"Cytotoxic chemotherapy" refers to a type of treatment that uses strong drugs to destroy cancer cells in the body. These drugs are designed to kill rapidly dividing cells, including cancer cells. The goal of
cytotoxic chemotherapy is to stop or slow the growth of cancer, prevent it from spreading, and potentially cure the disease.
Full definition
This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or
conventional cytotoxic chemotherapy beforehand.
Given the aggressive nature of BPDCN and the need
for cytotoxic chemotherapy the patient elected to terminate her pregnancy which was a difficult emotional decision for her and her spouse to make.
Approximately one year after successful treatment
with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.
This trial involved patients who had not previously been exposed to
cytotoxic chemotherapy, but its conclusions were similar to those of the first.
«
The cytotoxic chemotherapy can first kill some cancer cells and enhance the sensitivity of the tumour toward ICB therapy, which then stimulates the effectiveness of the ICB therapy,» said co-author Gianpietro Dotti, PhD, professor of microbiology and immunology at the UNC School of Medicine and member of the UNC Lineberger Comprehensive Cancer Center.