NCL, sometimes called canine ceroid lipofuscinosis in dogs, is a storage disease; toxins that the body normally would eliminate as waste build up in certain tissues.
In 2005 a nonsense mutation (c. 619C > T) in exon 4 in the canine CLN5 gene was reported to be linked to a specific form of Neuronal Ceroid Lipofuscinosis found in Border Collies.