Sentences with phrase «cre expressing cells»

Not exact matches

Ng2 - Cre is known to be expressed in the male germline, which needs to be considered in using Ng2 - Cre mice for cell type - specific conditional mutagenesis experiments, but the germline expression of Pdgfrb - Cre in both sexes limits the use of Pdgfrb - Cre as deleter for pericyte - related experiments.

This feature facilitates screening of Cre - negative Brainbow mice to determine the number and type of cells in which the construct is expressed.

By injecting the modified viruses into transgenic mice that only express Cre recombinase in astrocytes, the researchers knew that any sequences flagged by the lox site inversion had successfully transferred their genetic cargo to the target cell type — here, astrocytes.

The DT40 cell clone used expresses an inducible form of the Cre recombinase (a MerCreMer fusion protein) in order to excise the floxed AID and thereby stop mutational activity if desired.