Sentences with phrase «cell reprogramming involves»

Cell reprogramming involves making one cell type into another.

Not exact matches

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

It also should relieve the worries of the scholars involved with the journal Communio ¯ the use of oocytes in epigenetic reprogramming was one of the major reasons they feared the resulting cell was a disabled embryo.

Reprogramming involves inducing the expression of four factors, called Yamanaka factors, in cells.

There are now other methods to make stem cells, but those made via SCNT have unique value because they are genetic copies of the living person who donated the skin cells (other methods either use foreign cells or involve genetic reprogramming).

The scientists found that if they replaced MYC with LIN41 in the cocktail of genes involved in reprogramming — meaning if they used O, S, K and LIN41 — they could convert adult cells into iPSCs with the same efficiency.

«By identifying the areas of the genome that are directly involved in the reprogramming, we have also identified an important factor in the process — the gene regulatory protein KLF11 (Kruppel Like Factor - 11), which is found in all fat cells, and we have shown that it is required for the reprogramming to take place.»

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

'' (T) he immune response involves reprogramming the entire cell and also often the entire plant,» Cann said.»

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

This means that reprogramming process begins, there is no longer any room for chance; the genes involved are ready to be activated and enable the successful reprogramming of all the cells.

To overcome these limitations, Mooney's lab has been experimenting with a newer approach that involves reprogramming immune cells from inside the body using implantable biomaterials.

Scientists use OCT4 protein to reprogram adult cells into embryonic - like cells, an indication that it is involved in early development (SN: 11/24/07, p. 323).

Three teams of scientists reported earlier this year that they had directly reprogrammed adult mouse skin cells into embryonic cells, although the process involved viruses and cancer - causing genes.

In the new research, Prins and Liau used a technique called adoptive cell transfer, which involves extracting and growing immune cells outside of the body, then reprogramming them with a gene known as New York Esophageal Squamous Cell Carcinoma, or NY - ESO cell transfer, which involves extracting and growing immune cells outside of the body, then reprogramming them with a gene known as New York Esophageal Squamous Cell Carcinoma, or NY - ESO Cell Carcinoma, or NY - ESO - 1.

Japanese researchers report promising results from an experimental therapy for Parkinson's disease that involves implanting neurons made from «reprogrammed» stem cells into the brain.

«The idea of reprogramming a cell from your body to become anything your body needs is very exciting,» said Longaker, who emphasized that the work involved not just a collaboration between his lab and Wu's, but also between the two Stanford institutes.

The approach involves reprogramming skin cells into pluripotent stem cells, or cells that can give rise to any other fetal or adult cell type, and then inducing them to differentiate, or transform, into cells that perform a particular function — in this case, secreting insulin.

«Nuclear transfer involves the reprogramming of adult, differentiated cells and persuading them to act like early - embryo cells,» said Dr Griffin.

«If you're getting cells from these older donors, these seed cells that you use for reprogramming already have some accumulation of mutation load, and so that is actually very important evidence, especially when they are looking at the potential functions of these mutations,» University of California, San Diego, bioengineer Kun Zhang, who was not involved in the study, told The Scientist.

However, direct cellular reprogramming that does not involve a stem cell state solves some of the safety concerns surrounding the use of stem cells.

Before reprogramming can be applied to our own species to generate custom embryonic stem cells, scientists must be able to accomplish it without altering the DNA of the cells involved.

It only covers methods that involve introducing one or more reprogramming genes into an adult cell that has been genetically engineered to carry another pluripotency gene in its genome.

Researchers from the Morgridge Institute for Research and the Murdoch Children's Research Institute (MCRI) in Australia have devised a way to dramatically cut the time involved in reprogramming and genetically correcting stem cells, an important step to making future therapies possible.

The second strategy involves recruiting other retinal cells for reprogramming into RGCs.