Sentences with phrase «cxcl12 in subsets of patients»

Zytiga's approval was based on trials showing a 38 % reduction in the risk of death in this subset of patients, an improvement that's clearly influencing doctor's use of the drug.

Cancer immunotherapy can produce durable clinical responses, but only in a subset of patients.

In addition to anti-tumor responses, immune checkpoint inhibitors have also been associated with long - term remission in a subset of patients, Gu said.

After a median follow - up of 22 months, the team found that the drugs were safe and shrank tumors in a subset of patients, with an overall response rate of 27 percent, which included complete responses in two patients and partial responses in four patients.

This, in turn, amplifies the effectiveness of fulvestrant, a drug commonly used in this subset of patients.

The study was not powered to detect this improvement, but Kelbaek said he and his team would now look carefully for possible «hypothesis - generating» findings in subsets of patients — both those who might have benefitted from the deferred - treatment strategy and, equally important, those in whom this strategy might have worsened their condition.

«We found that intensive doses of statins carry the potential for clearing up the lipid debris that can lead to vision impairment in a subset of patients with macular degeneration,» said Joan W. Miller, M.D., the Henry Willard Williams Professor and Chair of Ophthalmology at Harvard Medical School and Chief of Ophthalmology at Massachusetts Eye and Ear and Massachusetts General Hospital.

Professor Dive added: «We propose that this drug will be most useful in this subset of patients who have elevated MCT1 levels and need more effective treatments.

While the alert system did not improve outcomes, in a subset of patients it did increase interventions, including more renal consultations and dialysis.

They can also induce responses against normal tissue antigens, leading the immune system to attack normal tissues and cause toxicity in a subset of patients.

Targeted drugs and combination therapies can drive cancer into remission, as they achieve optimal results in subsets of patients.

It is the first treatment targeting the underlying cause of CF in a subset of patients with a specific mutation.

MYH7 mutations were predominantly found in Ebstein anomaly associated with LVNC and may warrant genetic testing and family evaluation in this subset of patients.

In addition, HER2 is expressed in many normal tissues, giving systemic HER2 - targeted antibody therapy the potential to cause toxicity in a subset of patients, including cardiac myopathy, congestive heart failure, and pulmonary toxicity [14], [15].

The cytokines interleukin - 2 (IL - 2) and interferon - alpha cause kidney cancers to shrink in approximately 10 % -20 % of patients, and provide durable remissions in a subset of these patients.

Would you think it is plausible that at least in a subset of patients the psychological symptoms develop as an outgrowth of the inability to properly store fat?

A growing number of studies also suggest that HHV - 6 may play a role in a subset of patients with chronic conditions.

Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients.

The nomogram also performed well in subsets of patients at the extremes of weight and renal function (Table 3).

Not exact matches

Not only does this suggest that the cause of Crohn's disease in these patients may be oxidative stress due to dysfunctional MDR1, but that for the subset of patients with this dysfunction, bile acid sequestrants may be an effective treatment.

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

If hypofractionated radiation with curative intent can reduce the treatment time for lung cancer patients by half with no greater toxicity, and with equivalent — if not better — tumor control and survival outcomes, this research could result in a change in the paradigm of how a large subset of locally advanced NSCLC patients are treated.»

The team now plan to examine the effect of levothyroxine medication on a subset of subclinical hypothyroidism patients who also have heart conditions in more detail.

This study involved a subset of patients enrolled in a clinical trial of pediatric AML called AML02.

«There has been a tremendous effort over the past several years to block EGFR as a treatment for lung cancer, but this therapy only works in a small subset of patients.

Not only does the study suggest these drugs are safe for this subset of migraine patients, it could also have implications for the nearly 10 million migraine sufferers who experience auras — a disturbance in vision, touch, speech, thinking, or strength that usually precedes a migraine headache.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients.

In a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subseIn a matched cohort of 1,706 patients in each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein each arm, the researchers still found an overall survival benefit with BCT over mastectomy in the HR positive subset but not in the HR negative subsein the HR positive subset but not in the HR negative subsein the HR negative subset.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

In a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutationIn a randomized, phase 2 multi-center clinical study, led by Manisha Shah, MD of The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), investigators tested the effectiveness of the targeted therapy drug, dabrafenib (pronounced «da bRAF e nib» and marketed as Tafinlar), given alone compared with the same drug given in combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutationin combination with trametinib (pronounced «tra ME ti nib,» marketed at MeKinist) to treat a subset of advanced papillary thyroid cancer patients with B - raf mutations.

When Dillon and colleagues used a global proteomics approach to compare all proteins in the blood from a subset of the patients, CRP emerged with the strongest association to postoperative delirium.

Currently, only a fraction of patients respond to immunotherapy, and immunotherapy only works in a subset of cancers.

A subset of these changes was much more prevalent in lung - cancer patients than cancer - free smokers.

Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting of the American Society of Hematology (ASH).

Yet research and clinical observations over the past 40 years have raised concerns that these drugs produce suicidal thoughts, suicide attempts and possibly even suicide in a small subset of depressed patients.

Therapies that prevent tumor blood vessel growth are often used in clinics to fight cancer — but they are only effective in a particular subset of patients.

The drug — named mepolizumab — can replace traditional, steroid - based treatments for a specific subset of patients, resulting in improved outcomes and reduced side effects.

In a subset of 6 patients who underwent kidney transplantation, the procedure led to a significant drop in TMAO levelIn a subset of 6 patients who underwent kidney transplantation, the procedure led to a significant drop in TMAO levelin TMAO levels.

The study enrolled 100 patients with de novo coronary lesions 2.25 - 3.50 mm in diameter and length ≤ 27 mm in two 50 - patient cohorts for angiographic, intravascular ultrasound, and clinical assessment at nine or 24 months, with optical coherence tomography (OCT) performed in a subset of 30 patients at multiple time periods.

The rationale for an observational approach is to avoid the morbidity of lymphadenectomy (specifically to avoid the possibility of lymphedema) for two subsets of patients who never manifest isolated recurrence in the lymph node basin: those who have no melanoma remaining in the nodal basin and those who experience distant treatment failure at or before the time of nodal recurrence.

The fusion of these two genes was observed in just three percent of tumors studied, so any therapy based on this particular genetic aberration would apply to only a small subset of glioblastoma patients.

But that optimism, plus the availability of FDA - approved drugs with an HDAC inhibitory effect, has also prompted many families to find doctors who will prescribe these drugs, without knowing whether they work, or at what doses, or in which subset of patients.

The paper, «Perturbations in the lipid profile of individuals with newly diagnosed type 1 diabetes mellitus: lipidomics analysis of a Diabetes Antibody Standardization Program sample subset,» published in Clinical Biochemistry, described lipidomics (see sidebar) analyses of blood samples from patients recently diagnosed with type 1 diabetes mellitus (T1DM).

Overall, despite the dramatic therapeutic advances made elsewhere in the melanoma field, the poor prognosis of patients with mucosal melanoma mandates continued emphasis on laboratory and clinical research efforts in this rare subset of disease.

[44] Two other phase II clinical trials evaluated the efficacy of imatinib in patients with melanoma — including mucosal melanomas — harboring KIT mutations and / or amplifications, with a subset of cases involving mucosal primaries, and both found a disease control rate of approximately 50 %.

The third paper in the issue of the Journal of Clinical Oncology describes an analysis of a very rare subset of patients with low - stage disease and amplification of the MYCN oncogene.

It was heterozygous in most patients, homozygous in a subset as a result of mitotic recombination, and arose in a multipotent progenitor capable of giving rise to erythroid and myeloid cells.

Characterized as a biological subset of PTCL - NOS, patients with dysregulation of the histone modification machinery may be amenable to therapeutic intervention with HDAC inhibitors, given either alone or in combination with hypomethylating agents.