Cyclooxygenase produces of a number of different compounds known as prostanoids (prostaglandins, prostacyclin and thromboxanes).
Not exact matches
Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) relieve pain and inflammation by blocking either or both of the
cyclooxygenase (COX) enzymes, which
produce pro-inflammatory prostaglandins.
As I illustrated above, arachidonic acid is processed by the enzyme
cyclooxygenase (COX) to
produce pro-inflammatory signaling molecules called eicosanoids, including leukotrienes, prostaglandins, and thromboxanes.
'' [NSAIDs] are strong inhibitors of the enzyme
cyclooxygenase — COX — which is an important enzyme that is responsible for
producing inflammatory mediators,» Etminan says.
In the case of
cyclooxygenase (COX), it stimulates cells to
produce several substances, including prostaglandins, after the cells are damaged.
By inhibiting
cyclooxygenase, thromboxane can not be
produced and the platelets present at the time aspirin is given are permanently inactivated.
If the enzyme
cyclooxygenase 1 (COX 1) transforms arachadonic acid, PG E1 prostaglandin is
produced.
Ibuprofen is what is called a non-selective
cyclooxygenase inhibitor, which means it inhibits all types of
cyclooxygenase, not just the ones that
produce inflammatory mediators.
As mentioned, inflammation is mediated by prostaglandins (
produced by
cyclooxygenase) and leukotrienes (
produced by 5 - lipoxygenase).