Sentences with phrase «creb phosphorylation»
We previously demonstrated that J147 up - regulates the BDNF pathway in huAPP / PS1 mice following seven months of treatment, and here we show that even when administered at a stage when pathology is advanced, J147 can significantly increase two factors critical for memory formation: CREB phosphorylation and BDNF expression (Figure 3H and 3C, respectively).
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Thus the phosphorylation of CREB by J147 could increase the levels of BDNF, which consequently may increase BDNF responsive proteins.
We also CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca 2 + / calmodulin - dependent protein kinases on the Serine 133