Not exact matches
Fluoxetine reduced depressive symptoms and
alcohol consumption in patients with
comorbid major depression and
alcohol dependence
51 patients between 18 and 65 years of age (mean age 35 y, 51 % men) diagnosed with current
comorbid major depressive disorder and
alcohol dependence using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised criteria.
The 44 % reduction in Ham - D - 24 scores between presentation and conclusion of detoxification and washout in this study is similar to that reported by Brown et al in patients with
comorbid primary
alcohol dependence and secondary depressive disorder.2 Thus, application of the results found by Cornelius et al to this clinical population may be appropriate.
To evaluate the effectiveness of fluoxetine in reducing depressive symptoms in patients with
comorbid major depression and
alcohol dependence.
Fluoxetine reduced depressive symptoms and
alcohol consumption in patients with
comorbid major depression and
alcohol dependence at 12 weeks.
This is the first double blind, placebo controlled study to show the effectiveness of a selective serotonergic drug in the reduction of depressive symptoms and
alcohol consumption in patients with
comorbid major depressive and
alcohol dependence disorders.