The basic idea of DNA origami is to use a length of single - stranded
DNA as a scaffold for the desired shape.
Not exact matches
Researchers at McGill University have developed a new, low - cost method to build
DNA nanotubes block by block — a breakthrough that could help pave the way for
scaffolds made from
DNA strands to be used in applications such
as optical and electronic devices or smart drug - delivery systems.
Histones are proteins that serve
as a
scaffold for coiling up the
DNA into the tight space of the nucleus.
The order of bases in each short strand acts
as a blueprint that dictates the
scaffold DNA's final, 3 - D shape.
He wants to exploit
DNA's unique chemical properties to process information like a computer (using novel scientific disciplines known
as molecular programming and
DNA computing) and even appropriate the
DNA molecule
as a
scaffold on which to build useful structures.
«We're using precisely shaped
DNA constructs made
as a
scaffold and single - stranded
DNA tethers
as a programmable glue that matches up particles according to the pairing mechanism of the genetic code — A binds with T, G binds with C,» said Wenyan Liu of the CFN, the lead author on the paper.
We have known for some time that it's not only the sequence of the
DNA that is important; the physical
scaffold, organization, and regulation of the
DNA is also key and is known
as epigenetics.
The folded
DNA then acts
as a
scaffold onto which researchers can attach and organize all kinds of nanometer - scale components, from fluorescent molecules to electrically conductive carbon nanotubes to drugs.
At various points in this process, cells use RNA
as a sort of
scaffold to help replicate
DNA.
A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a single point mutation in the gene encoding lamin A, which forms a protein
scaffold on the inner edge of the nucleus that helps maintain chromatin structure and organize nuclear processes such
as RNA and
DNA synthesis.
As smaller genomic
scaffolds tend to be over-represented by
DNA from environmental sources (DW unpublished observation) we also conservatively excluded any candidate region that was located in a
scaffold smaller than 5 Kb in length.