«
Cell surface receptors for signal transduction and ligand transport - a design principles study.»
Not only did the cells churn out CRH, they also harbored
cell surface receptors for the hormone.
Not exact matches
At the end of September, the European Commission approved a marketing application
for Lutathera, a radioactive molecule that targets specific
receptors found on the
surface of neuroendocrine tumor
cells.
When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible
for encoding a protein that functions as a leptin
receptor: When it binds circulating leptin at the
cell surface, it sets in motion a biochemical cascade inside the
cell.
Called TSH
for short, this hormone attaches to a
receptor on the thyroid
cell surface, triggering a series of signals that provoke the gland to pump out thyroid hormones.
One key gene encodes the making of a
receptor called TREM2, a docking site
for molecules on the
surface of microglia and other innate immune
cells.
He determined that epithelial
cells lining the brain's blood vessel walls contain a
surface protein, or
receptor, that can snag insulin, the hormone essential
for metabolizing carbohydrates and fats.
Work is now continuing to study what transmitter substance and what
receptor on the
surface of the
cell are responsible
for the newly discovered timing mechanism.
A critical discovery in this research was finding that the novel progenitor has a
receptor protein on its
cell surface called KDR, or vascular endothelial growth factor
receptor 2, which until now, was thought to be restricted to endothelial
cells that form vessels, the progenitors
for endothelial
cells and the progenitors blood
cells.
«
Cell -
surface receptor offers promising breakthrough
for pancreatic cancer patients.»
They injected a mutant gene
for a
cell -
surface receptor for bmp into the right legs of two - day - old chicken embryos.
«The NILR1 is the genetic code
for a
receptor protein that is localized to the
surface of plant
cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.
Normally, antibodies that react to
surface receptors unique to the desired
cell are used
for this purpose.
MERS CoV (CoV stands
for coronavirus) has on its
surface an array of spike - shaped proteins that bind to host
cells — specifically to
receptor proteins called DPP4 on the
surface of
cells that line human airways.
Most resistance genes, in wheat and other plants, code
for protein
receptors located inside
cells; the Stb6 gene codes
for a
receptor protein on the
cell's
surface.
The networks provide structural integrity to tissues and serve as ligands
for integrin
cell -
surface receptors.
This in vivo reconstitution system provides a new approach
for examining ligand binding and G protein coupling to
cell surface receptors.
Once they found the match, the researchers had the D - peptides synthesized and tested
for their ability to activate their
receptors on the
cell's
surface.
Over the past 30 years, scientists have found that strong input to a postsynaptic
cell causes it to traffic more
receptors for neurotransmitters to its
surface, amplifying the signal it receives from the presynaptic
cell.
Now a team of researchers led by Philip Kim, a professor of computer science and molecular genetics in the University of Toronto's Donnelly Centre
for Cellular and Biomolecular Research, has developed a new technology
for making mirror - image peptides, which bind and activate
receptors on the
surface of
cells.
The scientists also found that endothelial
cells themselves give the signal
for their own death: To do this, the vascular wall
cells have a
receptor molecule called Death Receptor 6 (DR6) on their
receptor molecule called Death
Receptor 6 (DR6) on their
Receptor 6 (DR6) on their
surface.
Based on meta - analysis of over 100 studies of transmembrane
cell -
surface receptors, as well as his own research, Prof. Maruyama proposed a new model
for receptor activation — the «rotation model.»
Dr. Shiloh and his team currently are working to discover the human
cell -
surface receptors for Mtb that are involved in the bacteria's M -
cell translocation, as well as to determine the exact machinery used by the
cell to move the bacteria from the
surface to the bottom of the
cell.
For example, Dr. Shiloh said, preventing Mtb from attaching to
receptors on the M -
cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.
Both genes code
for proteins that function as growth factor
receptors, meaning they sit on the
surface of
cells and, when activated, can spur the rapid
cell growth that is a hallmark of cancer.
For HIV to enter T
cells, the virus first binds to a primary
surface receptor CD4 and then to a coreceptor, either CCR5 or CXCR4.
The authors catalogued several co-stimulatory molecules and
receptors present on the
surfaces of the PD -1-responsive T
cells, which possibly could be targets
for drugs.
To devise a potential new therapy, the investigators engineered a population of neural stem
cells to express a potent version of a gene called TRAIL, which codes
for a molecule that activates
cell - death - inducing
receptors found only on the
surface of cancer
cells.
Receptors are proteins that are usually located on the external
surface of the
cell membrane; they provide specific recognition sites
for messenger substances such as hormones, neurotransmitters and growth factors.
For example, T -
cells have a
receptor on their
surface called PD - 1, which acts as an off switch.
In a major innovation reported last year, Lerner, Zhang and their colleagues developed a basic method
for selecting antibodies that not only bind to a given target, such as a
cell -
surface receptor, but also have a desired biological function — such as activating the
receptor on mammalian
cells.
The team chose integrin
receptors that control a variety of functions on the
cell surface as a target
for their peptides.
D'Oro, U., Vacchio, M.S., Weissman, A.M. & Ashwell, J.D. Activation of the Lck tyrosine kinase targets
cell surface T
cell antigen
receptors for lysosomal degradation.
Byron B. Goldstein was recognized
for his contributions in the field of mathematical immunology and
cell biology, specifically in modeling
cell signaling cascades, pursuing cutting - edge research in
cell activation,
cell - signaling,
cell surface receptor - ligand interactions, and the generation of allergic responses.
The T4 glycoprotein is a
cell -
surface receptor for the AIDS virus.
Membrane cholesterol content accounts
for developmental differences in
surface B
cell receptor compartmentalization and signaling.
A conserved motif
for the transport of G protein - coupled
receptors from the endoplasmic reticulum to the
cell surface.
The
Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets
for both genetic and infectious diseases by using large - scale systematic approaches to discover
receptor - ligand interactions that are essential
for cellular recognition processes.
The BMP protein acts as an activator
for cell —
surface receptors, and initiates cellular processes and signaling cascades.
Asialoglycoprotein
receptor 1 is a specific
cell -
surface marker
for isolating hepatocytes derived from human pluripotent stem
cells.
Distinct Pathways
for the Trafficking of Angiotensin II and Adrenergic
Receptors from the Endoplasmic Reticulum to the
Cell Surface.
Current studies focus mainly on two
receptor systems - the mast
cell surface receptor, FcεRI, and the
receptor for epidermal growth factor that operate in immunological and
cell proliferation responses.
Also, genes that code
for receptor tyrosine kinases, a family of
receptors on the
surface of
cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.
When testing
for HER2, IHC assigns a score of 0 to 3 + to the amount of HER2
receptor protein on the
surface of breast cancer
cells.
Endocytosis has traditionally been viewed as a mechanism
for achieving signal attenuation: activated
cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.
Eventually this highly increase uptake
for galactose coated NP is due to a specific galactose
receptor on the
surface of
cells [23], [29].
For example, over 60 neuro - transmitters and hormonal
receptors have been found on the
surface of our disease - fighting immune
cells.
This powerful nutrient - partitioning agent significantly improves the insulin sensitivity of active insulin
receptors on the
cells»
surface for greater nutrient uptake and creatine saturation.
For example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate receptors on the surface of our cells that alter our metabolism, for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, lept
For example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate
receptors on the
surface of our
cells that alter our metabolism,
for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, lept
for example, activating
receptors on fat
cells to increase the expression of the weight - reducing hormone, leptin.
For insulin to work, it must bind to the insulin
receptor on the
surface of our
cells.