Sentences with phrase «cxcr4 cell surface»

CXCR4 cell surface and intracellular expression was detected by flow cytometry after co-staining with the N - terminal specific CXCR4 antibody 4G10 and the extracellular loop (ECL) specific antibody 12G5 whose epitope includes the CXCR4Δ18 deleted residues [42].

Next, we characterized CXCR4 cell surface expression over time by FACS.

Not exact matches

Using their novel approach, the scientists were able to disable a protein on the T - cell surface called CXCR4, which can be exploited by HIV when the virus infects T cells and causes AIDS.

For HIV to enter T cells, the virus first binds to a primary surface receptor CD4 and then to a coreceptor, either CCR5 or CXCR4.

As expected, CXCR4 could be detected on the surface of control cells by both the N - terminal and ECL antibodies.

CXCR4 may then be recycled to the cell surface or ubiquitinated by AIP4 that results in the lysosomal degradation of CXCR4.