President, Gladstone Institutes Director, Roddenberry Stem
Cell Center Senior Investigator & Director, Gladstone Institute of Cardiovascular Disease
Not exact matches
At EMD Serono, he was
Senior Vice President and Global
Senior Scientific Advisor in Immunology and Immuno - Oncology, facilitating major academic
center alliances and running the CAR T -
cell program in partnership with Intrexon.
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[email protected] 212-967-0322 x311
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«The newborn mice inherited a very altered, skewed population of microbes,» said Eugene B. Chang, MD, Martin Boyer Professor of Medicine at the University of Chicago, Director of the Microbiome Medicine Program of the Microbiome
Center, and
senior author of the study, published this week in the journal
Cell Reports.
«More women are postponing childbearing, but with age, the cumulus
cells that surround and nurture the eggs begin dying; we've found that this is caused by lack of oxygen,» said
senior author Pasquale Patrizio, M.D., director of the Yale Fertility
Center and professor in the Department of Obstetrics, Gynecology & Reproductive Sciences.
The discovery is an important advance in the search for new medications to fight obesity, said
senior investigator Shingo Kajimura, PhD, UCSF assistant professor of
cell and tissue biology, with a joint appointment in the UCSF Diabetes Center and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at U
cell and tissue biology, with a joint appointment in the UCSF Diabetes
Center and the Eli and Edythe Broad
Center of Regeneration Medicine and Stem
Cell Research at U
Cell Research at UCSF.
«The placement of the pegs that this group of
cells wraps itself around and then exerts force on each other is what dictates their alignment and the direction of the ECM they are going to synthesize,» said
senior author Jeffrey Morgan, professor of medical science and engineering and co-director of Brown's
Center for Biomedical Engineering.
«The best explanation for what we are seeing is that frequently, after exposure to HIV, a few
cells in the genital tract are infected, without establishment of a systemic infection,» says
senior investigator Eric Hunter, PhD, professor of pathology and laboratory medicine at Emory University School of Medicine, Emory Vaccine
Center, and Yerkes National Primate Research
Center.
Sheng Ding, PhD, a
senior investigator in the Roddenberry Stem
Cell Center at Gladstone and co-
senior author on the study, adds, «This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.
«We knew that ANG was involved in promoting
cell growth so it was not unexpected to find that ANG stimulates proliferation of myeloid progenitor
cells,» said Guo - fu Hu, PhD, Investigator in the Molecular Oncology Research Institute at Tufts Medical
Center, and the paper's
senior author.
«Heart calcification has been understudied and underreported,» says
senior author Arjun Deb, of the Eli and Edythe Broad
Center of Regenerative Medicine and Stem
Cell Research based at the University of California, Los Angeles.
Shinya Yamanaka, MD, PhD, a UCSF professor of anatomy and a
senior investigator with the UCSF - affiliated Gladstone Institutes, as well as the director of the
Center for iPSCell Research and Application (CiRA) and a principal investigator at Kyoto University, shared the Nobel Prize in 2012 for discovering how to make iPS
cells from skin
cells using a handful of protein «factors.»
«Certain subtypes of leukemia are very hard to treat and typically children with these subtypes have poor prognosis,» said Dr. Dinesh Rao, the study's
senior author and a member of the UCLA Eli and Edythe Broad
Center of Regenerative Medicine and Stem
Cell Research.
Some of these newly - discovered genes may help us better understand how a taste
cell detects a given taste quality,» said Monell
Center molecular neurobiologist Peihua Jiang, PhD, the study's
senior author.
«The treatment of multiple myeloma has improved significantly in recent years with the introduction of therapies such as proteasome inhibitors [which interfere with tumor
cells» protein - disposal system] and potent immuno - modulatory agents,» said the paper's
senior author and lead investigator, Paul Richardson, MD, clinical program leader and director of clinical research at Dana - Farber's Jerome Lipper Multiple Myeloma
Center, and the R.J. Corman professor at Harvard Medical School.
This pattern of adaptation is often seen in tumor
cells, according to J. Alan Diehl, Ph.D., the SmartState Endowed Chair in Lipidomics, Pathobiology and Therapy at the MUSC Hollings Cancer
Center and
senior researcher on the project.
«We think this could be one way cancer
cells actually migrate from one place to another to induce metastasis,» says Besim Ogretmen, Ph.D.,
senior author for this study, director of the Developmental Cancer Therapeutics Program at the Hollings Cancer
Center and professor of Biochemistry and Molecular Biology at MUSC.
«I'm a breast oncologist, and I've seen too many patients die from triple - negative disease,» said
senior author Andrei Goga, MD, PhD, professor of
cell and tissue biology and of medicine at UCSF, and a member of the Helen Diller Family Comprehensive Cancer
Center.
«Stem
cells function far differently in mice than in monkeys,» says biologist Shoukhrat Mitalipov, a
senior scientist in the Division of Reproductive and Developmental Sciences at Oregon National Primate Research
Center and lead author of the monkey study.
Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of
senior author Chi Van Dang, MD, PhD, director Abramson Cancer
Center, study body clock proteins associated with cancer
cells.
In fact, cadmium telluride solar
cells are currently the most ecofriendly devices, even though they use a toxic heavy metal, primarily because they require the least energy — typically provided by burning fossil fuels — to manufacture, says environmental engineer Vasilis Fthenakis,
senior scientist at Brookhaven National Laboratory's National Photovoltaic Environment Research
Center in Upton, N.Y., and Columbia University.
«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic
cells cooperate with uninfected dendritic
cells to activate T
cells and respond to the infection,» says infectious disease specialist and study
senior investigator Joel Ernst, MD, a professor at NYU Langone Medical
Center.
Tumors are home to diverse immune
cell types, some of which remain much less explored than T
cells and could also control cancer progression» says Mikael Pittet, PhD, director of the Cancer Immunology Program in the MGH
Center for Systems Biology and
senior author of the Science paper.
«Natural killer
cells are very attractive targets for immunotherapy because they are able to kill tumor
cells,» said Si - Yi Chen, M.D., Ph.D., a faculty member of the USC Norris Comprehensive Cancer
Center and
senior author of the study.
«Because of relatively low survival rates and their advancing age, these patients tend to be poor candidates for aggressive therapies, like a bone marrow transplant,» said
senior author Catriona Jamieson, MD, PhD, professor of medicine, chief of the Division of Regenerative Medicine at UC San Diego School of Medicine and director of the Stem
Cell Research Program at Moores Cancer
Center.
«We've known about these
cells blocking immune response for a decade, but haven't been able to shut them down for lack of an identified target,» said the paper's
senior author, Larry Kwak, M.D., Ph.D., chair of Lymphoma / Myeloma and director of the
Center for Cancer Immunology Research at The University of Texas MD Anderson Cancer
Center.
«Now that we know exactly how changes in EMSY spur cancer
cell growth, we can start to design therapies to specifically target that activity and hopefully stop it,» says
senior author Douglas Levine, MD, director of the Division of Gynecologic Oncology at NYU Langone and its Perlmutter Cancer
Center.
«A stem
cell's job is twofold: to replace or recreate mature cells that are lost over time, both through normal aging and after injury, and to replace themselves so that the process can continue over the life of the animal,» said senior author John Ngai, the Coates Family Professor of Neuroscience and a member of UC Berkeley's Helen Wills Neuroscience Institute and the Berkeley Stem Cell Cen
cell's job is twofold: to replace or recreate mature
cells that are lost over time, both through normal aging and after injury, and to replace themselves so that the process can continue over the life of the animal,» said
senior author John Ngai, the Coates Family Professor of Neuroscience and a member of UC Berkeley's Helen Wills Neuroscience Institute and the Berkeley Stem
Cell Cen
Cell Center.
«Reactive oxygen species are an essential part of the biochemistry of life,» says
senior author Gyorgy Hajnoczky, M.D., Ph.D., Professor at the MitoCare
Center of the Department of Pathology, Anatomy and
Cell Biology at the Sidney Kimmel Medical College of Thomas Jefferson University.
«The Gatm gene is needed for the synthesis of creatine, a substance made in the liver that travels to the barrier
cells and allows them to utilize energy in an efficient manner,» said Nobel Laureate Dr. Bruce Beutler, Director of UT Southwestern's
Center for the Genetics of Host Defense and
senior author of the study, which was published this week in the Proceedings of the National Academy of Sciences.
«There was some skepticism about whether a CD19 - directed therapy would work in this disease, since nearly all of these patients» cancerous plasma
cells do not express CD19,» said the study's
senior author, Edward Stadtmauer, MD, chief of Hematologic Malignancies and a professor of Hematology / Oncology in Penn's Abramson Cancer
Center and Perelman School of Medicine.
By matching normal and cancer
cells from a patient, we can now study the differences — what molecules are key to tumor development and growth, and, ultimately, match treatments that might disable this cancer,» says the study's
senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the
Center for
Cell Reprogramming (CCR) at Georgetown University Medical
Center.
«These findings give a rationale to start autologous transplantation — at least of neural
cells — in clinical situations,» says
senior author Dr. Jun Takahashi, of the Kyoto University's
Center for iPS
Cell Research and Application.
«Many questions remain, but the fact that these
cells can fully mature and grow for months post-transplantation is extremely promising,» added Dr. Willenbring, associate director of the UCSF Liver
Center and the paper's other
senior author.
The study was published in the journal Nature
Cell Biology by
senior author April Pyle, associate professor of microbiology, immunology and molecular genetics and member of the Eli and Edythe Broad
Center of Regenerative Medicine and Stem
Cell Research at UCLA.
«Patients whose AML
cells express FLT3 - ITD are among the highest risk group of patients with AML,» says the study's
senior author, Kimberly Stegmaier, MD, of Dana - Farber / Boston Children's Hematologic Malignancies
Center.
The researchers were led by P. Michael Conn, Ph.D., who was a
senior scientist in reproductive sciences and neuroscience at OHSU's Oregon National Primate Research
Center and professor of physiology and pharmacology,
cell biology and development and obstetrics and gynecology at OHSU for the past 19 years.
Further, its side effects are intolerable for many patients, limiting its use and creating an urgent need for more targeted drugs with minimal risks,» said Evan Snyder, M.D., Ph.D., professor and director of the
Center for Stem
Cells and Regenerative Medicine at SBP, and
senior author of the study.
We found how one of these mutations works,» said Zylka,
senior author of the
Cell paper and member of the UNC Neuroscience
Center.
«Salmonella strains have a natural preference for infiltrating and replicating within the cancer
cells of a tumor, making the bacteria an ideal candidate for bacteriotherapy,» said Robert Kazmierczak, a
senior investigator at the Cancer Research
Center and a post-doctoral fellow in the Division of Biological Sciences in the MU College of Arts and Science.
«This approach for data integration will enable the comparison of single -
cell datasets and the ability to dissect the differences between them,» explains Rahul Satija, the study's
senior author, who is an assistant professor in NYU's
Center for Genomics and Systems Biology and a core faculty member at the New York Genome
Center.
«Therapies for metastatic prostate cancer are urgently needed,» said Dr. Owen Witte, founding director of the Eli and Edythe Broad
Center of Regenerative Medicine and Stem
Cell Research at UCLA, university professor of microbiology, immunology and molecular genetics at the UCLA David Geffen School of Medicine, and a
senior author of the paper.
«We found that exomeres are the most predominant particle secreted by cancer
cells,» said
senior author Dr. David Lyden, the Stavros S. Niarchos Professor in Pediatric Cardiology, and a scientist in the Sandra and Edward Meyer Cancer
Center and the Gale and Ira Drukier Institute for Children's Health at Weill Cornell Medicine.
In part, the
Center builds on pioneering work done by Gladstone
Senior Investigator Shinya Yamanaka, MD, PhD — who currently divides his time between Gladstone and Kyoto University's
Center for iPS
Cell Research and Application (CiRA).
Now in experiments in mice reported this week in
Cell Metabolism, researchers at Joslin Diabetes Centers have highlighted the ways in which the host's genes interact with the microbial genes to create such conditions, says
senior author C. Ronald Kahn, M.D., Chief Academic Officer at Joslin Diabetes
Center and Mary K. Iacocca Professor of Medicine at Harvard Medical School.
Srivastava, who pioneered the use of stem
cells for heart disease, is director of the Roddenberry Stem
Cell Center and a
senior investigator at the Gladstone Institutes.
Moderated by: Hossam Badrawi, Chairman Nile Badrawi Foundation for Education & Development, former Chairman of the Committee on Education and Scientific Research, Parliament of Egypt Ernesto Fernandez Polcuch,
Senior Programme Specialist Natural Sciences, UNESCO Aicha Bammoun, Programme Specialist, Science Directorate, ISESCO Paul Rübig, Chair, European Parliament's Science and Technology Options Assessment (STOA) Liliya Hrynevych, Chairperson, Committee on Science and Education, Parliament of Ukraine Jesus Hurtado, Member of the Commission on Science, Innovation and Technology, Congress of the Republic Peru Ninlawan Petcharaburanin, Advisor for the Committee on Science Technology National Assembly, Thailand Rana Dajani, Associate Professor, Hashemite University, Jordan; Visiting Professor, Yale Stem
Cell Center and University of Cambridge
Rohit N. Kulkarni, M.D., Ph.D.,
Senior Investigator in the Section on Islet
Cell and Regenerative Biology at Joslin Diabetes
Center and Professor of Medicine at Harvard Medical School.
«Our study acknowledges the importance of T
cells in an environment where most people are focused on antibodies,» says the study's
senior author, Sujan Shresta, Ph.D., an associate professor in the
Center for Infectious Disease.
If we could find therapies that detect complications at an early stage, people with diabetes could lead healthier, more productive lives,» says
senior author Rohit Kulkarni, M.D., Ph.D., Principal Investigator in the Section on Islet
Cell and Regenerative Biology at Joslin Diabetes
Center and Associate Professor of Medicine at Harvard Medical School.