Sentences with phrase «dna damage involving»

Not exact matches

Other proteins such as histones are involved in the packaging of DNA or repairing the damage to DNA that causes mutations.

Ageing is a complicated process, involving DNA damage, chronic inflammation, and worn - out cells, but we don't yet know which of these has the biggest impact on ageing.

Zinc is a particularly versatile player, involved in more than 300 enzymatic reactions; when zinc goes missing, a cell's DNA and its repair machinery can be damaged.

NER involves several steps — the first is to recognise when one strand of a double - helix DNA molecule is damaged.

«Oxygen by - products produced during normal metabolism can cause oxidative damage to biomolecules in cells, such as DNA and RNA,» explains Jian - Ping Cai, a researcher involved in the study.

Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.

Using these mice, the researchers will be able to further refine the detailed mechanisms involved in the repair of DNA damage.

PARP (Poly ADP - Ribose Polymerase) inhibitors, such as olaparib, are targeted drugs that block an enzyme involved in many functions in the cell, including the repair of DNA damage.

We thus envisage the molecular mechanism of interallelic complementation to involve the exchange of XPD molecules within the TFIIH complex or turnover of TFIIH complexes containing different XPD molecules at the site of DNA damage during the course of the global genome as well as transcription - coupled repair of either UV - induced or endogenous DNA damage.

Oscar Fernandez - Capetillo, Karolinska Institutet / SciLifeLab, and colleagues, have explored how mammalian cells might become resistant to chemical inhibitors of ATR, a molecule involved in sensing DNA damage.

Genes known as BRCA1 and BRCA2 are involved in cell growth and the repair of damage to DNA.

Elephants have 20 copies of the gene p53, a tumor suppressor famous for being involved in apoptosis or «assisted suicide» for cells with damaged DNA, for example.

These off - target effects may actually be beneficial in treating IBD, primary sclerosing cholangitis, primary sclerosing cholangitis / IBD - related CRC, and asthma, whereby a multitude of abnormal signaling involving inflammation, oxidative damage, DNA damage, and apoptotic abnormalities exists to manifest itself into a diseased state.

The mutation damages the regulation of DNA in cells involved in the cancer — a form of epigenetic change.

Genes involved in DNA damage control and inhibition of DNA synthesis [49], in particular Atm, Chk1 and Chk2, are also highly expressed in ES cells, but decline during differentiation.

p53 not only down regulates cell division during the normal process of aging and senescence, but it is also involved in a response to DNA damage [27,28] and telomere shortening [29].

From the perspective of aging, DNA damage more and more seems to reflect the accumulating harm being done to the enzymes and enzyme systems involved in sensing and regulating the energy supply.

To determine whether or not the damaging effects on cancer cells would affect normal cells — which are already programmed normally for apoptosis — they doused both cancerous liver cells and normal liver cells with CVE to examine the process of inducing apoptosis, which involves creating DNA damage as a precursor.

A vicious cycle exists in which molecular mechanisms involved in the aging process, such as oxidative stress, DNA damage, senescence, and inflammation, lead to tissue NAD decline which subsequently exacerbates the processes that caused its decline in the first place.

When regions of the E. coli genome known to be involved in DNA damage were removed, the ability of the E. coli to cause tumors was substantially decreased.

Singlet oxygen has been implicated in biological systems and is capable of damaging proteins, lipids and DNA and therefore is thought to be involved in the pathogenesis of numerous diseases.

Selenium is a trace mineral involved in maintaining reproductive health, metabolizing thyroid hormones, synthesizing DNA, and protecting the body from free radical damage and infection.

Zejula is designed to block an enzyme involved in repairing damaged DNA.