«Theranostics» Simultaneously Kill and Image Prostate Cancer
Cells Experimenting with human prostate cancer cells and mice, cancer - imaging experts developed a method for finding and killing malignant cells while sparing healthy ones.
Inverted microscope enables long term live
cell experiments with available perfusion and incubator for full environmental control.
Not exact matches
It's only been tested on mice so far, but the results are tremendously promising for an antibody Stanford researchers have been
experimenting with that blocks the body from «eating» cancer
cells.
As I stated in my original article, prior to conducting
experiments with human
cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees
with reasonable certainty that an embryo is not generated.
In various
experiments with various conditions, scientists have been able to create a wide range of
cell - like structures of increasing complexity on the road toward a simple self - replicating organism.
The researchers
experimented with inducing oxidative stress in a human
cell line culture
with and without VCOP (virgin coconut oil polyphenols) to observe how VCOP positively promoted catalase, a very important enzyme in protecting the
cell from oxidative damage, and glutathione (GSH), a self - recycling antioxidant produced by the liver.
You may sometimes need to
experiment with texture, because the very process of freezing causes any water in the food to expand, breaking down
cell walls.
In a preliminary
experiment, the team found that stem
cells produced from fibroblasts of men
with Klinefelter syndrome also lost the extra sex chromosome.
In
experiments with mice, the researchers found that Paneth
cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal
cells.
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Cells and Magnification, Menhusen Reading Activity - Formulating Hypothesis, Hebeisen Reading Exercise - Oersted's
Experiment, Schwartz Formulating Hypotheses - Levers, Schwartz North by Compass, North by Shadow, Dennis Controlling Variables - Human Heart Rate, Phillips Effect of Practice on Memorization, Forgetting and Relearning, Mayor Learning About Line Graphs I, II and III, Dean Controlling Variables - Chemical Reactions, Livermore Chances Are, Hebeisen Interpreting Data - Animal Behavior, Menhusen Working
with Solutions, Dean Defining Operationally - Inertia and Mass Stamp Out Trash, Hebeisen Interpreting Data Module - A Limited Earth: An Unlimited Population?
Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in
experiments, helped clear HSV - 1 infection in cultured human corneal
cells, in donated human corneas, and in the corneas of mice infected
with HSV - 1.
This method allows the scientists to measure very subtle effects
with very high confidence, while eliminating the effect of any genetic or epigenetic modifications and
cell culture related variations that could occur during the
experiment.
Focusing initially on
experiments that merged
cells, she built a career in gerontology and a successful working relationship
with her husband and research partner.
Other teams are trying to introduce the proteins encoded by the genes directly into
cells, while Yamanaka is
experimenting with «microRNAs» — snippets of RNA that help regulate gene activity.
Their next
experiment, Coles says, is to transplant the
cells into mice
with degenerating retinas to see if they restore function and later to figure out how to activate and manipulate them.
Despite the presumed virulence of the strain —
experiments with mouse lungs showed it produces 1000 times more bacteria in infected
cells than do standard varieties — Valway says the number of TB cases that developed were kept in line
with other typical outbreaks, which «shows that doing good contact investigations is important and preventative therapy works.»
Scientists have long
experimented with organs - on - chips: tiny representations of human organs, such as lungs, hearts and intestines, made from
cells embedded on plastic about the size of a computer memory stick.
Last year Cuervo collaborated
with Sheng Zhang, a professor at The University of Texas Health Science Center at Houston on
experiments showing that huntingtin — the Huntington's disease protein — helps the
cell's autophagy system identify what it should eliminate.
Dr. Zubair is working
with engineers at the University of Colorado who are building the specialized
cell bioreactor that will be taken to the ISS within a year for the
experiment.
When Lin's team repeated their
experiment with nerve
cells, they found that stimulating the quantum dots caused ion channels to open and the nerve
cell to fire.
Many other
experiments have been wrecked by contamination
with «impostor»
cells.
In one
experiment with human
cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.
In further test tube
experiments, the researchers treated the immortalized white blood
cells with both chemical and genetic blockers, called small interfering RNA (siRNA), designed to render either p70S6K or GRB10 nonfunctional.
Physicists who have revived
experiments from 50 years ago say nerve
cells communicate
with mechanical pulses, not electric ones
In another clue that cancer
cells persist because they maintain their telomeres, those
cells that started out
with longer telomeres in the
experiment lived longer than those
with shorter telomeres.
Researchers are also
experimenting with another form of immunotherapy called adoptive
cell transfer, which harvests and then reintroduces patients» tumor - infiltrating lymphocytes —
cells with anti-tumor capabilities that dig deep behind enemy lines.
«We showed that the coupling of
cell wall growth to mechanical strain is quantitatively consistent
with how bacteria recovered their shape after being deformed in
experiments.»
They report their findings, based on
experiments with cells and mice, in the September 2016 issue of Biomaterials.
Some of the
experiments included
cells from SMA patients, obtained through a collaboration
with Han Phan, MD, a pediatric neurologist at Children's Healthcare of Atlanta, and the Laboratory for Translational
Cell Biology at Emory.
In
experiments with human
cells, Shengdar Tsai of Massachusetts General Hospital and Harvard Medical School found that some guide RNAs nearly always lead Cas9 to the correct cutting site.
In
experiments with mouse ovaries inhibiting the identified enzymes saved the oocytes from
cell death despite treatment
with chemotherapeutics.
Several groups worldwide have done
experiments with ensheathing
cells in rats, some of which have been highly successful.
In a final
experiment, the group gave the animals a compound that prevented LPA from binding to its receptor on mouse brain
cells, right before they were injected
with hydrocephalus - inducing LPA.
A similar
experiment with salamanders started
with 6.7 x 107 J. lividum
cells per milliliter and the same concentration of Bd zoospores.
And in related
experiments, he made tadpoles grow eyes on their stomachs by changing the electrical properties of
cells to mimic those associated
with eye formation.
Domínguez - Bendala, who led the team along
with colleague Ricardo Pastori, found that BMP - 7 caused pancreatic
cells to secrete unexpectedly high amounts of insulin after they used it as a control in another, unrelated,
experiment.
Huang teamed up
with other researchers to do microfluidics
experiments, growing bacteria in tiny chambers and tracking individual
cells to learn how photosynthetic bacteria grow in light and dark.
Test tube
experiments showed that white blood
cells with the mutation responded more strongly to Il - 4 than did normal
cells.
Experiments in
cells with an inactivated form of Argonaute — which contributes only to the antiviral and not the gene regulation activity of RNAi — confirmed that they were observing an antiviral RNAi response.
Experimenting with human
cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection.
The team's further
experiments on cultured heart
cells confirmed that GDF - 11 stops the thickening growth seen
with age.
They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal
experiments, traced the pathway through which FER's binding to MET inside the
cell sets off a cascade of
cell - signaling events, all directly connected in prior research
with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.
Scientist Kenneth Ka - Ho Lee, who has been trying to reproduce STAP
cells and has been regularly blogging about his progress, has given up, writing «I don't think STAP
cells exist and it will be a waste of manpower and research funding to carry on
with this
experiment any further.»
Other groups are
experimenting with taking such tissue from the nose, growing it in the lab to isolate the desired
cells and transplanting them.
Mallat hopes to clarify the role of regulatory T
cells with a new
experiment: injecting the
cells into genetically normal mice
with atherosclerosis, to see whether the
cells can treat the disease.
Plasmons have been used in wafer - type
cells, but Pillai's group is the first to
experiment with them in thin films.
The researchers
experimented with mice that were genetically engineered to have light - sensitive proteins on some of their nerve
cells.
He had been
experimenting with human cancer
cells, microbes, and mothers» milk.
In the
experiment, Jiang's team fabricated a broadband active frequency - selective surface
with a stretching transformation pattern on a printed circuit board, and soldered the resistors and varactors between each of the two unit patterned
cells.
The
experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and specifically inhibits the growth of cancer
cells with mutant BRAF, both in vitro and in vivo.