Sentences with phrase «cytokines signaling through»

In essence, cytokine signalling through TYK2 for those carrying genetic markers for autoimmune diseases is low enough to protect against autoimmunity, but high enough to prevent immunodeficiency.

Not exact matches

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors.

Cytokines can reach the brain several ways: directly through the blood - brain barrier or indirectly by binding to nerve fibers elsewhere, which send signals to the brain to produce the inflammation molecules.

«This study has opened the field of research into using EGCG for targeting TAK1 — an important signaling protein — through which proinflammatory cytokines transmit their signals to cause inflammation and tissue destruction in rheumatoid arthritis,» said Ahmed.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Senescent fibroblasts secreted oxidized HMGB1, which stimulated cytokine secretion through TLR - 4 signaling.

Signaling through the CXCR3 - mediated, MyD88 - dependent pathway generates a Th1 - dominant, pro-inflammatory cytokine milieu that recruits mononuclear cells into the submucosa (Fasano, 2011).

In the opposite situation, when a healthy immune system reacts to environmental factors through cytokine production, PRPs send signals via specific cell receptor sites to decrease the production of cytokines in order to balance the immune system.

Citing again from the study previously mentioned titled Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll - Like Receptor - 4 and Suppressor of Cytokine Signaling - 3 «Thus, saturated fats may have a more profound role in the pathogenesis of postprandial inflammation, as they may also perpetuate inflammation through the increases in LPS and TLR - 4.»