Sentences with phrase «cell culture studies showed»

Cell culture studies showed that the mutations» effects could be reversed with a drug compound known as a phospholipase inhibitor.

Not exact matches

In 2010, researchers from the University of Michigan Comprehensive Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor cells.

A small body of research that includes animal and cell - culture studies, however, shows that some of them can bind to hormone receptors.

In the study, the researchers show that after two to four weeks of 3 - D culture, the resulting muscle cells form muscle fibers that contract and react to external stimuli such as electrical pulses and biochemical signals mimicking neuronal inputs just like native muscle tissue.

«This pilot study showed that the culture system not only allowed for efficient propagation of sperm stem cells, but also eliminated ALL cells,» said Sadri - Ardekani.

Their study, which appears as a letter in the Sept. 8 edition of Nature Medicine, expands on work published in April showing that a combination of ribavirin and interferon - alpha 2b stops MERS - CoV from replicating in cell culture.

A previous study of VTT has shown that cell cultures have high contents of polyphenols that are known for their health - promoting effects (Ref.

They showed in previous studies with cell cultures that when adding RK - 33 to malignant lung and other cancerous cells that highly express DDX3, proliferation slowed or halted, and the cells» ability to form colonies was impaired.

Now that they have shown how this defense mechanism works in cultured cells, they hope to study the importance of LINE - 1 jumping and the defenses against it in specific diseases.

A protein that normally protects cells from environmental stresses has been shown to interact Marburg virus VP24, allowing the deadly Marburg virus to live longer and replicate better, according to a cell culture study led by scientists at the Icahn School of Medicine at Mount Sinai.

A new study shows coibamide A has potent anti-cancer activity in mice and cell cultures that model brain tumors and triple negative breast cancer, two of the most aggressive and difficult - to - treat types of cancer.

The test drug slowed the growth of kidney cysts in two mouse models and in cell cultures of human kidney cysts, the study showed.

Cell - culture studies show that when telomeres can no longer shield chromosomes from damage, cells stop dividing or become unstable.

However, chondrogenesis assays in chick micromass cultures showed that enhanced signaling by the mutant R206H ACVR1 can be partially inhibited by the BMP antagonist Noggin, suggesting that in addition to BMP - independent activity by the R206H ACVR1 receptor, this mutant receptor is also responsive to BMP, consistent with previous BMP signaling pathway studies that used cells derived from FOP patients (48 — 50).

In keeping with this, recent studies showed that flavanols, a subclass of flavonoids that is richly represented in natural cocoa beans, increase NO production by cultured human vascular endothelial cells (16) and improve endothelium - dependent vasorelaxation (NO - dependent) in finger (2) and brachial (3) arteries of healthy humans.

Studies of T cell differentiation have shown that in the presence of human MSC, Th1 cell secretion of IFN - γ dropped by 50 % compared to cultures without MSC.

Our study shows that selecting the appropriate cell line, growing the cells as 3 - D aggregates and infecting them when they are fully differentiated is key for successful in vitro cell culturing of human noroviruses.»

The present study shows that the basal glucose uptake as well as insulin - stimulated GS activity is reduced in satellite cell cultures established from patients with type 2 diabetes.

Previous studies of cell cultures from diabetic subjects cultured under basal physiological conditions showed that the basal as well as the insulin - stimulated FV0.1 values are reduced (4,5).

Previous studies of cell cultures established from diabetic subjects and cultured under basal physiological conditions showed that the basal as well as the insulin - stimulated FV values are reduced (4,5).

Results from this Shaffer Grant study also show that targeting antioxidants such as XJB -5-131 to the TM significantly attenuates expression and release of TGF - β2 from cultured human TM cells.

In contrast, previous studies have shown that Oct4 mRNA levels can remain relatively stable during DMSO - induced differentiation of P19 cells, although this has been ascribed to undifferentiated, highly proliferative cells present in the cultures following differentiation [22], [34].

A 2006 University of Florida study showed that extracts from açai berries destroyed cultured human cancer cells!

In a study involving dietary ketosis via a low carbohydrate diet (less than 10 percent of total calories), compared to subjects on a 50 percent carbohydrate diet, the low - carbohydrate subjects demonstrated better performance on memory tests, with higher scores being correlated to higher serum KB levels.14 A study using cultured mouse hippocampal cells showed that addition of the KB β - hydroxybutyrate (β - OHB) to cells exposed to Aβ resulted in no decrease in the numbers of dendrites or total neurons — two of the noted pathological changes in AD.

Cell culture studies also show that inflammatory cytokines increase both sebum and keratin production [1,8].

Resveratrol also decreases phase III protein synthesis and a study showed that in a cell culture this prevented acute myeloid leukemia cells from becoming resistant to the chemotherapy drug doxorubicin (24).

Antioxidants have been shown to reduce bio-markers of oxidative cell damage in cell culture systems, as well as in many animal models and human studies.

In fact, in one study, a dose of mercury sufficient to kill 1 percent of lab rats (lethal dose «LD01»), when combined with a dose of lead sufficient to kill 1 percent, killed 100 percent of the rats.13 A similar test involving mercury and aluminum in cultured neurons killed 60 percent of the cells when the two low - dose toxicants (LD01) were combined.14 Even antibiotics have been shown to enhance the uptake, retention and toxicity of mercury.14 Additionally, testosterone appears to aggravate mercury toxicity during development, while estrogen protects against it.15 This may explain why more boys than girls are diagnosed with autism spectrum disorders and attention deficit disorders.

Flavonoids have been shown to reduce biomarkers of oxidative cell damage in cell culture systems, animal models and human studies.