Sentences with phrase «chromosome segregation errors»

Different levels of chromosome segregation errors have different consequences for tissues and organisms, ranging from oncogenic to tumor suppressive to lethal.

Combining this with various cancer models will reveal when and where certain levels of chromosome segregation errors impact organismal health and tumor development.

Not exact matches

The altered movement of the microtubules apparently contributes to errors in chromosome segregation, and so represents a new explanation for age - related infertility,» stated CRCHUM researcher and Université de Montréal professor Greg FitzHarris.

The researchers then confirmed that the number of singly paired chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related segregation errors could be tracked back to increased numbers of prematurely separated chromosome pairs.

To determine the most common type of age - related segregation errors, the researchers first used a novel high resolution imaging technique to visualize chromosomes in live mouse egg cells throughout the whole first stage of meiosis.

They found that chromosomes were always distributed correctly in young egg cells, but that a little less than 10 % of older cells suffered from segregation errors.

When there is more (polyploidy) or less (haploidy), mitosis is more prone to errors during the segregation of the chromosomes and this activates p53.

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

We wish to understand which mutations underlie this disease and how these mutations cause errors in chromosome segregation.

Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy.

Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis).

Aneuploidy is a manifestation of a Chromosomal Instability (CIN) phenotype: the tendency of a cell to make frequent errors in chromosome segregation.

Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.

Among these, errors of chromosome segregation lead to infertility.