Sentences with phrase «ddx3 on cell growth»

The runaway replication of cancer cells can also traced to genetic causes — mutations that remove the normal controls on cell growth.

Thus, the molecule's observed «effect» on cell growth is nothing more than the well - known cytotoxic effect of alcohol.

The graph's caption claims that it shows a «dose - dependent» effect on cell growth — the paper's linchpin result — but the data clearly show the opposite.

For subsequent experiments we used an MOI of 600 as this provided near - maximal disruption efficiency with limited impact on cell growth.

Thus, treatment with X4 - ZFNs of both wild - type and ccr5Δ32 CD4 + T cells confers stable cxcr4 disruption and a marked survival advantage in the presence of R5X4 - HIV and X4 - HIV in vitro without any detectable effect on cell growth or viability in the absence of HIV.

Differential interference of chlorpromazine with the membrane interactions of oncogenic K - Ras and its effects on cell growth.

To explore the biological function of DDX3 on cell growth control, a colony formation assay was done in several tumor cell lines (HuH - 7, HCT116, and HeLa) and normal murine fibroblast cells (NIH 3T3) under the selection of G418.

The automated cell culturing and analysis system provides an optimal tool for the evaluation of hESC cultures, allowing continuous well - to - well comparison of the effects of different culture media or different growth factor concentrations on cell growth and behaviour — such as differentiation.

In contrast, in five luminal breast cell lines, MELK knockdown with equivalent efficiency did not result in obvious inhibition on cell growth (Figure 5E, Figure 5 — figure supplement 1A, B).

-- Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells

In summary, perhaps through glucose «starvation» of tumour cells and by reducing the effect of direct insulin - related actions on cell growth, ketogenic diets show promise as an aid in at least some kind of cancer therapy and is deserving of further and deeper investigation — certainly the evidence justifies setting up clinical trials.

Her $ 28 Acne Skin Care Set offers a threeway of zit - zapping solutions — a face wash made with olive and coconut oils, French green clay, green tea, aloe vera, and tea tree oil; a toner comprising organic lavender hydrosol water, aloe vera, and witch hazel; and a chamomile - and Shea butter - based night cream with grapeseed and safflower oils to spur on cell growth and accelerate healing.

Not exact matches

Meanwhile, Techcrunch notes that although mobile subscriber growth in China is actually slowing — since most people have cell phones — the percentage of people who can connect to the Internet on their phones is accelerating rapidly.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

As a cancer researcher, do you think the mechanisms of tumor growth are somehow changing to come into line with your perceptions, or is it possible that the process of our learning more about DNA mutations and cell architecture and nutrient exchange and epigenetic effects make it possible for us to inch ever closer to understanding that which is already going on under our noses?

The cells in my index finger are quite limited in terms of what they may achieve on their own, for their individual activity is restricted to processes of growth, oxygen exchange, homeostatic adjustment, and the like.

Hindmilk, on the other hand, is the creamy milk with higher fat content that is stored in the milk - making cells located higher up in the breast, and helps stimulate your baby's growth.

One such protein, EGF, was already high on the list of suspects due to its abundant presence in breast milk and its well - known role in promoting the growth and development of cells in various tissues.

Although these spots themselves are harmless, if some of the spots are bigger than a 50 cent coin, then it could be due to Neurofibromatosis (NF), which is a genetic disorder of the nervous system that causes abnormal cell growth of nerve tissues or benign tumours to form on the nerves anywhere in the body at any time.

They're harmless, but do keep an eye on the size and quantity of these spots, since having six or more that are larger than a quarter may be a sign of neurofibromatosis (a genetic disorder that causes abnormal cell growth of the nerve tissue).

The best explanation so far, says Henrietta van Praag, a neurobiologist at the National Institute on Aging, is that exercising the heart somehow stimulates growth factors to produce new nerve cells in the brain.

BOX 26, B -3-3; 30215360 / 734836 SAPA Reading Excerises, Activity of Rats, 1973 - 1974 Auto - Instructional, Point - to - Point, 1973 - 1974 Reading Excercises, Left Hand - Right Hand, 1974 Interpreting Data, Earth Maps and Mars Photos, 1974 Interpreting Data, Earth Maps and Mars Photos, 1974 Experimenting, I See, I See, 1974 Experimenting, Pressure and Volume, 1974 Operational Definitions, Flowers, 1974 Interpreting Data, Scientific Notation, 1974 Formulating Hypothesis, Optical Illusions, 1974 Experimenting, Interference in Learning, 1974 Experimenting, Density, 1974 Experimenting, Plants in Light, 1974 Interpreting Data, Things Look Bigger (Cells), 1974 Classifying, Six Legged Wonders, 1974 Experimenting, The Influence of Light on Plant Growth, 1974 Measure I & II, Testing Guides and Tests General Evaluation Questionnaire (4 Folders), 1971 - 1972

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Low - power laser light shined on damaged rat teeth activates growth factors that cue stem cells to generate the tooth constituent dentin, leading to regeneration.

While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles on a detour route, make use of additional pathways to continue growing and spreading.

As might be expected of an autoimmune disease, where the immune system turns on healthy tissue, all the genes play a role in controlling the growth and multiplication of cells in the immune system.

One of the team's new biosensors is made from a nanoplasmonic material that is able to accommodate a large number of cells on a single substrate and to monitor cell proliferation, a fundamental process involving cell growth and division, in real time.

Living cells are micrometer - scale units capable of replication, growth, chemical synthesis, and movement using technologies operating on individual molecules at the nanometer scale.

Only cancer cells that received these growth factors switched on this pathway, and only they could seed new tumours when injected into mice.

Investigators focused on the tumor suppressor liver kinase B1 (LKB1), a protein that controls cell growth and metabolism.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

Erbitux binds to and inhibits a growth - promoting protein on cancer cells.

Not only the root's stem - cell niche is located there, the root tip also accommodates sensors for an auxin - dependent growth of the plant based on gravitation.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

This mutation is on a particular receptor, or docking site, on the cancer cells that is crucial to the cell's growth and survival.

Because of the strong association between hippocampal cell growth and exercise in models, previous work on exercise and the brain has not focused on the entorhinal cortex, despite its critical role in learning and memory until now.

The researchers observed the effect of the synthetically produced molecule, JK - 31, on the growth and proliferation of a model human breast cancer cell line and found that it effectively blocked the protein cyclin - dependent kinase 1 (CDK1), which plays a key part in the process of the division of cancer cells, and therefore inhibited the proliferation of the cells.

To do so they focused on keratinocytes, a specific type of skin cells with a key role in psoriasis because of their abnormal growth and ability to produce large amounts of inflammation promoting factors.

Patients received a tandem of lenalidomide, a drug that kills tumor cells, blocks blood vessel growth, and acts on the immune system, and dexamethasone, an anti-inflammatory agent, plus one of three new agents:

«CRKII most likely regulates the stability of mutated epidermal growth factor receptors and drives cancer growth by promoting signaling, or communication, within cancer cells,» said Julia Petschnigg, lead author on the paper and a postdoctoral fellow at U of T. «We found that a combinatorial chemotherapy that inhibits those mutated receptors and CRKII could be beneficial in treating lung cancer.»

«Let them eat xylose: Yeast engineered to grow efficiently on novel nutrients: Discoveries may lead to faster growth and higher cell densities in biological engineering applications.»

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

«We also know that this RhoB pathway, once turned on, can stimulate the expression of two proteins: p21, which prevents cells from replicating, and BIM, which induces cell death — both of which can help stop cancer growth.»

The team's further experiments on cultured heart cells confirmed that GDF - 11 stops the thickening growth seen with age.

Simultaneously, the research team in CRAG led by Ana Caño Delgado discovered more details on the root growth and its post-damaged cell repair capacity, which have been published in the Journal of Cell Sciecell repair capacity, which have been published in the Journal of Cell ScieCell Science.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostinis.

Hayashi then drew on other research showing that one key regulatory molecule (activin A) and a growth factor (basic fibroblast growth factor) could convert cultured early embryonic stem cells into cells akin to epiblasts.

There are several factors that may affect the growth of stem cells based on batch - to - batch media variation,» said Alysson Muotri, PhD, associate professor in the UC San Diego departments of Pediatrics and Cellular and Molecular Medicine.

By comparing proteomic and RNA - sequencing data from people on different exercise programs, the researchers found evidence that exercise encourages the cell to make more RNA copies of genes coding for mitochondrial proteins and proteins responsible for muscle growth.

The study builds on previous findings suggesting that AIM2 limits cancer cell growth in colon cancer cell lines, Wilson said, as well as on a clinical report of poor prognosis in colon cancer patients with low or missing AIM2 levels.