Sentences with phrase «cns effects»

Ghosal, S., et al. «Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera,» Phytother Res, 3 (5): 201 - 6, 1989.

I think what you are describing — CNS effects with excess folate pertain to the situation in which a person is B12 deficient and excess folate masks B12 deficiency... but B12 is needed for CNS function and folate can not mask that effect.

Not exact matches

The CNS related effects lead to two main phenotypes: adrenomyeloneuropathy, (AMN) characterized by progressive motor dysfunction, and cerebral ALD (cALD), characterized by severe neuroinflammation leading to early death.

So the strong binding to its intended receptors, its short half life, its specificity to receptors in the CNS, and its lipophilicity which makes it difficult to cross the placenta all make Fentanyl a good choice for laboring women and unlikely to have much effect on the baby.

Fentanyl is actually a better agonist (bind more efficiently) to the opioid receptors in the CNS and has less nonspecific binding so it actually causes less general side effects.

Disease - driving mechanisms vary and include, among others, the pruning of neuronal synapses, effects on CNS development in utero, and inflammation.

Now, new research from Boston Children's Hospital has shed light on the mystery and points to a potential new drug for protecting the brain from the neuropsychiatric effects of lupus and other central nervous system (CNS) diseases.

Showed that blood proteins not only mark BBB disruption, but also cause both pro-inflammatory and neurodegenerative effects in CNS diseases.

Taken together, our results demonstrate that the intraneuronal development of AD - like amyloid pathology includes a mixture of molecular species (Aβ, APP and CTFs) of which a considerable component is Aβ; and that the early presence of these species within neurons has deleterious effects in the CNS, even before the development of full - blown AD - like pathology.

In order to better understand the liabilities associated with reducing normal htt in adult mice, we evaluated the effects of a robust knock down of WT htt both in CNS and periphery in a conditional htt knock - down (KD) model induced by doxycycline.

In addition, J147 has good medicinal chemical and pharmacological properties for a CNS drug, has few off - target effects and is orally active [7].

While previous studies had demonstrated a synergistic effect of BMP and LIF on the astrocytic differentiation of human neural stem cells [15], it remains unclear whether BMP and LIF induce distinct types of astrocytes and if so, what the functional properties of these astrocytes may be with respect to repairing CNS injuries.

We have developed several chemical series of potent, selective, orally bioavailable and CNS - penetrant catalytic - site inhibitors of Class IIa HDACs [2,3], to probe whether HDAC4 inhibition can replicate the beneficial effects of HDAC4 reduction in HD models.

Besides caffeine's boosting effect on CNS activity, there is also the combined impact of caffeine's metabolites theobromine, which improves nutrient and oxygen flow to your brain, theophylline which relaxes the muscles and improves heart rate efficiency and paraxanthine, which improves lipolysis, the process where fats are broken down to be used as an energy source.

The anorexic effect of dietary protein, which may be due in part to increased CNS leptin sensitivity, is apparently stronger than any orexigenic effect of increased ghrelin concentrations accompanying weight loss with a high - protein diet.

Taken together, these results suggest that increased protein intake enhances the satiating effect of circulating leptin in the central nervous system (CNS).

(12, 13) Finally, pathogenic gut microbes can also initiate a proinflammatory state that increases intestinal permeability, resulting in the leakage of neuroactive metabolites from the gut into the CNS, where they have adverse effects on cognition.

Such effects may occur through a process of «neurohormesis» in which cellular components of the CNS respond to exogenous and endogenous toxic agents (e.g. - H2S, NO, CO, glutamate, calcium) that act as mild stressors to facilitate neuronal resistance against stronger insults.»

WARNINGS, PRECAUTIONS and CONTRAINDICATIONS: Due to serious human safety and abuse concerns, including physical or psychological dependence, life - threatening respiratory depression and additive CNS depressant effects, read the full prescribing information before using this drug, including the complete Boxed Warning.

Methods; These Neurotransmitters are visualized through the effects they have on the Human Central Nervous System (CNS).