In the Old English Sheepdog, PCD affected dogs typically develop symptoms of respiratory disease a few days after birth and suffer from
chronic airway inflammation later in their life.
Cough Suppressants
Chronic airway inflammation causes production of lots of thick mucus, probably as a protective mechanism to trap the offending irritant from reaching the lung.
The World Health Organization defines bronchial asthma as
a chronic airway inflammation that is caused by various inflammatory cells, including eosinophils (EOS), mast cells and T lymphocytes (1 — 3).
Chronic airway inflammation is characterized by the infiltration of EOS, an increase in serum immunoglobulin (Ig) E and excessive secretion of airway mucus (4 — 6), which result in airway structural changes and may even develop into refractory asthma or severe asthma (7).
Not exact matches
Asthma, the most common serious
chronic disease among children, is an
inflammation and narrowing of the
airways that causes difficulty breathing.
It could be a critical target with significant therapeutic potential for suppressing
inflammation associated with
chronic airway disease.
Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of
chronic allergic
airways disease:
inflammation;
airway remodeling (structural changes that occur in lungs as a result of prolonged
inflammation); and
airway hyperresponsiveness (the clinical symptom of asthma).
Our finding of sinusitis, bronchial hyperreactivity, and bronchial responsiveness in firefighters with World Trade Center cough is important but not surprising.17 - 20 An unexpected finding was that 87 percent of such firefighters reported symptoms of gastroesophageal reflux disease; such symptoms are generally reported by less than 25 percent of patients with
chronic cough.1, 21,22 Despite the strong associations between gastroesophageal reflux disease and
chronic cough17 - 20 and between gastroesophageal reflux disease and asthma,23 - 25 it remains unclear whether gastroesophageal reflux disease causes either condition.26 The causative mechanism may be repeated aspiration of minute amounts of refluxed material; vagally mediated esophageal, tracheobronchial, or laryngobronchial cough reflexes; or neurally mediated bronchial
inflammation.23, 24,26 Involvement of the posterior nasopharynx is common in patients with gastroesophageal reflux disease, 27 whereas bronchial hyperreactivity may not be present.25, 26 For these reasons, we classified gastroesophageal reflux disease as an upper -
airway symptom (Figure 2).
Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J. «Effect of Hyssopus officinalis L. on inhibiting
airway inflammation and immune regulation in a
chronic asthmatic mouse model».
About Asthma Asthma is a
chronic condition resulting from
inflammation of the
airway.
Career Goals: Developing of novel immunotherapeutic strategies for the treatment of
chronic allergic
inflammation and
airway remodeling.
Children with asthma experience difficulty breathing as a result of
chronic inflammation of the
airways, which can be alleviated by inhaling drugs called bronchodilators that make the muscles lining the
airways relax, allowing them to reopen.
It's no secret that smoking is harmful, but it's been hard to study its effects on
chronic obstructive pulmonary disease (COPD), a disease that leaves sufferers short of breath thanks to
inflammation of the small
airways in the lung.
Asthma is a
chronic condition resulting from
inflammation of the
airway and lungs.
Patients with COPD have airflow obstruction that is caused either by destruction of the air sacs that exchange gas in the lungs (emphysema) and / or
inflammation of the
airways (
chronic bronchitis).
«COPD stands for two processes that almost always occur together:
chronic bronchitis, which is
inflammation of the
airways, and emphysema, which is destruction of the fine substance of the lung,» says Norman Edelman, MD, chief medical officer of the American Lung Association.
Symptoms are caused by
chronic inflammation and narrowing of the
airways going into and out of the lungs.
Asthma is a
chronic inflammation of the
airways in your lungs, tiny pockets called alveoli where oxygen and carbon dioxide are exchanged as you breathe.
Inflammation within
airways causes
chronic cough and excessive mucus production.
Feline asthma is similar to human asthma, in that it is a
chronic inflammation of the
airways inside the lungs.
The lack of coordination and ineffectiveness of the ciliary function result in a slow clearance of mucus from the
airways; this in turn results in
chronic mucus plugging and
inflammation of nasal cavities, trachea and lower
airways.
Chronic bronchitis is the most common cause of feline cough which is an
inflammation in the
airway between the nose and the lungs.