Sentences with phrase «cell entry of»

The antiviral restriction factor IFN - induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans.

[Xinghua Shi et al., «Cell entry of one - dimensional nanomaterials occurs by tip recognition and rotation»] As nanotubes may have medical applications, making them safe is key.

Not exact matches

CRAC channels control the entry of calcium into immune and other cell types, and calcium is an important intracellular signaling molecule that modulates cytokine production and the immune response.

New technology building booms and subsequent collapses are, historically normal and common following the introduction of new and transformative technologies, and we have seen them in the US and British automobile industries, the late 20th century communications «tech wreck», the rise and contraction cell phone manufacturers, and the explosion of entry into US telecommunications post «deregulation» in the US, just to cite a few.

So we can also contemplate this same unfolding and unified purpose of Christ in our own lives, from our conception as a simple cell, ensouled by God in accordance with the Unity Law, to Baptism and entry into Christ in the Eucharist, through the years of growing up and formation in holiness and the spiritual life — maybe through failure and re-conversion.

Some cells of this type have additional protection at the cable entry such as a glass - to - metal seal.

Oligosaccharides, which are simple chains of sugars, often contain domains that resemble the binding sites through which bacteria gain entry into the cells lining the intestinal tract.

Judging the entries were Bob Goldman of Northwestern University's Feinberg School of Medicine, Robert Krulwich, science correspondent for National Public Radio, Dave Mosher, science and technology correspondent for Business Insider, and Clare Waterman, of the Laboratory of Cell and Tissue Morphodynamics at the National Institute of Health.

Smith's group was one of the first to report the existence of a protein called SDI, better known as p21 — which helps inhibit a cell's DNA synthesis and thus initiates its entry into senescence — and Pereira - Smith worked with him on the project.

«We're talking about a technology with a low cost of entry that anyone with a cell phone can use.»

This protruding part of the antibody binds to a viral site that remains the same between strains, because the virus needs it to gain entry to a cell.

Dr Daniel Watterson, joint first author of the paper with Dr Jie Li, said that the antibody can block entry to the host cell, an essential step in the virus lifecycle.

Only viruses that have mutated escape mechanisms from immune pressures are able to survive, but the mutations come at the cost of other aspects of viral fitness, perhaps inhibiting entry into cells or integration into cell DNA.

A panel of small molecules that inhibit Zika virus infection, including one that stands out as a potent inhibitor of Zika viral entry into relevant human cell types, was discovered by researchers from the Perelman School of Medicine at the University of Pennsylvania.

«One of the functions of nicotinic receptors is to moderate the entry of calcium into cells.

Robyn Biti, Graeme Stewart of Westmead Hospital in Sydney, Australia, and colleagues report that they have found an HIV - infected homosexual man whose white blood cells contain a defective copy of a critical surface protein, called CCR5, that the virus uses to gain entry into the cells.

Last year, researchers at NIAID and elsewhere solved a decade - long mystery when they found that HIV uses a second set of proteins to gain entry into immune cells.

«Overall, the most important finding is that we identified nanchangmycin as a potent inhibitor of Zika virus entry across all cell types tested, including endothelial and placental cells, which are relevant to how Zika may enter the fetus,» Cherry said.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

He wanted to study the mechanism of viral entry into cells, and Ebola provided an interesting case.

Researchers at Harvard T. H. Chan School of Public Health and the Broad Institute have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

Prof. Hasan's group show that a process called SOCE (Store Operated Calcium Entry) which works to maintain calcium levels in cells could also play a role in maintaining the levels of dopamine, a vital neurotransmitter in the brain.

Scientists have identified a protein on the surface of human red blood cells that serves as an essential entry point for invasion by the malaria parasite.

The risk of developing severe malaria turns out to be strongly linked to the process by which the malaria parasite gains entry to the human red blood cell.

«The control of immune cell entry into the joint represents a major point at which new therapies could be developed to reduce the symptoms of inflammatory arthritis,» says Luster, who is the Harrison Professor of Medicine at Harvard Medical School.

Greber and his team infected human cells in culture with the chemically labeled viruses, and observed the behavior of the viral DNA during entry into cells.

Still others gain entry by disguising themselves as the sort of free - floating molecules that our cells routinely gobble up.

Researchers at Johns Hopkins have spotted a strong family trait in two distant relatives: The channels that permit entry of sodium and calcium ions into cells turn out to share similar means for regulating ion intake, they say.

When they inserted a fluorescent reporter protein in this virus - like shell, their test became capable of high - speed screening to see which drugs blocked the entry of Ebola - like viral particles into cells as measured by fluorescence.

These cells appear to be a major entry point for HIV infection of the brain.

If this modification of the protein entry gate can no longer take place, the process of cell division — and ultimately also growth — is slowed down.

As Harbauer demonstrated, the cell cycle - dependent modification of the protein entry gate leads to an increased import of proteins.

The study examined nanoparticle entry into endothelial cells and macrophages for the in vitro study, and the same type of cells from the lung, heart and bone marrow for the in vivo component.

Gangliosides are lipid molecules that were proposed to play key roles in numerous biological processes, including the formation of raft domains, the entry of toxins into cells and chemical signal reception.

«Making the movements of HIV visible so that we can follow, in real time, how surface proteins on the virus behave will hopefully tell us what we need to know to prevent fusion with human cells — if you can prevent viral entry of HIV into immune cells, you have won,» says Dr. Blanchard, who is also associate director of Weill Cornell's chemical biology program.

«Sumudu has shown that liver cells that express high levels of the IFITM proteins are resistant to infection with the hepatitis C virus by blocking entry of the virus into the cells,» Associate Professor Beard says.

The researchers have shown for the first time that antiviral proteins (the IFITM proteins) produced through the natural immune response block the entry of the hepatitis C virus into the cell.

In cells from sick hearts, these channels often don't inactivate properly, allowing for excess sodium entry and a build - up of calcium, which ultimately promotes abnormal heart rate (arrhythmia) and symptoms of heart failure.

However, as the spermathecal cells stretched upon entry of the egg, SPV - 1 detached from the straightened membrane.

The researchers also found that in nerve cells that detect short sounds, that ability is amplified by electrical properties of the nerve cell membrane's ion channels, which allow the entry and exit of charged chemicals.

They demonstrated that prohibitin found on the surface of motor neuron cells was involved in entry of EV71 into those cells.

In addition, the strain isolated from lions and hyenas during the 1993/1994 epidemic had rare mutations in two viral proteins: the CDV - H protein, which binds to the host cell receptor (called SLAM CD 150) and therefore plays an important role to facilitate viral entry into host cells, and the CDV - V protein, which enables the virus to manipulate the innate immune response of the host.

«In type 2 diabetes, glucose does not enter the cells and increased levels of insulin, resulting from an overburdened pancreas, do nothing to facilitate glucose entry into cells for producing energy,» Martins - Green said.

If approaches could be developed that specifically target expression of both CCR5 and CXCR4 on CD4 + T cells, virus entry should be inhibited more effectively.

They inhibit viral infection by preventing viral entry into target cells and by blocking different stages of the viral replicative cycle for different viruses.

In an elegant set of experiments, Südhof ruled out the possibility that loss of synaptotagmin impairs calcium entry into the cell or hinders some other event peripheral to calcium perception.

Molecular virology, cell biology of virus infection, HIV assembly and structure, virus entry and uncoating, viral proteases, antiviral drugs, resistance development, prevention of viral diseases

Additional experiments showed the feasibility of creating a two - layer security system for T cells by simultaneously blocking a gene the HIV virus needs to gain entry into cells and a gene the virus needs to survive and reproduce within the cell, resulting in doubly secure resistance.

Research Focus: My research focuses on the role of the herpesvirus entry mediator (HVEM) of by Innate Lymphoid Cells (ILC) and intraepithelial lymphocytes (IEL) in the Intestine.

Hemagglutinin (HA) and neuraminidase (NA) are the two predominant viral glycoproteins found in the viral envelope, and are the primary targets of the host immune system and are key factors in the entry and exit of influenza particles from host cells.