Sentences with phrase «ctl responses»

Such virus variants selectively suppress LCMV - specific CTL responses and cause persistent infections in immunocompetent mice.

Our results show that LCMV variants that emerge during infection in vivo play a crucial role in the suppression of virus - specific CTL responses and in the maintenance of virus persistence.

7031.1 contains residues from all 3 regions linked by proline residues.Regions may be involved in CTL responses.

The suppression of LCMV - specific CTL responses by carrier spleen cells is not mediated by a suppressor cell, but is due to the presence of genetic variants of LCMV in spleens of carrier mice.

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.

The suppression was specific for the CTL response and LCMV - specific antibody responses were not affected.

In striking contrast, wild - type LCMV Armstrong, from which these variants were generated, induces a potent CTL response in immunocompetent mice and the LCMV infection is rapidly cleared.

Using adoptive transfer experiments we found that spleen cells from persistently infected (carrier) mice actively suppressed the expected LCMV - specific CTL response of spleen cells from normal adult mice.

There is good evidence that the CTL response contributes to the control of HIV - 1 infection in vivo [7 — 11].

Not exact matches

Allospecific CTL and DTH responses have been associated with the immune rejection of various categories of allografts.

We studied the mechanism of lymphocytic choriomeningitis virus (LCMV) persistence and the suppression of cytotoxic T lymphocyte (CTL) responses in BALB / c WEHI mice infected at birth with LCMV Armstrong strain.

Many studies in tumor models have forcibly provided 4 - 1BB signals, injecting either agonist antibodies to 4 - 1BB, or transfecting 4 - 1BBL into the tumor cells, also highlighting the stimulatory capability of 4 - 1BB in driving suppression of tumor growth largely through augmenting CTL and NK responses.

While ZVex primes the immune system by triggering the generation of CTLs, GLAAS, by activation of CD4 cells, boosts the immune response by expanding and enhancing the function of CTLS and other anti-tumor mechaniCTLs, GLAAS, by activation of CD4 cells, boosts the immune response by expanding and enhancing the function of CTLS and other anti-tumor mechaniCTLS and other anti-tumor mechanisms.

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.

Together, they are designed to induce a synergistic anti-tumor cytotoxic T lymphocyte (CTL) response targeting NY - ESO -1-expressing tumors.

We believe DCs are the most important immune cells to target because they initiate the specific immune response that generates CTLs to kill the tumor.

CTL, all he says in that comment is he is «working on a few responses.»

It remains uncertain what role Atlantic SST anomalies play in generating the low - frequency Pacific wind response and the simulated North American precipitation anomalies in CTL.

In response to the ongoing interest and, specifically, the need for our colleagues to associate with like - minded professionals, we have created the CTL Associate designation with a wealth of benefits and opportunities.