Sentences with phrase «crispring typical mouse»

The study compared intestinal wound healing in two groups of mice: 1) typical mice (wild type) found in nature and 2) mice genetically deficient in the healing factor IL - 10, specifically in macrophages, which impairs their ability to have normal wound repair.

The enhanced mice masterfully memorized new objects, swiftly learned to link certain sounds or situations to an unpleasant foot shock, and displayed un-usually savvy maze navigation — signs of mental acuity that surpassed skills exhibited by either typical mice or mice transplanted with glial progenitor cells from their own species.

When the pups get older, they will learn to paddle through water mazes or bury black marbles in their bedding, giving researchers insight into how their memory and behavior compare with that of typical mice.

Unlike typical mice, these mice do not show interest in interacting with an unfamiliar mouse.

This learning persisted for 3 days, during which time typical mice did not learn at all, despite being treated in exactly the same way.

But CRISPRing typical mouse models, including creating Cre - dependent conditional alleles, has remained a challenge.

The cells displayed the typical mouse ES cell morphology and self - renewed in vitro for a long period of time (more than 30 passages).

It took some time to get used to moving around the screen, but once I got the hang of it, it felt as natural as a typical mouse.

The game recommends controllers as the preferred input method over a typical mouse and keyboard combination.

It features three different gaming modes including a mouse mode that allows for the assignment of typical mouse navigation to the action buttons and analog joystick.

DPI is different from the typical mouse sensitivity setting.

Not exact matches

In a typical interaction lasting several minutes, the larger mouse chases the smaller mouse, displaying aggressive behavior and emitting warning calls.

Despite the presumed virulence of the strain — experiments with mouse lungs showed it produces 1000 times more bacteria in infected cells than do standard varieties — Valway says the number of TB cases that developed were kept in line with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»

On measuring the males, they found that the testicles of the yogurt consumers were about 5 percent heavier than those of mice fed typical diets alone and around 15 percent heavier than those of junk - eating males.

Typical pain treatment research begins with an animal model — one that uses only male mice.

There's been a growing realization among diabetes researchers that human islet development differs significantly from islet development in typical laboratory animals like mice.»

The difference might be subtle: Researchers have identified one strain of mice that seals up ear holes in weeks, whereas typical strains never do.

Scientists gave the mice a typical daily dose of paracetamol — over a period of either 24 hours or seven days.

The researchers found that in mice, a single injection of 30 millionths of a gram of these mRNAs — a small fraction of the dose used for a typical vaccine — induced a rapid immune response, which protected mice from intravenous exposure to a separate Zika strain two weeks later.

When Bading halved the amount of the enzyme in the brains of young mice, their performance deteriorated to that of typical elderly mice (Nature Neuroscience, DOI: 10.1038 / nn.3151).

We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ - free mice fed low - fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet.

Later, he found that the inhibition of this signaling route also protected Alzheimer's - model mice from behavioral impairments and pathological phenomena typical to the disease.

According to Yang and Silverman, a typical behavioral test aims for 20 mice per group in order to achieve sufficient statistical power.

In addition, the sperm heads of this mouse «are huge,» suggesting that they pack much more DNA than typical rodent sperm does, Gallardo notes.

Although genetically modified mice have been used widely to model neurodegenerative diseases, they lack the typical neurodegeneration or overt neuronal loss seen in human brains, says corresponding author Xiao - Jiang Li, MD, PhD, distinguished professor of human genetics at Emory University School of Medicine.

In the study, the impact of dieting was simulated by reducing the mice's caloric intake by 20 to 30 percent — roughly equivalent to the caloric reduction of a typical human dieter.

Studies in typical model animals — mice — are rarely illuminating, because the rodents often still behave normally when researchers manipulate genes that should cause these disorders.

In 2012, a group from the RIKEN Center for Life Science Technologies, in collaboration with SISSA, an Italian University, discovered a new class of mouse lncRNAs, which are called «antisense» because their can pair with typical protein - coding mRNAs and enhance their translation.

A third study showed that similar injections into normal mice caused some of the neurodegeneration typical of Parkinson's disease and the mice became less agile.

The maximum life span of a typical lab mouse is 39 months, corresponding to 110 years in humans.

Scientists have found a group of human sequences — unrelated to those in mice — which are capable of producing SINEUPs, which can pair with typical protein - coding mRNAs and enhance their translation.

This is a typical way for mice to display their social dominance, Feng says.

Until now, the human gut has been hard to study because it's so different from those in typical model organisms like mice, so these tiny tummies open up a world of possibility.

Earlier this year, Stanford University's Justin Sonnenburg found that mice fed a typical Western diet (high in fat and carbohydrates and low in fiber) transferred a lower diversity of beneficial microbial species to future generations.

«When implanted into the tibia or onto the skull of mice, moreover, we discovered that cells expressing miR - 940 can induce the kind of osteoblastic lesions that are typical of prostate cancer.»

What's more, the mice developed symptoms typical of rheumatoid arthritis in humans: Their joints became inflamed and were filled with immune system chemical messengers, such as TNF - α, which make the immune system turn on the body.

In a set of papers out today in the journals Nature Genetics and Nature Communications, researchers at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms that promote metastasis in the mouse model and also implicated the typical Western high - fat diet as a key environmental factor driving metastasis.

In these conditions, mice can exhibit a more natural set of exploratory behaviors than in the more typical confining cage.

Importantly, intraperitoneal inoculation of pancreatic homogenates containing IAPP aggregates into transgenic mice expressing human IAPP dramatically accelerates IAPP amyloid deposition, which was accompanied by clinical abnormalities typical of T2D, including hyperglycemia, impaired glucose tolerance, and a substantial reduction on β cell number and mass.

To study the ability of IAPP aggregates to induce IAPP misfolding and other pathologic alterations typical of T2D in vivo, we performed experiments using Tg - hIAPP mice.

The SAMP8 mouse is not a traditional model for Alzheimer's disease, and oligonucleotide administration is not a typical treatment.

The results of a typical experiment are shown in Figure 3 and demonstrate that even though spleen cells from CD4 KO mice could adoptively transfer corneal allograft rejection, they did not display conventional CTL activity against either BALB / c corneal epithelial or endothelial cells.

In previous studies, Campbell's team had found that knockout mice lacking α - sarcoglycan had no heart muscle damage, even though their skeletal muscles showed the deterioration typical of MD..

Suvorov wanted to test in mice whether pollutants might cause or intensify behaviors typical of autism or ADHD.

Given that there are millions of cells in a typical skin biopsy (researchers used skin from either the end of the tail or from the ear of the mouse), that translates into thousands of stem cells, each one capable of developing into any cell type of the body.

Now, scientists have shown that supplementing healthy mice with NMN — found in foods such as broccoli, avocado, cabbage, and cucumber — can compensate for this loss of energy production, reducing typical signs of aging such as gradual weight gain, loss of insulin sensitivity and declines in physical activity.

Mice infected with B31 - A3 and ospC7 / ospC +4 strains mounted typical and similar immune responses to OspC, P39 [used as a marker for infection in animals (22)-RSB-, and additional borrelial proteins (Fig. 4).

Comparison of Typical and Atypical Antipsychotics on PCP - Induced Hyperactivity in Mice B.J. CALDARONE, M. NILGES, M.L. MANZANO, S.A. MALEKIANI, A.C. FEDOLAK, P. MCGINIGLE, and T. HANANIA... Abstracts / Posters

Here, we hypothesized that cyanidin 3 - glucoside (C3G), a typical anthocyanin reported to possess potent anti-inflammatory properties, would ameliorate obesity - associated inflammation and metabolic disorders, such as insulin resistance and hepatic steatosis in mouse models of diabesity.

Mice stressed by fox odor, temporary restraints, and nighttime lighting, during their first trimester were found to be vaginally colonized by different bugs than those leading a more typical existence.