Through a meticulous series of experiments, Tang homed in on one nutrient, a fatty acid called myristic acid, whose abundance, it turns out, worms can «monitor» using an enzyme called acyl -
CoA synthase 4 (ACS - 4).
Not exact matches
Abbreviations: LDLR = LDL receptor; APOB / A1 = apolipoprotein B - 100 / A1; PCSK9 = proprotein convertase subtilisin / kexin type 9; SREBP - 1 / 2 = sterol regulatory element - binding protein 1/2; LPL = lipoprotein lipase; FATP2 / 4/5 = fatty acid transporter protein 2 / 4/5; FASN = fatty acid
synthase; SCD5 = stearoyl -
CoA desaturase 5; ACADL = acyl -
CoA dehydrogenase; L - FABP = liver fatty acid - binding protein; and CPT1A = carnitine O - palmitoyltransferase 1.
The study also looked at «citrate
synthase (CS) and 3 - hydroxy -
CoA dehydrogenase (HAD)» activity in the vastus lateralis muscle.
(3) The researchers noted that the muscles of mice fed the MCTs produced higher levels of key metabolic enzymes (3 - oxo acid
CoA - transferase, citrate
synthase and malate dehydrogenase) involved in the Krebs cycle (tricarboxylic acid cycle), the body's primary energy production mechanism.
Tumor - bearing mice fed diets high in MCTs were found to have reduced levels of the enzyme fatty acid
synthase and also reduced acetyl
CoA, similar to tumor free mice, suggesting cancer cell metabolism was restored back to that of normal cells.94