Sentences with phrase «cns tumors»

Brain and other CNS tumors are the 11th most common cancer in the UK, accounting for 3 % of all new cases (2).

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors -LRB-

A phase I trial of ramucirumab, a human monoclonal antibody against the vascular endothelial growth factor - 2 (VEGFR - 2) receptor, in children with refractory solid tumors, including CNS tumors (NCT02564198).

It is presently possible to differentiate about 100 types of CNS tumors based on tissue characteristics.

«We hope that our new molecular classification method will help improve diagnostic accuracy in CNS tumors and, thus, also improve the chances for successful treatment,» said von Deimling.

«We have developed computer - based algorithms that reliably differentiate 82 types of CNS tumors based on their methylation patterns,» said Professor David Capper, who is one of the four first authors of the study.

In order to enhance the diagnosis of CNS tumors, a team led by Professor Stefan Pfister, KiTZ director and department head of «Pediatric Neurooncology» at the DKFZ, in collaboration with colleagues from the Neuropathology Department at Heidelberg University Hospital led by Professor Andreas von Deimling, have developed a new computer - based method.

Physicians will now be able to categorize CNS tumors more precisely into specific risk groups and make therapy decisions on this basis.

Not exact matches

These drugs are also frequently used to manage central nervous system (CNS) disorders associated with a pathologically permeable BBB, such as with brain tumors and multiple sclerosis.

Little is known about how CNS - PNETs develop, although these tumors are more aggressive than other PNETs and have an overall survival rate of only about 20 percent.

To be able to treat cancer of the central nervous system (CNS) successfully, it is important to have very precise knowledge about the molecular characteristics of the tumors in order to «give them the right name.»

Chemotherapy Alone as Initial Treatment for Primary CNS Lymphoma in Patients Older Than 60 Years: A Multicenter Phase II Study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group

One such example is a rare, aggressive childhood brain tumor called primitive neuroectodermal tumor of the central nervous system (CNS - PNET).

Led by St. Jude and the German Cancer Research Center, an international research team used molecular techniques to compare hundreds of tumors classified as CNS - PNET to other known brain tumors.

About 22,000 new cases of brain and central nervous system (CNS) tumors are diagnosed each year in the United States, and 3,000 of those are in children.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

And, the multidisciplinary and multi-institutional University of Michigan CNS Precision Medicine conference is held monthly in order to optimize the diagnosis and treatment of children with brain tumors through a precision medicine approach.

Intravenously - delivered NSCs preferentially migrate to primary and metastatic tumor sites within and outside the CNS.

The projects will begin during the fall and are intended to improve our understanding of the molecular mechanisms surrounding tumor disease, heart failure, diabetes, inflammatory diseases, asthma and COPD, CNS diseases and stem cell biology.

In addition to improving distribution of antibodies to the CNS and within malignant solid tumors, this strategy could expand the number of targets to which antibodies can be directed.

Consequently, poorly vascularized solid tumors and CNS metastases can not be effectively treated by intravenously - injected antibodies.

Central nervous system (CNS) tumors pose a particular challenge for antibody therapeutics, because the blood - brain barrier (BBB) prevents intravenously - injected antibodies from reaching CNS metastases.

When a pet has a brain tumor there will be increased pressure within the central nervous system (CNS).

If your dog has a seizures caused by a brain tumor or infection / inflammation in the central nervous system (CNS), we might see neurologic signs like uneven pupils.