Sentences with phrase «ctl escape»

One of the best pieces of evidence that CTLs exert selective pressure on HIV - 1 is the existence of CTL escape mutations.

During a post-doc at Massachusetts General Hospital, Boston, under the mentorship of Bruce Walker, he studied mother - to - child transmission of HIV at Boston Children's Hospital and showed that CTL escape mutants can be transmitted stably and significantly impact disease progression in the recipient (Goulder et al, Nature, 2001).

Not exact matches

Consequently both effector cells can operate in tandem, with NK cells providing a first line defense killing target cells that escape CTL recognition or show inadequate expression of self - MHC 142.

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).