Sentences with phrase «chronic activation of»

Interpersonal trauma, lack of stress - reducing secure attachment, and chronic activation of fear, often results in posttraumatic stress disorder (PTSD) in children.

Chronic activation of the sympathetic nervous system releases a stress - producing hormone called cortisol into the body.

However, as zebras don't usually worry about social and psychological stressors (like in - laws, the Middle East, dress sizes, or the stock market), and focus solely on physical stressors (like lions and twigs snapping suspiciously in the distance), they don't suffer the same chronic activation of stress response we do.

Chronic activation of the sympathetic nervous system releases a stress - producing hormone called cortisol into the body.

Chronic activation of the fear response can damage other parts of the brain responsible for cognition and learning.

Obesity promotes inflammation via chronic activation of the immune system7.

Uhm — You know, uh — the — the chronic activation of the Opioid receptors.

These findings suggest that muscle protein synthesis may be inhibited by chronic activation of the BCKDH complex, thereby promoting BCAA oxidation (19).

Inflammation is the chronic activation of our immune system caused by eating a high carb, high processed food diet, lack of proper nutrients, chemicals in our environment, the overuse of medications, and, high levels of stress.

«Chronic activation of the Stress Response impairs health,» according to an article by Harvard Health Publishing first published in March, 2011 and updated in March 2016.

Chronic activation of these stress hormones can harm our health over time, leading to symptoms like weight gain, chronic fatigue, and depression.

Obesity is associated with a low - grade inflammation of white adipose tissue (WAT) resulting from chronic activation of the innate immune system.

The data suggest a critical role of mitochondria in development of chronic activation of the immune response triggered by impaired redox control.

Dysregulation and chronic activation of these systems are also linked to immune deficiencies, disease, and neuronal death.

In the brain, it led to chronic activation of the immune system, even long after the viral infection had been cleared.

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

Chronic activation of this response could lead to a host of negative health effects, including cardiovascular problems.

Chronic activation of these autoreceptors revs up the activity of protein kinase A (PKA).

In contrast to this picture, the vast majority of HIV - infected AIDS patients, both adults and children, display all the signs of chronic activation of the immune system.

Not exact matches

Compared with healthy controls, patients with chronic fatigue syndrome had less activation of the basal ganglia, as measured by fMRI (functional magnetic resonance imaging).

The chronic dieters showed activations in areas of the brain associated with desire and expectation of reward, however.

«Our data suggest that individuals at high risk of developing recurrent intestinal tumors may benefit from chronic TRPV1 activation,» said Raz.

«In that way, we followed changes in the pleura throughout disease development, observing stages of chronic inflammation, activation of pro-oncogenic signaling pathways, and eventually inactivation and / or loss of genes that are the gatekeepers of cancer development,» MacFarlane says.

In the case of muscular dystrophy, the chronic cycles of muscle regeneration and degeneration that involve satellite - cell activation exhaust the muscle stem - cell pool to the point of no return.

«Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state of chronic immune activation and systemic inflammation seen in these patients,» said Dr. Jabs.

Kim Cecil, a chemist and professor of radiology at Cincinnati Children's Hospital Medical Center and an expert on the impact of lead on the brain, has found that whereas the language - function region of the brain's left hemisphere is perturbed by chronic lead exposure, corresponding regions in its right hemisphere show increased activation in the presence of blood lead levels above current levels of concern.

«This is not, in my mind, an approach to take during chronic infection, because once infection has been established, the mechanisms of immune activation become much more complicated,» observes Martin Markowitz, staff investigator at the Aaron Diamond AIDS Research Center in New York City.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

Electron microscopic observation in case of platelet activation in a chronic haemodialysis subject.

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

Immediate and lasting effects of chronic daily methamphetamine exposure on activation of cells in hypothalamic - pituitary - adrenal axis - associated brain regions.

The latter triggers a vicious cycle of persistent DDR and pro-inflammatory signals leading to chronic inflammation, tissue malfunction and degeneration with old age; in DNA repair - deficient patients, the rapid accumulation of DNA damage (in view of the DNA repair defect) would trigger the untimely activation of DDR signaling leading to the early manifestation of age - related pathology that is associated with chronic inflammation.

Cellular senescence is often fueled by nuclear DNA damage followed by chronic DDR activation; telomere shortening, mitogenic oncogenes, or intrinsic DNA damage can lead to different types of senescence limiting the replicative lifespan of cells.

Chronic schizophrenia patients showed a significant drop in activation of these regions, «thus it appears that they fail to engage these frontal regions,» said Belger.

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug - resistant chronic myeloid leukemia

Liang J, Nagahashi M, Kim EY, Yamada A, Huang WC, Hait NC, Harikumar KB, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, and Spiegel S. Sphingosine -1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis - associated Cancer.

Her lab explores the relationship between the aging of neural circuits, the accumulation of toxic proteins and the subsequent activation of a chronic inflammatory response.

It is also the first in an emerging class of therapies called «checkpoint blockade,» which enhance the immune system's ability to attack cancer by interfering with immunological checkpoints that slow or stop immune cell activation and proliferation in the presence of tumors or chronic viral infection.

The detrimental effects of chronic immune activation, which is the result of HIV infection, have become increasingly clear.

Inhibition of Dicer or Ago2 expression revealed that small RNAs are involved in an immediate response to demethylation - induced transposon activation, while the deposition of repressive histone marks follows as a chronic response.

The chronic stress of an unhealthy relationship can cause a long - term activation of our brain's CTRA, contributing to chronic inflammation and increasing the risk of health problems like adrenal fatigue.

Monteleone, P., et al, Blunting by chronic phosphatidyl serine administration of the stress - induced activation of the hypothalamo - pituitary - adrenal axis in healthy men.

The researchers divided the 220 children into two categories — those with mothers who reported a history of chronic immune activation (caused by asthma and allergies) and those with mothers who reported a diagnosis of an autoimmune condition, such as diabetes and thyroid problems.

Evidence for impaired activation of the hypothalamic - pituitary - adrenal axis in patients with chronic fatigue syndrome.

«Chronic Intermittent Fasting Improves the Survival Following Large Myocardial Ischemia by Activation of BDNF / VEGF / PI3K Signaling Pathway,» Journal of Molecular and Cellular Cardiology, 46 (3), 405 - 412.

Another more common example is cigarette smoke, which causes chronic inflammation in the lungs, producing oxidation (and free - radicals) and leads to DNA damage and chronic obstructive pulmonary disease as well as lung cancer.6 A hallmark of both of these processes in the activation of nuclear factor - Kappa B (NF - KB), which is a protein complex that the body produces in response to inflammation, free radicals, cytokines, all hallmarks of stress.

«Increases in inflammatory activity are a very adaptive response when you have them once in a while, but to have lots of these activations over the course of a day or a week could potentially lead to chronic levels of inflammation which can be damaging to other cells and to organs.»

One of the most recent theories on aging focuses on immune response, and takes into consideration the activation of subclinical, chronic low - grade inflammation which occurs with aging, named «inflammaging.»

''... chronic, stress - induced repeated activation of the LC may lead to an allostatic overload of the de-toxicant capacity of LC neurons.

Show Notes: [1:50]-- How a trip to Central America led to many years of chronic health issues [5:10]-- The symptoms that would lead to years of a long health struggle [11:30]-- Some of the conditions that Jennifer was diagnosed with; Chronic Fatigue Syndrome, Immune Deficiency Syndrome, Mast Cell Activation Syndrome, Lyme Disease, Interstitial Cychronic health issues [5:10]-- The symptoms that would lead to years of a long health struggle [11:30]-- Some of the conditions that Jennifer was diagnosed with; Chronic Fatigue Syndrome, Immune Deficiency Syndrome, Mast Cell Activation Syndrome, Lyme Disease, Interstitial CyChronic Fatigue Syndrome, Immune Deficiency Syndrome, Mast Cell Activation Syndrome, Lyme Disease, Interstitial Cystitis.