Sentences with phrase «current drug targets»

In a study published this year in Current Drug Targets, a combination of tocotrienols and quercetin induced senescence and promoted apoptosis in many different types of cancer cells, while delaying senescence in healthy cells and rejuvenating formerly healthy senescent cells.

McGeer EG, McGeer PL, Abeta immunotherapy and other methods of reducing amyloid, Current Drug Targets - CNS & Neurological Disorders 4:569 - 573, 2005 715.

As a result, this approach is severely under - exploited, despite the fact that the extensive human interactome presents opportunities that dwarf current drug targets.

Moreover, the binding with the MMP active site is discussed in the research paper, «Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors», published in Current Drug Targets.

In fact, a predominant number of current drugs target the GPCR signaling.

Not exact matches

The institute, which includes over 40 laboratories and more than 300 researchers, said the research would focus on modifying a patient's own immune system T - cells to target a tumor, studying ways to boost patient response to current immunotherapy drugs.

She said current drug laws disproportionately target people of color.

Wang points out that the current findings are preliminary and that comparing SLC13A5 activity in healthy and cancerous human liver tissue will be necessary before studies of this pathway as a cancer drug target should be contemplated.

In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carriers.

It also suggests the possibility of designing better sleeping pills by finding compounds that mimic adenosine's effects, says McCarley, who points out that current drugs do not target the adenosine receptors.

Researches are also testing drugs that target the VNN - 1 pathway to determine which, if any, might improve treatment for asthmatic children who do not respond to current treatments.

A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study.

«It can suppress many of the disease's signaling pathways, which current drugs on the market now try to target and treat.»

Learning why current anesthetics are so potent and sometimes dangerous will lead to a new generation of safer targeted drugs without unwanted side effects

«Current antiretroviral drugs target HIV's proteins,» says James Stivers, Ph.D., a professor of pharmacology and molecular sciences at the Johns Hopkins University School of Medicine, «but those proteins are moving targets because they are often altered by mutations.

Drugs that specifically target the persistent sodium ion flow, or current, have been approved by the Food and Drug Administration for treating epilepsy.

«Instead of targeting mGluR5, which is a very widespread molecule with many different functions, now we can target the persistent sodium current directly, using already approved drugs that are more specific and less likely to cause side effects,» Klyachko said.

«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»

Current antimalarial drugs are becoming less effective as the parasite develops resistance to the drugs, making the search for new targets that can kill all species of malaria critical.

«All current weight loss drugs control appetite, and there is nothing on the market that targets energy expenditure.

«Current therapies take advantage of this by using targeted drugs such as Trastuzumab or Lapatinib to specifically inhibit ERBB2, but eventually they become ineffective as the cancer develops resistance to those drugs.»

This is the first time that an Osmium - based compound — which is fifty times more active than the current cancer drug cisplatin — has been seen to target the disease.

This specificity could be valuable because current anti-influenza drugs target other parts of the virus, Jacob says.

Current drugs for metabolic diseases rely on hormones that are systemic throughout the entire body or drugs that target entire proteins.

-- In a blog post, Jay Bradner, the former head of Dana - Farber Cancer Institute and the current president of Novartis Institutes for Biomedical Research, wrote that too many investment dollars have gone into redundant cancer programs, such as more checkpoint inhibitors, rather than going after tougher drug targets that might have a greater future impact.

Illustrating the tricky path current Alzheimer's research faces, the study was published literally hours after giant pharmaceutical company Merck announced the cancellation of a Phase 3 clinical trial surrounding a drug that targets the exact same enzyme.

Caribou is advancing its CRISPR - Cas9 platform in drug target screening and validation to help overcome the limitations of current RNAi - based approaches.

Erinna says that based on current results, the researchers now believe that a drug targeting BFL - 1 could be highly effective for treatment of melanoma, particularly if used in combination with the currently available MCL -1-targeting molecule.

Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.

80 percent of all current drugs affect membrane proteins, and more than 50 percent of all drugs target them directly.

Current melanoma drugs targeting single proteins can initially be effective, but resistance develops relatively quickly and the disease recurs.

Acetylcholine receptor, which is the target of drugs (nicotine, ethanol) and current therapeutics (anaesthetics, anxiolytics, anti-smoking and anti-Alzheimer's).

However, for the majority targeted therapies in development — and their combinations with current standard therapies — there are still no approved diagnostic tools to determine which patients are most likely to benefit from or be resistant to these novel agents or drug combinations.

In contrast to the current drugs that target one protein or one mechanism, microRNA - based AMD therapy provides a unique «one - molecule, multiple - targets» model for disease treatment, which fits particularly well with the complex nature of AMD.

ORIC Pharmaceuticals, Inc. is a small molecule oncology company focused on combating the growing resistance problem to current molecularly targeted drugs.

ORIC is a small molecule oncology company focused on combating the growing resistance problem to current molecularly targeted drugs.

His current research focuses on chemical evolution of sequence - defined carriers for drugs, proteins and therapeutic nucleic acids, with a medical focus on tumor - targeted therapies.

«The task was to find the rogue proteins in cancer and go after them and spare the normal cells,» says Buolomwini, who later founded the journal Current Cancer Drug Targets to chronicle the field.

The findings could lead to improved effectiveness of current treatments for IBD, as well as the discovery of new drug targets, the study authors said.

A drug which targets insulin signalling appears to restore insulin sensitivity in mice Type 2 diabetes is a massive burden on healthcare systems around the world, and while current treatments are able to manage many aspects of the condition, they are not curative.

You'll see similar ones about «curing cancer» when they've identified a new protein that MIGHT be a drug target, against which drugs MIGHT be developed, which MIGHT or MIGHT NOT be better than current drugs and which will only come to market in 15 years.