Sentences with phrase «clathrin endocytic»
Limited Transferrin Receptor Clustering Allows Rapid Diffusion of Canine Parvovirus into Clathrin Endocytic Structures.
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However, endocytic waves may be initiated by clathrin through a positive feedback mechanism between clathrin and downstream proteins which includes actin regulating proteins as well as membrane proteins such as PIP3.
The researchers observed that for such coordination between the endocytic and cortical waves, a feedback between downstream F - BAR / Cdc42 / N - WASP and clathrin was required.
The work, led by Assistant Professor Wu Min, showed how a major endocytic pathway mediated by the protein clathrin, was found to commence with periodic traveling waves of clathrin, which were coupled temporally and spatially to downstream cortical actin waves.
The feedback, which couples the initiation of endocytic waves by clathrin to cortical actin waves is analogous to a group of people walking on a wobbly bridge.
Using sensitive live cell imaging, the team noted that endocytic waves initiated by clathrin emerge in some cell populations.
Existence of a novel clathrin - independent endocytic pathway in yeast that depends on Rho1 and formin.
In vivo dynamics of clathrin and its adaptor - dependent recruitment to the actin - based endocytic machinery in yeast.
Distinct dynamics of endocytic clathrin - coated pits and coated plaques.
Novel function of clathrin light chain in promoting endocytic vesicle formation.
We thus propose a molecular hypothesis — termed the GL - Lect hypothesis — on how GlycoLipids and Lectins drive the formation of compositional nanoenvrionments from which the endocytic uptake of glycosylated cargo proteins is operated via clathrin - independent carriers.
The contribution of extracellular determinants to the construction of endocytic pits has received much less attention, depite the fact that (glyco) sphingolipids are exoplasmic leaflet fabric of membrane domains, termed rafts, whose contributions to predominantly clathrin - independent internalization processes is well recognized.
We hypothesized that certain lectins link glycosylated cargo proteins and glycosphingolipids into molecular nanoenvironments from which endocytic pits are formed without the help of the cytosolic clathrin machinery (Figure 1).
Johannes L, Parton RG, Bassereau P, Mayor S (2015) Building endocytic pits without clathrin.
In the Endocytic Trafficking and Intracellular Delivery team we study the cell biology of carbohydrate - binding proteins (lectins) at the level of cellular entry though clathrin - independent endocytosis, retrograde sorting on early endosomes, and translocation to the cytosol.
However, we have recently discovered that, depending on the concentration of ligand, the EGFR may also be internalised via an alternative clathrin - independent / lipid raft - dependent endocytic route: non-clathrin endocytosis (NCE)(4).
Cell surface receptors can be endocytosed by both clathrin - dependent and clathrin - independent mechanisms, but, as yet, there is no clear understanding of why alternative endocytic routes exist or how receptors are committed to a particular route.