Not exact matches
The researchers were surprised to find that knockdown of one specific mitochondrial
chaperone, mtHSP70, elicited a unique
stress response mediated by fat accumulation, resulting in improved protein folding in the interior or cytosol of the
cell.
Research interests: protein and RNA transport, nuclear function and organization,
stress, signaling,
chaperones, nanobiology, stem
cell biology, microscopy, quantitative image analysis, high - throughput screening.
Cell Stress and
Chaperones, 1 — 13.
Current efforts focus on elucidating the role of molecular
chaperones compartmentalized in mitochondria in regulating tumor bioenergetics, adaptation to cellular
stress and
cell survival.
Oyer is now a postdoc at Drexel University studying Sigma 1, a so - called «
chaperone protein» that influences other proteins and pathways involved in the amount of
stress cells endure.
These pathways stimulate the production of protein
chaperones, neurotrophic factors and antioxidant enzymes, all of which help
cells cope with
stress and resist disease.