Sentences with phrase «chronic use of the drug»

Researchers found that chronic use of the drug kept the brain in this state of «chronic depression,» in essence suppressing the neural terminals controlling the flow of signals between the cortex and striatium — even after a long period of several weeks.

Add this to the list of reasons not to take cocaine: Chronic use of the drug may speed up the aging process.

While marijuana's «exogenous» cannabinoids also can reduce anxiety, chronic use of the drug down - regulates the receptors, paradoxically increasing anxiety.

Not exact matches

Potential subjects were accepted into the study if they had none of the following conditions: severe or symptomatic cardiac disease or hypertension; history of bleeding disorders; chronic history of gastric, intestinal, liver, pancreatic, or renal disease; any portion of the stomach or the intestine removed (other than an appendectomy); history of intestinal obstruction, malabsorption, or use of antacid drugs; cancer (active or use of medications for a history of cancer treatment within the past 5 y); history of chronic alcoholism; a convulsive disorder; or abnormal results in screening blood or urine samples.

Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women

In the heady postwar years, hundreds of promising studies were conducted in the United States, Canada, and Europe on the use of LSD and other psychedelics, like peyote, to treat such psychiatric maladies as schizophrenia, autism, drug addiction, alcoholism, and chronic depression.

People with chronic opioid use disorders are more likely to relapse and do so sooner if they are treated in a compulsory drug detention centre rather than a voluntary drug treatment centre using methadone maintenance therapy, according to the first study comparing the outcome of both approaches published in The Lancet Global Health.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..

While morphine continues to be one of the primary drugs used for the treatment of severe or chronic pain, it is often less effective in females.

Paul Ross, 60, has had 13 surgeries in the past 35 years, resulting in constant chronic pain and prescriptions for high doses of hydromorphone, which is used to treat severe pain that isn't controlled by other opioid drugs.

«Certain drugs are used to inhibit some of the same targets in patients with chronic pain, and those medications also may quiet down itch,» Chen said.

A clinical trial studying the use of Verapamil (a drug currently in use for cardiovascular disease and cluster headache) in alleviating chronic rhinosinusitis (CRS) with nasal polyps revealed significant improvement in the symptoms of this subset of patients.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

As their novel technique for drug delivery is non-invasive and easy to use, the NUS team envisioned that the microneedles patch has great potential for applications in clinical and home care settings for the management of perioperative pain and chronic pain in patients suffering from conditions like diabetes and cancer.

Dr Wenxin Wang is trying to uncover therapies for diseases such as diabetic ulcers and Epidermolysis Bullosa, which causes chronic skin conditions: «We are currently investigating the use of these new materials for biomedical applications such as drug / gene delivery, cross linkable hydrogel materials and skin adhesives.

In a study that appears in the May issue of the Journal of General Internal Medicine, researchers at Boston University School of Medicine and Boston Medical Center have found that the majority of patients misusing drugs and alcohol have chronic pain and many are using these substances to «self - medicate» their pain.

In elderly cancer patients like my father and aunt, who suffer from a variety of chronic health problems, physicians often modify standard treatment regimens — perhaps using two chemotherapy drugs instead of three or lowering standard dosages — in the hope that the revised treatment will work well enough.

Common risk factors include chronic diseases such as cancer or diabetes and use of immune - suppressing drugs.

«While the association between chronic pain and drug addiction has been observed in prior studies, this study goes one step further to quantify how many of these patients are using these substances specifically to treat chronic pain.

The lack of information about the long - term safety of drugs prescribed for children is a special worry, both for drugs that may be used for decades for chronic conditions and for drugs for which short - term use may be found to harm children's growth and development months or years later.

Steven Grant, a researcher at the National Institute on Drug Abuse, says that the new findings will help untangle a «chicken and egg problem» with human addiction studies: Previous research found a correlation between the D2 - family receptors and drug abuse, but it was unclear whether fewer receptors contributed to addiction or if chronic drug use led to a drop in the number of receptDrug Abuse, says that the new findings will help untangle a «chicken and egg problem» with human addiction studies: Previous research found a correlation between the D2 - family receptors and drug abuse, but it was unclear whether fewer receptors contributed to addiction or if chronic drug use led to a drop in the number of receptdrug abuse, but it was unclear whether fewer receptors contributed to addiction or if chronic drug use led to a drop in the number of receptdrug use led to a drop in the number of receptors.

Knowing how these small potassium channels work could help reduce the use of drugs in patients with chronic inflammatory pain.

Health effects of acute and chronic marijuana use remain controversial and the US Food and Drug Administration (FDA) has not officially approved marijuana as a medicine, nor has it been extensively studied within the general population.

The goals of the research areas are to understand the neurobiological mechanisms underlying drug abuse and addiction, with special emphasis on changes that occur during chronic drug use, withdrawal and relapse.

«Chronic exposure to drugs of abuse causes changes in the brain that could underlie the transition from casual drug use to addiction.

It can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

Dr. Vilcek's contributions to the understanding of proteins that control the body's defenses were instrumental in the development of the anti-inflammatory drug Remicade ®, the first member of a new class of therapeutics called TNF blockers that are now widely used for the treatment of Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, and other chronic inflammatory disorders.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of thChronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of thchronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational use of drugs, clinical pharmacology David J. Webb, UK - hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and drug utilisation

Opioid drugs used to relieve pain in postoperative and chronic cancer patients may stimulate the growth and spread of tumors, according to two studies and a commentary in the 2012 annual Journal Symposium issue of Anesthesiology, the academic journal of the American Society of Anesthesiologists.

A: It looks like about 60 % of patients with chronic pain have flairs that can be called breakthrough pain, and in the cancer population, the use of a short - acting opioid co-administered with a long - acting drug is the standard of care.

In both groups, researchers associated use of the drugs with an increased risk of chronic kidney disease over 10 years.

A 1984 study looked at the use of Fulvic / Humic acids in chronic bronchitis and found that these were as effective (or more so) than conventional drug therapies at alleviating symptoms.

Are a woman Have a family history of osteoporosis Are white Are thin Are short Went into menopause early Have a low calcium intake Don't exercise Smoke cigarettes Drink more than two alcohol drinks daily Are on chronic steroid therapy (e.g. Prednisone) Are on chronic anticonvulsant therapy Are taking drugs which can cause dizziness Are hyperthyroid Eat too much animal protein intake Use antacids regularly Drink more than two cups of coffee daily

Fatigue and chronic lack of rest and sleep, age, damaged capillaries (smallest blood vessels around the eyes), periorbital hyperpigmentation (increased melanin production beneath the eyes making the skin to appear darker), seasonal allergies, eczema, frequent use of stimulants such as caffeine, smoking, drugs and alcohol, poor skin elasticity and health, lack of antioxidants, diet high in sugar and other refined products, age, thinner skin beneath the eyes, etc..

1 - lack of relaxation 2 - devitalized food 3 - unfulfilling employment (dead - end jobs) 4 - dead - end relationships (romantic or not) 5 - surgery 6 - junk food 7 - trans fats and rancid fats 8 - financial stress 9 - sedentary lifestyle 10 - excessive exercise 11 - death of a loved one 12 - alcoholism 13 - smoking 14 - illicit drug use 15 - prescription drug use 16 - toxins 17 - poor eating habits 18 - marital stress 19 - repeated traumas 20 - workaholism 21 - nutritional deficiencies 22 - hormonal imbalances 23 - oral contraceptives 24 - stimulants 25 - counterproductive attitudes and beliefs 26 - conventional hormone replacement therapy 27 - non-prescription drugs 28 - psychological stress 29 - persistent fears 30 - emotional stress 31 - lack of sleep 32 - being in denial about feelings 33 - acute or chronic infection 34 - repeated stresses 35 - persistent negative stressors 36 - fun or enjoyment deprivation 37 - allergies 38 - caffeine 39 - white sugar and white flour products 40 - antacids 41 - artificial sweeteners and colors 42 - major life events — even if perceived consciously as «good» (e.g.: graduating high school, moving, etc..)

As a result, acupuncture is used for the treatment of acute and chronic pain without the use of drugs or surgery.

Increased mortality and cardiovascular morbidity associated with use of nonsteroidal anti-inflammatory drugs in chronic heart failure.

They are drugs, drugs that were initially developed by and for the military to treat acute mercury, lead and other poisonings of World War II army and navy personnel.2, 3 Their use for the removal of chronic levels of toxic metals is off label and controversial.

As was recently published in the journal JAMA Neurology, chronic use of these acid - blocking drugs is associated with a 44 percent increased risk for dementia.

After 5 years of producing no music (and enduring chronic pain and extended drug use), he's approached by a writer (Ian McGregor) whose effort for a story turns into much more.

But it isn't just chronic pain that is driving use of prescription painkillers; evidence suggests it is the sense of disconnect, of lost opportunity, of the dissolution of the traditional community in rural and remote parts of America, that is driving people to seek solace in drugs, both prescribed and otherwise.

The research team launched their study into four different stages to assess student coping skills, academic engagement, family engagement, expectations, mental health symptoms, and alcohol and drug use while discovering what the main cause of chronic stress was for today's youth.

States are able to use funds under Title I and Title II, Part A for a variety of different social and emotional strategies, including in - service training for school personnel about techniques and supports for SEL, such as referring at - risk students to mental health services, and addressing issues like safety, peer interaction, drug and alcohol abuse, and chronic absenteeism.

When we speak of addiction as a chronic disorder of the brain, it thus includes an understanding that some individuals are more susceptible to drug use and addiction than others, not only because of genetic factors but also because of stress and a host of other environmental and social factors in their lives that have made them more vulnerable.

In our veterinary hospital, the use of this spray has proven incredibly beneficial for dogs with chronic ear conditions, and especially those that are resistant to many traditional drugs and antibiotics.

Such drugs as fentanyl, hydromorphone, morphine, and buprenorphine are commonly used in veterinary hospitals for treatment of pain associated with trauma, surgery, post-op surgical pain management, and chronic diseases.

Pain management — this is a non-invasive therapy used instead of drug therapy for the treatment of chronic pain.