Sentences with phrase «cell studied over»

Not exact matches

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

A Harris poll of phone owners found that nearly 10 % said their phone had been stolen at one point, and a recent study found that lost and stolen cell phones cost consumers over $ 30 billion last year.

Also there is evidence of molecular mechanisms in the cell membranes that can amplify small changes in the field to produce large changes in neural activity.13 On the other hand, earlier tests of Kohler's theory found that interference with electrical gradients over the cortex had no effect on behavioral measures (see note 11 for reference to these studies).

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In a group of patients who underwent surgery for epilepsy, over half had stem cells where healthy individuals do not have them, according to a study from Sahlgrenska Academy.

Through a variety of «high tech» approaches, including the isolation of monoclonal antibodies from single B cells and ultra-deep sequencing of shifting viral populations over more than three years of infection, the researchers studied one woman who developed potent broadly neutralizing antibodies.

«Our studies suggest that the local auxin signals can be communicated over long distances using calcium waves in order to generate an auxin signal also in target cells located far away,» Hedrich says.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

The study, published online July 31 in Cell Death and Disease, suggests a new approach to treating the estimated 3 million people in the U.S., and over 300 million worldwide, living with type 1 diabetes.

The study authors applied different concentrations of oleocanthal over three days to mouse brain cell cultures.

The innovative study, an effort of over 2 years by Lehner's group in collaboration with Gerald Hoefler and his team (Medical University of Graz, Austria), was published in scientific journal Cell Reports.

Early in their study, the team noticed differences between the expected 3BNC117 abundance in humans over time, given its half - life, and the actual abundance, a discrepancy hinting that some of the antibodies may be targeting not just circulating virus particles but HIV - infected cells as well.

Although many different malaria resistance loci have been postulated over the years, this is one of very few that have stood up to stringent testing in a large multi-centre study; the others include the genes for sickle cell and the O blood group.

Study participants will agree to allow researchers to track their mobile phone use over the next 20 to 30 years and to access their health records to look for correlations between cell phone use and health effects.

«Over the last decade, geneticists have identified hundreds of genetic risk factors for several human diseases, but the functional consequences of those factors on relevant cells are largely unknown,» said Towfique Raj, PhD, BWH Department of Neurology and a postdoctoral scholar at the Broad Institute, lead study author.

He also wants to study what happens when cells are exposed to conductive hearing loss over and over again, as happens in some small children.

Moreover, the observation that harmine inhibits DYRK1A in neural cells allows us to speculate about future studies to test its potential therapeutic role over cognitive deficits observed in Down syndrome and neurodegenerative diseases,» suggests Stevens Rehen, researcher from IDOR and ICB - UFRJ.

«Over the course of a person's life, with repeated exposure to bacteria and viruses, these T cells mature and eventually lose a protein called CD28,» said Gladstone Senior Investigator Melanie Ott, senior author of the new study.

Dr Sottile added: «This new system gave us an advantage over previous rodent models as we could study more accurately how specifically human cells would be affected by a decrease in temperature.

Genotoxic stress — the kind that can damage a cell's DNA — causes hair to whiten over time, according to a new study.

For almost 20 years, scientists all over the world have been studying the action of the stem cells and that of their controlling organizing cells.

By reinsulating damaged nerves and regenerating nerve cells, Schwann cell transplants have earned their stripes in paralyzed mouse, pig and primate studies over the past decade.

Geschwind, a professor in the Russell H. Morgan Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center, and others at Johns Hopkins have been studying the experimental drug as a cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer cells.

Michael Eisenbach and Martin Welch who work at the Weizmann Institute of Science in Rehovot, Israel, and Kenji Oosawa and Shin - Ichi Aizawa of Teikyo University in Japan, have studied a bacterium that has between 6 and 12 flagella spread randomly over the cell surface.

In this new study, researchers employed a cell - based reporter system to screen a collection of over 1000 gene - regulatory factors called microRNAs for the ability to influence this transition and identified some with particularly potent effects.

To examine how the availability of food may have affected armed conflict in Africa, the study relies on PRIO - Grid data from over 10,600 grid cells in Africa from 1998 to 2008, new agricultural yields data from EarthStat and Armed Conflict Location and Event Dataset, which documents incidents of political violence, including those with and without casualties.

Over the past few years, researchers have increasingly turned to stem cells to study various diseases in humans.

Large - scale storage of low - pressure, gaseous hydrogen in salt caverns and other underground sites for transportation fuel and grid - scale energy applications offers several advantages over above - ground storage, says a recent Sandia National Laboratories study sponsored by the Department of Energy's Fuel Cell Technologies Office.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

Because of this we were able to find differences in genome folding on the level of single cells: these cell - to - cell variations were missed in conventional Hi - C due to the averaging over millions of cells,» says Ilya Flyamer, former Vienna Biocenter (VBC) summer student and then Master student and one of the first authors of the study.

Based on meta - analysis of over 100 studies of transmembrane cell - surface receptors, as well as his own research, Prof. Maruyama proposed a new model for receptor activation — the «rotation model.»

The study used novel gene expression methods that allowed the researchers to identify over one thousand genes that are involved in the regeneration process of individual stentor cells.

They have generated excitement over the past few decades because scientists can study them in the laboratory to discover the genetic switches that control the development of specialized tissues in the embryo and fetus, and also because of their potential to replace body tissues that have broken down, such as pancreatic cells in those with diabetes or heart muscle cells in those with congestive heart failure.

Mouse study suggests strategy for gene - modified cells that can take over the liver — and heal rare diseases

The study, led by a team in The Research Institute at Nationwide Children's Hospital, is the first of its kind to show these results from an exon - skipping drug — a class of therapeutics that allows cells to skip over missing parts of the gene and produce protein naturally.

In his team's study, the most dramatic rebound in carried - over mtDNA occurred when the nucleus of a woman with mitochondria common among Europeans was inserted into the egg cell of a woman with mitochondria usually found in people with African ancestry.

These are all questions the researchers hope to answer by studying other kinds of life — such as prokaryotes, organisms devoid of cell nuclei, like bacteria — over longer periods of time, and even in different cities.

«Massive single - cell survey of kidney cell types reveals new paths to disease: Study of over 57,000 cells from mouse kidneys help identify human renal disorders.»

The study also demonstrates, contrary to what many suspected, that there was no rearrangement of DNA that would have prevented such cells from starting over.

The protective effect of the cells on rheumatoid arthritis decreased over time, with no benefit seen 15 years after a woman last gave birth, according to a study in Arthritis & Rheumatism published online March 2010.

The study's first six patients received 5 x 108 cells — more than 500 million of the modified cells — as a fractionated dose given over the course of three days, and five patients achieved a complete remission and one patient had a partial response to the therapy.

Current studies, such as those of Michael Reth, for example, indicate that these antennas are not randomly distributed over the surface of the cell.

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

He adds that the stem cells used in the study have advantages over reprogrammed skin cells, including eliminating the tricky business of inducing the cells to become muscle cells, but he notes that both types of cells could pose risks because the virus used to modify them could cause cancer.

Now a study has offered the first close - up look at just what happens over time to these cells.

Maintaining the chronological age of these cells is vital when studying neurodegenerative diseases that develop in people at different ages and worsen over decades.

In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over time.

«Using laser tweezers to study red blood cell invasion gives us an unprecedented level of control over the whole process and will help us to understand this critical process at a level of detail that has not been possible before,» says senior study author Julian Rayner of the Wellcome Trust Sanger Institute.

«Studying iPS cells that come directly from patients with the disease offers a major advantage over other models,» says Dr. Kulkarni.