralysis.

The immune system, specifically microglia, the primary immune cells of the central nervous system (CNS), has been implicated in ALS disease progression.

It is used in the management and treatment of immune mediated disease such as immune mediated hemolytic anemia, or thombocytopenia: many CNS disorders: some neoplasia: dermatologic diseases: allergic reactions such as asthma, hives, and itching: inflammatory orthopedic diseases: endocrine disorders including Addison's: respiratory disease with an inflammatory component, inflammatory bowel diseases and many other conditions.