Sentences with phrase «d microenvironment»
«I think that we've produced a 3 - D microenvironment which is much more like that found in vivo for growing embryoid body, which explains the higher levels of cell proliferation.»
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Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.
But until now, scientists have been hard - pressed to develop new therapies for treating IBDs due to their inability to replicate the human gut microenvironment in the laboratory.
«These occult lung cancer cells have found a unique way to co-opt the «brain microenvironment» and survive,» said Nguyen.
The importance of exosomes in the tumour microenvironment has been demonstrated within the field in recent years, as it has been shown that tumour development is halted if the production of exosomes inside the cancer cell is stopped.
University of Illinois researchers have developed a new technique to create a cell habitat of squishy fluids, called hydrogels, which can realistically and quickly recreate microenvironments found across biology.
I think they may have been missing a piece of the puzzle, by not considering aging and the tumor microenvironment.»
This study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.
Down syndrome is caused by having three copies of chromosome 21 instead of two, and since four of the six interferon receptors — the proteins that sense the presence of interferons — are encoded on chromosome 21, cells with trisomy 21 react more strongly to small amounts of interferons in their microenvironment.
Studies in recent years by Beatty's laboratory and others have pointed to one potential source of this treatment resistance: Pancreatic tumors tend to surround themselves with a protective «microenvironment.»
To date, much of the research on irradiation's effects on the cellular microenvironment has dealt with samples that included cells, obfuscating the irradiation's effect on just the ECM rather than the cell's internal machinery.
In these leaves, Azolla have created a microenvironment, co-evolving with tiny bacteria called cyanobacteria for an estimated 100 million years.
«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.
When looking for culprits, researchers have often focused their microscopes on macrophages, which occupy a meaningful spot among the white blood cells in the tumor microenvironment.
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified the microenvironment surrounding microvasculature — the small blood vessels that transport blood within tissues — as a niche where dormant cancer cells reside.
«If we want to understand the role of estrogen, we now have to look at how the tumor and the microenvironment communicate with one another,» den Boon says.
The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).
Protecting this microenvironment, or niche, has thus emerged as a new route for the treatment of these diseases, for which there is currently no fully effective treatment.
«With Teresa Woodruff's research using Draper's human organ system platform, we have a compelling demonstration of the importance of a microenvironment that permits cells to function in vitro as they would in vivo, and the power of being able to interconnect organ models on a platform and operate them in a stable and precise manner for weeks to months,» said Jeffrey T. Borenstein, a biomedical engineer at Draper.
The fact that FOX01 behaves in this unexpected way could have to do with the specialized microenvironment of a cell in a wound, Graves noted.
In the future, this system will be further developed to reconstruct microenvironments of stem cells outside a living body, which would aid studies on stem cells for regenerative medicine.
Basic research has centered on identifying and characterizing hematopoietic stem cells, however, it is still not clear how hematopoietic stem cells actually work, and how they are regulated because of the complexity of the bone marrow microenvironment.
Zebrafish provide a similar tumour microenvironment to humans, meaning fewer tests need to be carried out in mice and any future experiments in mice will have been optimised to have minimal toxicity.
They have to be in the right microenvironment.»
«Our research has identified the right soil for seeds to flourish by looking at the microenvironment in the breast and examining the mechanisms at play.
Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment.
For about a decade, researchers have been able to direct the fate of stem cells by tuning the stiffness of its microenvironment.
The team has been able to prove that such epigenetic alterations are associated with the increased levels of an enzyme, namely DNA methyltransferase 3A (DNMT3A), which is responsible for the acquisition of the suppressive properties of these cells that develop in the tumoral microenvironment.
Presumably, a scaffold provides some sort of microenvironment — a niche that allows a cell to adopt the normal 3D morphology that it would have in the body.
Now, Salk scientists have pinned down how signals from this microenvironment encourage pancreatic tumors to grow by altering their metabolism.
According to the study's results, the microenvironment of a tumor cell has significant impact on cancer metastasis.
«The microenvironment has tremendous impact on how the gene is expressed, what type of gene will be expressed.
This discovery by Siyuan Zhang at the University of Notre Dame and a team at the University of Texas MD Anderson Cancer Center has focused attention on fighting cancer in the tumor cell's microenvironment.
Zhang, the Nancy Dee Professor of Cancer Research, has published the breakthrough, «Microenvironment - induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth,» this month in Nature.
«You have more stem cells and they're able to operate independent of inputs coming from their microenvironment,» Yilmaz says.
On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.
Although this benefit has not been seen in all patients treated with immunotherapy, one of the goals of the CCIR is to improve our understanding of the immune system, especially in the context of the tumor immune microenvironment, in order to modulate immunity to optimally enhance patient outcome.
Normal wound healing shares many similarities with the tumor microenvironment, and indeed tumor invasion has been compared to «wound healing gone awry.»
Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.
«Altered microenvironment promotes progression of pre-invasive breast cancer: myoepithelial expression of integrin DCIS identifies high - risk patients and predicts recurrence» by Michael D Allen et al. published in Clinical Cancer Research on Tuesday 3 December.
We have shown that invariant Natural Killer T cells (iNKT), a subset of CD1d - restricted T cells displaying innate effector functions, rewire the prostate cancer microenvironment leading to cancer control.
In both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyfts.
We have developed pre-clinical models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to specific organs such as the liver, lungs and brain.
Recently, there has been progress in the treatment of patients with malignancy through targeting receptors on the surface of CD8 + T cells that inhibit their activity within the highly suppressive tumor microenvironment.
In the short - term, this functional interplay would allow injured cells to restore damaged DNA templates or communicate their compromised state to the microenvironment.
iTeos has developed an innovative in vitro phenotyping screening assay that mimics the tumor microenvironment.
It is important to understand changes in this microenvironment, because it might have consequences for air - sea interactions that are relevant for our climate.»
However these compounds were designed as competitive antagonists to be active in the brain of patients having low concentration of adenosine whereas high levels adenosine are produced by ectonucleotidases, especially CD73 and CD39 that are overexpressed in the tumor microenvironment.
Dr. Sadelain's work has focused on developing novel strategies to extend survival of CAR T cells in the body and enable T cells with increased potency to overcome the resistance imposed by tumor and other cells in the tumor microenvironment.