Not exact matches
But it has been disappointing in that the kind of genetic variation it detects has
turned out to explain surprisingly little of the genetic links to most
diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk for
common diseases, based on researchers» discoveries...
The genetic analysis of
common disease is
turning out to be a lot more complex than expected.
The most
common cause of death in young children in developing countries is diarrhea (also a major fatal
disease in New York at the
turn of the century).
«It was assumed that
common variants might be responsible for
common diseases, but many
diseases turn out to have many different rare variants at their root,» says James Lupski, a medical geneticist at Baylor College of Medicine in Houston.
As Finnish geneticist Leena Peltonen wrote in a recent review, «The enthusiasm regarding the use of population isolates for the identification of predisposing genes for
common, polygenic
diseases has
turned to a silent drudgery.»
Tissue analysis has confirmed the diagnosis, but it
turns out that even this second patient didn't have a typical case of the
disease: Johann F. suffered from the less
common «plaque only» variant.
The long and winding journey to the roots of Alzheimer's
disease, the most
common form of dementia, has
turned up three new genetic clues — the first major ones in 15 years.
Of the dozen of these metabolites that were measured in cohorts from the longitudinal Framingham Heart Study (the long - term 1948 study to identify the
common contributive factors of cardiovascular
disease by following its development in a large subject group) levels of glycerol
turned out to be «significantly correlated» with resting heart rate, another indicator of fitness, as measured in the study.
With its uniquely comprehensive population data, deCODE is
turning research on the genetic causes of
common diseases into a growing range of products and services — in gene discovery, pharmaceuticals, DNA - based diagnostics, pharmacogenomics, in silico discovery tools, bioinformatics and medical decision support systems.
With its uniquely comprehensive population data, deCODE is
turning research on the genetic causes of
common diseases into a growing pipeline of products and services — in pharmaceuticals, gene and drug discovery, DNA - based diagnostics, pharmacogenomics, bioinformatics, and clinical trials.
Wheat is a good source of tryptophan, but when the wheat is contaminated with glyphosate, your gut cells go into overdrive and begin producing too much serotonin, which in
turn produces many of the
common symptoms of celiac
disease, such as diarrhea.
Tom O'Bryan discusses some
common environmental triggers that will «pull on the chain» in great detail, and how they lead to genes being
turned on and hence causing
disease: food quality, wheat, dairy sugar, glyphosate, plastic and air quality.
It only takes one popular sire to
turn a relatively infrequent
disease like CEA in Aussies into a
common one.
Because CKD is such a
common disease in cats, routine screening of all mature and older cats can help early diagnosis, which in
turn may prolong a good quality of life.
And not only is it
common, canine dental
disease can
turn into serious health problems later in life.
Most of the
common negligence cases that we see in dentistry are to do with periodontal
disease and lack of diagnosis and lack of treatments which has in
turn led to tooth loss and then the need to replace the teeth, usually with dental implants.