Sentences with phrase «dna damage sites»

Not exact matches

Tilivalline itself lacks the DNA - damaging activity of its antitumor antibiotic relatives because the chemical site crucial for DNA interference is blocked.

The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return — treatment failure.

«It also allows mapping rNMPs even in conditions in which the DNA is exposed to environmental stressors that damage the DNA by generating breaks and / or abasic sites.»

Now, the California Institute of Technology chemist is amassing evidence that cells harness this ability to help them home in on sites of DNA damage within each cell by revealing defects in DNA that disrupt its charge - carrying ability.

This binding site is occupied in case of nucleotide misincorporation in the RNA or damage to the DNA, and is termed the «P» site because it supports proofreading.

When DNA damage occurs in these cells, the GFP lights up at the site of the repairs.

Although its raison d'être remains elusive, the gene appears to play an important role in DNA repair: Mice lacking the protein Brca1 have trouble fixing DNA damage induced by radiation, for instance, and the protein clumps in the nucleus at sites where DNA is broken.

When such DNA damage occurs, proteins known as PARPs move to the site of damage and begin to mend these broken strands of DNA, allowing cancerous cells and tumors to recover, grow and proliferate, thereby escaping the effects of treatment.

We thus envisage the molecular mechanism of interallelic complementation to involve the exchange of XPD molecules within the TFIIH complex or turnover of TFIIH complexes containing different XPD molecules at the site of DNA damage during the course of the global genome as well as transcription - coupled repair of either UV - induced or endogenous DNA damage.

53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

Guo R, Chen J, Zhu F, Biswas AK, Berton TR, Mitchell DL, Johnson DG (2010) E2F1 localizes to sites of UV - induced DNA damage to enhance nucleotide excision repair.

In the presence of DNA damage, the macro domain of ALC1 is bound to PAR chains that accumulate at the damage site.

Telomeres are repetitive DNA sequences that protect the end of the chromosome from being recognized as sites of DNA damage.

Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.

At sites of UV damage, E2F1 recruits the histone acetyltransferase GCN5, which acetylates histone H3K9 in order to open chromatin structure and increase accessibility to the damaged site by the DNA repair machinery.

It has recently been described that Xpa is essential to recruit endonucleases and polymerases to the damage sites to restore the original DNA sequence [27].

Abasic sites are where the DNA has molecular damage.