Sentences with phrase «cancer cells in the bone marrow»

Not exact matches

The cancerous cells win out over the healthy blood cells in the bone marrow, which in turn leads to kidney problems when the cancer cells make abnormal proteins instead of antibodies.

Scientists are a step closer to creating blood stem cells that could reduce the need for bone marrow transplants in patients with cancer or blood disorders.

Patients were considered free of MRD if less than one cancer cell could be detected in 1,000 normal bone marrow cells.

Vitamin C may «tell» faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers.

Characterized by malignant alterations in the blood - forming stem cells in the bone marrow, ALL is the most common form of childhood cancer.

Researchers have designed a nanoparticle - based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

«We know multiple myeloma cells will anchor into bone marrow, and fat cells in the bone marrow will support the growth and spread of the cancer.

Researchers at Washington University School of Medicine in St. Louis have developed a nanotherapy that is effective in treating mice with multiple myeloma, a cancer of bone marrow immune cells.

Being overweight or obese has been known to increase the risk of multiple myeloma, a cancer of the plasma cells in the blood and bone marrow that develops more often after age 60.

Therefore, they not only kill cancer cells but also are toxic to other rapidly proliferating cells such as those in hair follicles and bone marrow.

Multiple myeloma is a cancer of plasma cells in the blood that causes tumor growths in bone marrow.

Aifantis, the chair of the Department of Pathology at NYU Langone and a member of its Perlmutter Cancer Center, and an early career scientist at the Howard Hughes Medical Institute, says experiments in his laboratory had shown that leukemia - initiating cells concentrate in the bone marrow near CXCL12 - producing blood vessels.

To determine whether endothelial cells — the cells that line the interior surface of blood vessels — directly influence breast cancer cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which endothelial cells formed blood vessel - like structures in culture as they would in the original organ.

In recent studies of cancer patients who received a bone marrow transplant, genes from the marrow's white blood cells were found in the patient's tumor cellIn recent studies of cancer patients who received a bone marrow transplant, genes from the marrow's white blood cells were found in the patient's tumor cellin the patient's tumor cells.

Given that breast cancer cells traveling through the bloodstream on their way to secondary sites where breast tumors metastasize most often — lung, bone marrow, brain and liver — must first pass through the basement membrane microvasculature, Ghajar and Bissell suspected that the basement membrane could be a major component of the dormant niche in distant organs.

The use of bone marrow - derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow - and adipose - derived stem cells are being evaluated.

Experience with lymphoma patients, who receive a transplant of their own blood or bone cells after radiation to wipe out their cancer, has shown «there's no doubt it helps,» says bone marrow transplant expert Nelson Chao of Duke University in Durham, North Carolina.

Dr. Cooper joined MDACC in 2006 as section chief of cell therapy at the Children's Cancer Hospital, where he cared for children undergoing bone marrow transplantation and led scientific efforts to develop new treatment approaches that pair genetic engineering with immunotherapies.

Multiple myeloma is a cancer of the infection - fighting plasma cells, part of the immune system found mainly in bone marrow.

According to Prof. Shaked, the drug caused inflammatory cells (macrophages) in the bone marrow to enhance the aggressiveness of the disease and provide the cancer cells with resistance to treatment.

The leading theory for this observation is that the foreign bone marrow cells can more easily recognize and attack cancer cells in their new host's body.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.

Now, in a study recently published in the journal PLOS ONE, a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of hCMV and the onset of graft - versus - host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant.

«One of the major limitations we see in treating blood cancers is the failure to clear cancer cells from the bone marrow,» said Flavia Pernasetti, PhD, of Pfizer Oncology Research and Development.

«We found that TRAF6 overexpression in mouse hematopoietic stem cells results in impaired blood cell formation and bone marrow failure,» said Starczynowski, a member of the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center.

However, a new study published in Cell Reports provides clues about how the dose of transplanted bone marrow might affect patients undergoing this risky procedure, frequently used to treat cancer and blood diseases.

In Germany, for example, the Munich - based biotech company apceth has already treated patients» gastrointestinal cancer with stem cells harvested from their own bone marrow and modified to convert a prodrug called ganciclovir.

In their report published in Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival timIn their report published in Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival timin Cancer Immunology Research, a team from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) describes how adding AMD3100 (plerixafor)-- previously approved for the stimulation of stem cell production prior to bone marrow transplantation — to their investigational drug VIC - 008 more than doubled the animals» survival time.

Mice injected with the blocker - treated leukemia cells, however, only exhibited cancer in 2 % of their bone marrow cells.

The cancer cells crowd out healthy cells in the bone marrow.

In 2014, the FDA approved Amgen's BLINCYTO ® (blinatumumab), the first BiTE ® therapy to receive FDA approval, for the treatment of Philadelphia chromosome - negative relapsed or refractory B - cell precursor acute lymphoblastic leukemia, a rare and rapidly progressing cancer of the blood and bone marrow.

Bone marrow transplantation (hematopoetic stem cell transplantation) can also be considered immunotherapy because the donor's immune cells will often attack the tumor or cancer cells that are present in the host.

In diseases like leukemia, a kind of cancer, the bone marrow produces abnormal blood cells.

Small Cell Lung Cancer (SCLC): Overexpression of CXCR4 is found in SCLC [30, 31, 37] and mediates the migration of SCLC to bone marrow along an SDF - 1 gradient [37].

In addition, the organs and tissues that possess high levels of SDF - 1, such as liver, lung, bone marrow, and lymph nodes, attract the migration of CXCR4 - expressing cancer cells [22].

Myeloma is a bone marrow cancer that starts in the plasma cells.

In this type of plasma cell neoplasm, less than 10 % of the bone marrow is made up of abnormal plasma cells and there is no cancer.

The largest number of adult stem cells is present in the umbilical cord blood and in bone marrow and they have been used effectively for decades to treat cancers, blood and immune disorders.

Her studies of the stem cells in bone marrow and their requirements for successful growth have contributed to advances in transplantation techniques that have saved the lives of patients with leukemia and other blood cancers.

The Blood and Bone Marrow Stem Cell Transplant physicians are members of the nationally renowned University of Chicago Comprehensive Cancer Center (UCCCC), one of only two National Cancer Institute (NCI)- designated Comprehensive Cancer Centers in Chicago.

Background In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005in early breast cancer (Braun, N Engl J Med 2005).

Dormant tumor cells in a hypoxic bone marrow niche (19) will be enriched for CSC in ER - α — positive breast cancer but depleted in ER - α — negative cancers profoundly influencing the capacity for late disease recurrence.

Of particular concern is the damage done to the blood - forming cells in the bone marrow which suppresses the immune system and promotes the development of secondary cancers like leukemia.

In other cases, people who have had had high doses of radiation or chemotherapy to destroy life - threatening cancer cells, the treatment can stop their bone marrow's ability to make blood cells.

Dr. Fred Appelbaum, director of the clinical research division at the Fred Hutchinson Cancer Research Center in Seattle, argued in an accompanying editorial that adult stem cells harvested from bone marrow rather than blood should be the norm.

Many forms of cancer liberate products into the bloodstream that suppress the formation of red blood cells in the bone marrow.

Changes in white blood cell counts can indicate infection or other pathological diseases that affect the bone marrow, such as certain forms of cancer.

There are many causes of anemia, including excessive blood loss due to trauma, immune - mediated diseases (when the body attacks its own cells or organs), cancer, genetic defects, kidney disease (or diseases in the other major organs), infectious diseases and bone marrow disease.

bone marrow or blood cell cancers such as lymphoma) Used in immune - mediated conditions (ex.