Not exact matches
Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (
differentiate into osteoblasts,
chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.
Specifically, MSCs are usually confirmed to be MSCs by showing that they can
differentiate into three different, standard mesenchymal cell types: osteocytes (bone),
chondrocytes (cartilage), and adipocytes (fat).
In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can
differentiate into a variety of cell types, including adipocytes, osteoblasts,
chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.
Based on previous protocols [5, 6] they have now created a 3D protocol for chondrogenic lineage differentiation via the generation of a putative chondrogenic progenitor cell population, and have found that using this protocol C - iPSCs can be readily
differentiated into cartilage in a manner comparable to that of mature
chondrocytes [7].
Both control iPSCs derived from BJ fibroblasts (f - iPSCs) and
chondrocyte derived - iPSCs (C - iPSCs) were fully pluripotent and genomically stable (See figure), and were first
differentiated in a monolayer exposing the iPSCs in a defined, three stage manner to activin A, WNT3A, FGF2, BMP4, follistatin, GDF5, and neurotrophin 4.