Sentences with phrase «csc subpopulation»

We hypothesised that breast CSC numbers would be altered in hypoxia via dedifferentiation of non-CSC or by expansion of the CSC subpopulation.

Therefore, we hypothesize that hypoxia / reoxygenation cycles may provide the driving force to select for a highly metastatic breast CSC subpopulation.

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Within tumors, there exists a subpopulation called the «cancer stem cells» (CSCs).

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

The percentage of CSCs in the cycling hypoxia selected subpopulation was analyzed based on the CD44, CD24, ESA, and E-cadherin expression by three - color flow cytometry.

With the recent success of identifying selective inhibitors targeting CSCs, we believe that the newly isolated cycling hypoxia - selected subpopulation may present a new opportunity for chemical screening and discovery of compounds with selective toxicity for metastatic breast CSCs.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.

Cancer stem cells (CSCs) known as tumorigenic cells are biologically distinct from diverse subpopulations.