Sentences with phrase «cell homeostasis in»

Canonical Wnt Signaling in CD11c + APCs Regulates Microbiota - Induced Inflammation and Immune Cell Homeostasis in the Colon — Daniel Swafford — The Journal of Immunology

Canonical Wnt Signaling in CD11c + APCs Regulates Microbiota - Induced Inflammation and Immune Cell Homeostasis in the Colon

Not exact matches

If this gene plays a role in energy homeostasis and energy balance in the context of obesity, Wang reasoned, perhaps it could play a role in the energy requirements of liver cancer cells.

CTL1 is also found in animal cells, Chao noted, and thus the study concluded that «characterizing CTL1 as a new regulator of protein sorting may enable researchers to understand not only ion homeostasis in plants but vesicle trafficking in general.»

«In the study we challenged the view that the age - dependent impairment in glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of MiamIn the study we challenged the view that the age - dependent impairment in glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of Miamin glucose homeostasis is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it is instead affected by systemic aging factors,» says first author Joana Almaca at the Diabetes Research Institute, University of Miami.

«While expanding beta cell mass may still be desirable for future diabetes therapy, improving the local environment of the otherwise healthy aged beta cell could prevent age - associated deterioration in glucose homeostasis and thereby promote healthy ageing, which is conceptually novel and highly exciting,» says Per - Olof Berggren.

Recently, researchers have begun to describe the function of autophagy, a cellular recycling process critical for homeostasis, in germline stem - cell proliferation of C. elegans.

«Clarifying the interplay between bone cells in bone remodeling: Spatiotemporal intercellular interactions between mature osteoblasts and mature osteoclasts in bone homeostasis in vivo demonstrated.»

«The worm was initially used as a model to study embryology and neurobiology, and starting in the late 1990s research expanded into stem cell biology, tissue homeostasis, and regeneration, topics that are still very actively studied today,» he says.

This study demonstrated that emulsifier - induced alterations in the microbiome were necessary and sufficient to drive alterations in intestinal epithelial cells» homeostasis, which is thought to govern tumor development.

The effects of consuming emulsifiers were eliminated in mice devoid of microbiota (germ - free mice), and transplanting microbiota from emulsifier - treated mice to germ - free mice was sufficient to transfer alterations in intestinal epithelial cells» homeostasis, suggesting a central role played by the microbiota in tumor development.

Our findings demonstrate that induction of IAPP misfolding and aggregation by administration of preformed IAPP - aggregated seeds leads to the development of marked T2D - like pathology, including severe hyperglycemia, impaired glucose homeostasis, loss of β cells, and changes in islets morphology.

The topic that we are now working on is copper homeostasis and the trafficking of membrane copper - transporting ATPases in polarized cells.

His laboratory investigates how cell type specific differences in protein synthesis and homeostasis promote tissue regeneration and suppress the development of cancer.

Li Qiang, PhD, Pathology & Cell Biology, will receive $ 2,000,000 over five years from the National Institute of Diabetes and Digestive and Kidney Diseases for «PPARgamma Deacetylation in the Restoration of Metabolic Homeostasis.»

We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).

RhoA is down - regulated at cell — cell contacts via p190RhoGAP - B in response to tensional homeostasis.

CD4 + regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.

Bruno Pereira, University of Porto, Institute for Research and Innovation in Health - IPATIMUP - RNA - binding protein MEX3A role on intestinal stem cell homeostasis and implications for cancer

They study the mechanism of genome organization in development, homeostasis — metabolic balance — and aging; and the influence of cell morphogenesis, or cell shape and steructure, on cell fate decisions.

The lipids have for long remained in the shadow of DNA, RNAs and proteins, a revolution for biological research in the last 40 years, which provided rapid venues to understanding cell function and homeostasis.

For setting cancer in the context of ageing tissue, study of normal adult homeostasis is important — we are studying mutational processes, clonal dynamics and cellular competition in thousands of non-cancerous cells and samples from a range of tissue types, in health and disease.

Intracellular pH homeostasis during cell - cycle progression and growth state transition in Schizosaccharomyces pombe.

Effects of palmitate on ER and cytosolic Ca2 + homeostasis in β - cells.

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8 + T cells.

Modulation of insulin signalling and calcium homeostasis by endosomes in pancreatic beta - cells.

Dr. Semenza's research interests include the molecular mechanisms of oxygen homeostasis; gene and stem cell therapy for ischemic cardiovascular disease; the role of HIF - 1 in cancer; and protection of the heart against ischemia - reperfusion injury.

The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium / phosphate homeostasis.

We are part on the newly launched NIHR Blood and Transplant Research Unit in Donor Health and Genomics, where we coordinate theme 1 - Determinants of donation - related biomarkers.This theme will address the NIHR BTRU mandate to identify and characterise «genetic, biochemical, lifestyle and other determinants of relevant blood cell traits... and measures of iron homeostasis, including determinants of the trajectories of these factors over time among donors».

He and his lab study stem cell biology to provide insights into many areas, such as developmental biology, homeostasis in the normal adult and recovery from injury.

We will study how signaling mechanisms impact homeostasis in cell - free, cell - based, and organismal systems, with a particular focus on the highly topical role of autophagy in different processes and studying autophagic mechanisms in depth.

stem cell therapy for ischemic cardiovascular disease; Molecular mechanisms of oxygen homeostasis; Genetic syndromes due to mutations in genes encoding transcription factors

The outcome of a given division is unpredictable, but in homeostasis the probabilities of producing two progenitor and two differentiating daughters are the same, so that on average, equal numbers of progenitors and differentiating cells are produced across whole population of progenitors.

Dissecting the roles of mitochondria in stem cell homeostasis and differentiation is essential to understand stem cell dynamics and fate.

Peroxynitrates results in lipid peroxidation of membranes and cause disturbances in tissue homeostasis that is severe enough to cause cellular damage and eventually cell death (Beattie et al., 2000).

Up - regulation occurs when a cell is deficient in some kind of receptor so that more receptor protein is synthesized and transported to the membrane of the cell and thus the sensitivity of the cell is brought back to normal, reestablishing homeostasis.

Cell polarity is fundamental to the development of multi-cellular organisms, playing a central role in proliferation, cell fate diversification and tissue homeostasis or morphogeneCell polarity is fundamental to the development of multi-cellular organisms, playing a central role in proliferation, cell fate diversification and tissue homeostasis or morphogenecell fate diversification and tissue homeostasis or morphogenesis.

He presented results from both SMA mouse models and patients that demonstrated SMN depletion results in muscle - intrinsic defects such as reduced satellite cell number, a delay in the myogenic program, reduced myoblast fusion, and molecular homeostasis disruption.

In the case of cellular amino acid homeostasis, many examples will be drawn from cancer cells, for which the understanding is more complete than for other cell types.

We then examined whether VPA regulated immune homeostasis and ameliorated GVHD through inducing apoptosis of CD4 + T cells in vivo.

CONCLUSION: A pronounced shift in peripheral T - cell homeostasis was observed in CAD patients.

The researchers found that loss of collagen VII not only affected the composition of the cellular microenvironment but also led to global changes in cell homeostasis on mRNA and on protein level.

We use gut as model system to study cell migration in homeostasis, wound healing and cancer invasion (Fig. 1).

Cell migration in gut homeostasis and wound healing.

HIF proteins play a central role in oxygen homeostasis in cells and are subject to rapid half - lives and oxygen dependent proteasomal degradation.

Aberrant regulation of the epigenetic information results in changes in cell fate decisions, thereby affecting development and tissue homeostasis, and ultimately leading to disease, such as cancer.

Recently, it has been reported that glucose parameters were altered in mouse offspring produced by in vitro fertilization, intracytoplasmic sperm injection, and somatic cell nuclear transfer and that the effect was sex dependent, suggesting a sex - specific effect of in vitro exposure to media and / or mechanical manipulation on glucose homeostasis in offspring [37].

Within this ecosystem, innate and adaptive immune cells maintain and protect tissue function, integrity, and homeostasis upon changes in functional demands and diverse insults.

The center brings together leading experts in the diverse fields of neurobiology, stem cell biology, protein homeostasis, proteomics, functional genomics, and clinical neuropathology.

Programmed cell death is essential in organ development and tissue homeostasis and its deregulation is associated with the development of several diseases in mice and humans.