Prof. Umeda found that inhibiting CDKs even with the absence of
DNA damage would cause the Rep - MYB3R accumulation seen with DNA damage and stall the cell cycle before the M phase transition.
Not exact matches
Researchers found that all varieties
had protective properties, with the outer layers of the red variety being a particularly rich source of quercetin, and showing significant protection of
DNA damage caused by free radicals.
But the chemical
has since 1995 been ruled as unsafe in food for human consumption because it is capable of
causing damage to one's
DNA which can potentially lead to the formation of malignant tumours.
Washington State University researchers
have mapped the
damage of ultraviolet radiation on individual units of
DNA, opening a new avenue in the search for how sunlight
causes skin cancer and what might be done to prevent it.
Our body
has a system to repair
DNA damage (
DNA repair mechanism), so why a normal cell turns into a cancer cell and why radiation exposure
causes cancer
have not been clarified.
«Most antibiotics
have their effect, directly or indirectly, by
causing damage to bacterial
DNA, so finding ways to cripple
DNA repair
would represent a significant advance in the treatment of resistant infections,» says senior study author Evgeny Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology, NYU Langone.
Fanconi is
caused by any one of eight defects in human chromosomes, six of which
had been pinpointed to proteins that flock together to help repair
damaged DNA.
As part of the international EU project «SPICE II Plus,» which is now coming to an end, scientists from the MedUni Vienna's Institute for Cancer Research
have now also found evidence that synthetic substances
damage the
DNA of human cells and can therefore possibly
have cancer -
causing effects.
Together, Escherichia coli and Bacteroides fragilis
cause DNA damage that could lead to cancer -
causing mutations, although this hasn't been seen in people yet.
Previous research
has suggested that alcohol can
cause carcinogenesis as the ethanol in alcohol metabolizes into acetaldehyde, which
damages DNA and prevents
DNA repair.
Biologists
have generally assumed that the
damage will be proportional to the dose, but in vitro studies
have shown that cells can repair modest
DNA damage caused by radiation — and that low - dose radiation might even protect the cell against future exposure.
Cho said previous research
has suggested that alcohol can
cause carcinogenesis as the ethanol in alcohol metabolizes into acetaldehyde, which
damages DNA and prevents
DNA repair.
About 5 % of patients with colorectal cancer that
has spread to other organs
have a flaw in the genes that repair their tumors» cancer -
causing DNA damage.
«We
have established that components in thirdhand smoke do
cause DNA damage,» said Hang.
A high dose of ActD
has been reported to
cause DNA damage and suppress transcription from all three classes of RNA polymerases, and ActD at a low dose
has been reported to selectively block RNA poly I - dependent transcription [19].
They
've also been shown to help decrease
DNA damage by reducing inflammation (the underlying
cause of many diseases) and reactive oxygen species.
Free radical
damage caused by electron - seeking, highly reactive, oxidative molecules
has been identified as the source of many maladies through mechanisms such as inhibition of telomerase, changes to cellular permeability and
DNA damage.
Some of these dyes, like Red No. 3,
have been found to
cause damage to the
DNA in human liver cells and to disrupt the function of the thyroid.
They
have been characterized as «marauders» in the body for they attack cell membranes and red blood cells and
cause damage in
DNA / RNA strands, thus triggering mutations in tissue, blood vessels and skin.
Even though there's only 5 milligrams of vitamin C in a small apple, it
has the antioxidant equivalent of 1,500 milligrams of vitamin C. I
've reviewed before how taking that much vitamin C straight in a supplement might actually
have a pro-oxidant effect, and
cause DNA damage.
Fact is, toxicological studies of the effects of algae (primarily spirulina) consumption on humans and animals, including feeding as much as 800mg / kg, and replacing up to 60 % of protein intake with algae sources,
have shown no toxic effects, and in contrast, algae intake
has actually been found to prevent
damage caused by toxins that affect the heart, liver, kidneys, neurons, eyes, ovaries,
DNA, and testicles.
While it is true that cancer cells may
have DNA damage, it is highly unlikely that
DNA damage can
cause any cell to become cancerous.
DNA damage has been shown to
cause cancer and lead to depletion of stem cell pools + it also plays a role in the aging process.
Due to the presence of nourishing phytochemicals, kiwi
has the ability to protect the
DNA from the oxidative
damage caused by the free radicals thereby, reducing the risk of development of associated inflammations and diseases.
Cooked meats in general may
cause DNA damage and
have been linked with increased breast cancer risk.
Astaxanthin
has proved itself as a strong UVB absorber and is able to reduce
DNA damage that
causes cell and collagen degradation in the human skin, which can result in premature aging, hyperpigmentation, wrinkle formation, erythema, and skin cancer.
«The risk factor we
have identified is in a gene known to repair UV -
caused damage to
DNA,» said Dr. Bellone.
Aguayo told TreeHugger that in studies of human cell cultures, potassium bromate
has been seen to
have a genotoxic effect, or in other words,
causes damage to the cell's
DNA.