Not exact matches
Researchers at Boston Children's Hospital have, for the first time, visualized the
origins of cancer from the first
affected cell and watched its spread in a live animal.
My goal is to understand the genetic programs that allowed
cells in multicellular entities to evolve a germ - soma division
of reproductive labor in specific environments, not to analyze how our multicellular
origin has
affected the evolution
of our societies.
Such techniques have the potential to enhance research into the
origins of neurodevelopmental and neuropsychiatric disorders such as microcephaly, lissencephaly, autism and schizophrenia, which are thought to
affect cell types not found in the mouse models that are often used to study such diseases.
The specific vocation
of I - Stem is to explore all the therapeutic potential
of human pluripotent stem
cells for applications in patients
affected by rare diseases
of genetic
origin.
The
cell of origin also
affects tumor susceptibility to treatment.
My research is framed within the Wellcome Trust consortium on the archaeal
origins of eukaryotic
cell organization (http://evocyt.com/), which includes a diverse group
of researchers studying the evolution
of eukaryotic machinery from different points
of view — e.g. how do specific cellular systems work in different lineages, and how did that
affect the
origin of the eukaryotic
cell plan?
Utilising both chondrocytes as a starting material and non-integrating mRNA technology as a reprogramming strategy, the group aimed to remove the risk
of epigenetic memory
of somatic
cell of origin, which can
affect future differentiation propensity, and reduces the risk
of abnormalities being introduced during reprogramming.