Sentences with phrase «dna damage is the cause»

Not exact matches

Researchers found that all varieties had protective properties, with the outer layers of the red variety being a particularly rich source of quercetin, and showing significant protection of DNA damage caused by free radicals.

One of the primary causes of cancer is the accumulation of DNA damage by free radicals.

But the chemical has since 1995 been ruled as unsafe in food for human consumption because it is capable of causing damage to one's DNA which can potentially lead to the formation of malignant tumours.

On one end is a DNA catcher that can cause some serious damage when you use the right grip and amount of force.

Reactive oxygen species, also called free radicals, are chemicals that typically contain oxygen, are known to be found in cigarette smoke, and cause DNA damage in cells.

Other proteins such as histones are involved in the packaging of DNA or repairing the damage to DNA that causes mutations.

The Lymphocyte Genome Sensitivity (LGS) test looks at white blood cells and measures the damage caused to their DNA when subjected to different intensities of ultraviolet light (UVA), which is known to damage DNA.

Many scientists believe that the aging process is caused by the gradual buildup of a huge number of individually tiny faults — some damage to a DNA strand here, a deranged protein molecule there, and so on.

Perhaps the sole point on which scientists agree is that radiation damages DNA in ways that can cause cancer many years after exposure.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

Washington State University researchers have mapped the damage of ultraviolet radiation on individual units of DNA, opening a new avenue in the search for how sunlight causes skin cancer and what might be done to prevent it.

This group determined that the cause was that the function of the Tel1 protein, which is important for DNA damage response, was not fully implemented in xrs2 mutations.

Our body has a system to repair DNA damage (DNA repair mechanism), so why a normal cell turns into a cancer cell and why radiation exposure causes cancer have not been clarified.

There is currently no evidence that dioxin damages DNA and so causes mutations.

Conventional risk models used by NASA and others assume DNA damage and mutation are the cause of radiation cancers.

The idea that Romesberg came up with was to block one of the molecular processes that the bacterium goes through to prevent the drug from binding to it and causing this havoc of damage to its DNA and one of the ways that that resistance develops.

Sunburn in living organisms is caused by ultraviolet (UV) light from the sun damaging the DNA in the cells.

Mutagens are chemicals that can cause DNA damage in cells that in turn can cause cancer.

The scientists from Berlin now found that while DNA damage induced by other means, such as irradiation or genotoxic chemicals, is indeed random, the damage caused by H. pylori is not.

Prof. Umeda found that inhibiting CDKs even with the absence of DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.

Further, the risks associated with radiation were even higher for survivors who also received the alkylating agent procarbazine, a type of chemotherapy known to cause damage to DNA.

Beyond repair and replication processes, ribonucleotides can also be created in DNA as a result of damage caused by drugs, environmental stressors and other factors.

The test is increasingly used as a method of assessing substances — including drugs and cosmetics — that could pose a potential risk to human or environmental health by causing damage to DNA.

Groups at Rockefeller and elsewhere are trying to understand how AID causes its off - target damage to DNA, which could lead to new treatments.

Silver says her lab will try to build such a cell that they can then implant into mammals to detect and report on the extent of harm caused by UV radiation, which damages DNA and is a risk factor in the development of cancer.

Fanconi is caused by any one of eight defects in human chromosomes, six of which had been pinpointed to proteins that flock together to help repair damaged DNA.

Anthracycline drugs, such as doxorubicin, are known to cause heart failure because they cause changes in the DNA structure of the heart muscle cells, leading to irreversible cardiac damage.

Biophysicist Richard Setlow of the Brookhaven National Laboratory in Upton, New York, says the findings are interesting because they show that the DNA damage causes the immunosuppression in sunburn, but that this damage is reversible.

As part of the international EU project «SPICE II Plus,» which is now coming to an end, scientists from the MedUni Vienna's Institute for Cancer Research have now also found evidence that synthetic substances damage the DNA of human cells and can therefore possibly have cancer - causing effects.

Together, Escherichia coli and Bacteroides fragilis cause DNA damage that could lead to cancer - causing mutations, although this hasn't been seen in people yet.

A-T is caused by lost function in a gene, ATM, which normally repairs damaged DNA in the cells and preserves normal function.

One possibility, says Chao, is that high numbers of CNVs somehow cause DNA damage by making dads less able to protect themselves from environmental insults such as radiation.

There are various causes of senescence: Damage to the DNA is just as possible as is the attainment of a maximum number of divisions (limited by the so - called telomeres).

In the course of comparing P. destructans to six closely related non-pathogenic fungi, researchers discovered that P. destructans is unable to repair DNA damage caused by UV light, which could lead to novel treatments for the disease.

This is because faults in the gene mean the cell can not properly repair its DNA, causing genetic damage to build up, leading to cancer.

Biologists have generally assumed that the damage will be proportional to the dose, but in vitro studies have shown that cells can repair modest DNA damage caused by radiation — and that low - dose radiation might even protect the cell against future exposure.

Melanoma is associated with DNA damage and genomic alterations caused by ultraviolet light.

The goal of gene therapy is to replace damaged genes with ones that work to address a root cause of cancer: damage to DNA.

The next phase of Gianneschi's research will look at how these synthetic melanin nanoparticles can be used in practical applications to protect against DNA damage caused by the sun's UV rays.

Similar results were obtained by electrochemical voltammetric in situ detection of DNA oxidative damage caused by the reduced anthracycline doxorubicin, a classical chemotherapeutic which intercalates into DNA [81].

Inhibition of ROS induced by reflux may be a useful strategy for preventing DNA damage and decreasing the risk for tumor formation caused by GERD, they concluded.

New research by scientists shows that when cellular barriers are exposed to metal nanoparticles, cellular messengers are released that may cause damage to the DNA of developing brain cells.

The damage that it will repair is the one that is causal in senenscence of DNA pathway (such x-ray radiation causing senescence) and oncogenic activated senescence; but not of the type of replicative senescence (that's the domain of telomeres / telomerase / sub-telomeres and epigenetics) and cellular replication / proliferation.

Despite the protection offered by the cellular environment, the integrity of DNA is continuously challenged by a variety of endogenous and exogenous agents (e.g. ultraviolet light, cigarette smoke, environmental pollution, oxidative damage, etc...) that cause DNA lesions, interfering with proper cellular functions, such as transcription, inducing premature cellular death and finally premature ageing and organs dysfunctions.

Inside neurons, ATM provides a crucial role in repairing the cell's infrastructure, somewhat like that of a bridge inspector, but the expanded HD protein may be causing ATM to misjudge DNA damage.

Dr. Bishop is a molecular geneticist whose research focuses on DNA damage responses and the resultant genomic instability, a fundamental cause of cancer.

DNA is constantly exposed to a variety of damaging factors such as genotoxic agents, environmental factors (e.g. UV light, irradiation) or normal metabolic activities (e.g. nucleotide misincorporation during DNA replication, reactive oxygen species) that causes a range of lesions.

The accuracy of next - generation sequencing (NGS) for detecting tumor - specific mutations in plasma DNA is hindered by errors introduced during PCR / sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency.

A high dose of ActD has been reported to cause DNA damage and suppress transcription from all three classes of RNA polymerases, and ActD at a low dose has been reported to selectively block RNA poly I - dependent transcription [19].

Radiation is known to damage DNA and cause chromosomal instability.