Sentences with phrase «dna damaging effects»

Not exact matches

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

«Interestingly, we also found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA,» says first study author Luisa Cimmino, PhD, an assistant professor in the Department of Pathology at NYU Langone Health.

But some clinical trials have suggested that such antioxidants, which sop up DNA - damaging molecules called free radicals, have the opposite effect and raise cancer risk in certain people.

Before moving on to human trials, they will need to study all instances of «off - target» effects: Years before Crispr, the viruses employed to deliver DNA in gene therapy trials occasionally damaged the whole system, causing cancer.

Called the «bystander effect,» the findings led to speculation that the radiation was creating some agent in the cytoplasm — an unidentified chemical — that then damaged nuclear DNA.

Part of the reason for this uncertainty is that it is very difficult to knock - out non-coding RNA without damaging the DNA, which can lead to off - target effects and false results.

The same effect was observed when cells with DNA damage were treated with the drug «rapamycin,» which inhibits metabolic signalling and therefore mimics nutrient starvation.

Studies have shown that temperature can induce damage in the deoxyribonucleic acid (DNA) of plant cells, and has a profound effect on plant development and growth.

To explore the role of DNA repair in translocation formation, the researchers inhibited key components of the DNA damage response machinery within cells and monitored the effects on the repair of DNA breaks and translocation formation.

«Most antibiotics have their effect, directly or indirectly, by causing damage to bacterial DNA, so finding ways to cripple DNA repair would represent a significant advance in the treatment of resistant infections,» says senior study author Evgeny Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology, NYU Langone.

Now, researchers have developed tools to study these ephemeral molecules in small quarters of the cell, and using these techniques, have shown that the cell manages the conflicting effects of ROS by sequestering the molecule to tiny compartments or nanodomains where it acts locally, without damaging surrounding organelles or DNA.

As part of the international EU project «SPICE II Plus,» which is now coming to an end, scientists from the MedUni Vienna's Institute for Cancer Research have now also found evidence that synthetic substances damage the DNA of human cells and can therefore possibly have cancer - causing effects.

When such DNA damage occurs, proteins known as PARPs move to the site of damage and begin to mend these broken strands of DNA, allowing cancerous cells and tumors to recover, grow and proliferate, thereby escaping the effects of treatment.

The effect of ancient DNA damage on inferences of demographic histories Axelsson, E., E. Willerslev, M. T. P. Gilbert, and R. Nielsen.

The effect of ancient DNA damage on inferences of demographic histories.

The Effect of a DNA Damaging Agent on Embryonic Cell Cycles of the Cnidarian Hydractinia echinata.

The team's findings suggest that restoring proper neuronal communication is important for staving off the effects of Alzheimer's — perhaps by maintaining the delicate balance between DNA damage and repair.

If nuclear DNA damage was removed, such as via the somewhat distant molecular nanomachinery of chromallocytes, programmable nanorobots moving from cell to cell to fix each breakage, then aside from the elimination of cancer, would it have any other measurable effect on health and longevity?

Research Paper In vitro single - strand DNA damage and cancer cell cytotoxicity effects of Temozolomide Shruti Purohit, Devashree Jahagirdar, Azad Kumar, Nilesh Kumar Sharma Oncomedicine 2017; 2: 102 - 110.

Furthermore, its preventive effects against oxidative stress and DNA damage are well described [6].

These off - target effects may actually be beneficial in treating IBD, primary sclerosing cholangitis, primary sclerosing cholangitis / IBD - related CRC, and asthma, whereby a multitude of abnormal signaling involving inflammation, oxidative damage, DNA damage, and apoptotic abnormalities exists to manifest itself into a diseased state.

However: at present there is no compelling causal evidence to show that nuclear DNA damage alone has a significant effect over the present human life span in comparison to other contributions to degenerative aging.

Previous research has shown that these effects include changes in metabolism, blood pressure, and cholesterol; and animal studies have shown that practices like yo - yo dieting can damage DNA.

But you really don't even need to read the BioInitiative Report or any of the other science out there showing cellular DNA damage, blood viscosity effects, etc of EMF's.

This effect is achieved by the lowering of blood pressure in cases of diabetic patients, decreasing oxidative stress on the sensitive sperm cells and therefore minimising damage to their DNA cargo4.

To determine whether or not the damaging effects on cancer cells would affect normal cells — which are already programmed normally for apoptosis — they doused both cancerous liver cells and normal liver cells with CVE to examine the process of inducing apoptosis, which involves creating DNA damage as a precursor.

And a growing body of research links ibuprofen to adverse health effects, including increased risk of heart attack and stroke, gastrointestinal complications including ulcer, acute kidney failure, anemia, DNA damage, hypertension, and miscarriage.

They are highly reactive forms of oxygen whose effects can damage cell membranes and other structures in the body, including DNA and collagen.

We've added a biomarker, 8 - Hydroxy -2-deoxyguanosine (8 - OHdG), which measures the effect of endogenous oxidative damage to DNA and estimates risk for various cancers and degenerative diseases.

Even though there's only 5 milligrams of vitamin C in a small apple, it has the antioxidant equivalent of 1,500 milligrams of vitamin C. I've reviewed before how taking that much vitamin C straight in a supplement might actually have a pro-oxidant effect, and cause DNA damage.

Fact is, toxicological studies of the effects of algae (primarily spirulina) consumption on humans and animals, including feeding as much as 800mg / kg, and replacing up to 60 % of protein intake with algae sources, have shown no toxic effects, and in contrast, algae intake has actually been found to prevent damage caused by toxins that affect the heart, liver, kidneys, neurons, eyes, ovaries, DNA, and testicles.

Viewing cancer as a metabolic disease — opposed to a disease of damaged DNA, which is a downstream effect of mitochondrial dysfunction — gives us the power to control this dysfunction by carefully choosing foods and nutrients and employing strategies that help optimize the biochemical pathways that suppress cancer growth while simultaneously stimulating mechanisms to push it into remission.

STUDY ONE — this human study observed that grape juice had a cancer - protective effect and defended DNA against damage and that the effect was due to a lowering of blood free radicals.

The animal protein activates an enzyme that damages DNA as a side effect.

«These findings suggest that short - and long - term watercress ingestion has potential antioxidant effects against exercise - induced DNA damage and lipid peroxidation.»

Our risk of DNA damage through pesticide exposure by eating conventional produce is outweighed by the anti-cancer effects of eating more fruits and vegetables.

Mushrooms have quite an array of beneficial properties: Studies on different types of mushrooms have found anti-inflammatory effects, enhanced immune cell activity, prevention of DNA damage, slowed cancer cell growth, and angiogenesis inhibition.

The plant needs the sun's energy to grow, but it must also try to protect itself from the DNA - damaging effects of UV radiation.

«Many of the carcinogens present in mainstream smoke are known to exert their effects through a genotoxic mode of action, which is based on their ability to induce DNA damage and mutations, although an epigenetic mode of action, e.g., through aberrant DNA methylation and histone modifications, is also beginning to emerge for a few of these carcinogenic compounds.»

Aguayo told TreeHugger that in studies of human cell cultures, potassium bromate has been seen to have a genotoxic effect, or in other words, causes damage to the cell's DNA.

Criteria Description PRIORITY Carcinogenicity Potential to cause cancer Endocrine Disruption Potential to negatively effect hormone function and impact development Mutagenicity Potential to damage DNA Teratogenicity Potential to harm fetus Reproductive Toxicity Potential to negatively impact reproductive system ADDITIONAL Acute Toxicity Potential to cause harm upon initial, short term exposure Chronic Toxicity Potential to cause harm upon repeated, long - term exposures Irritation of Skin and Mucous Membranes Potential to irritate eyes, skin, and respiratory system Sensitization Potential to cause allergic reaction upon exposure to skin or airways Other Any additional characteristic (e.g., flammability, skin penetration potential, etc.) relevant to the overall evaluation but not included in the previous criteria