Sentences with phrase «dna during replication»

«The role of the protein Rrm3 in the repair of breaks in DNA during replication.»

One might well expect that accidental changes in DNA during their replication would be deleterious to the organism that harbors the changed DNA.

Not exact matches

Telomeres are repetitive stretches of DNA that cap natural chromosome ends to protect them from being damaged or fused together during DNA replication.

Telomeres provide protection to chromosomes during the replication process to prevent the loss of DNA strands.

Genes encoding ribosomal proteins, DNA replication and repair machinery, oxidative stress, and purine biosynthesis were differentially expressed in Wolbachia during the development of B. malayi female worms, suggesting a role of the bacteria in worm reproduction.

This group also clarified that Shugoshin controls DNA replication (the process by which DNA makes a copy of itself during cell division) in subtelomeres as well as higher - order structure of chromosomes.

This is because during replication, DNA polymerase can only synthesize DNA in a 5 «to 3 «direction and can only do so by adding polynucleotides to an RNA primer that has already been placed at various points along the length of the DNA.

This suggests that random errors occurring during DNA replication in normal stem cells are a major contributing factor in cancer development.

Previous research had shown that Topisomerase II was involved in earlier cellular processes like DNA replication, and the enzyme was still detectable even during later phases of meiosis.

During meiosis, the genome of a diploid germ cell, which is composed of long segments of DNA packaged into chromosomes, undergoes DNA replication followed by two rounds of division, resulting in haploid cells called gametes.

The shortening of telomeres is a process that occurs naturally in the body each time that a cell divides: during cell division the DNA, which is tightly packaged into chromosomes, must be duplicated but the DNA - copying machinery design itself, prevents the full replication of the ends of the chromosomes.

During this stage, the replication forks can meet obstacles that cause their blockage or even the appearance of breaks in the DNA.

A research group from the University of Seville has revealed the role that the protein Rrm3 plays in the repair of breaks that occur during the replication of DNA, by using the yeast Saccharomyces cerevisiae as a model organism.

To monitor such changes, they isolated DNA at several time points during the replication and repair process, and quantified the bound proteins using mass spectrometry based proteomics.

The mergers occur during DNA replication, when matching segments of otherwise disparate genes mistakenly pair up.

Holstege says the other remarkable finding was that the mutations within the blood cells were harmless — all resulted from mistaken replication of DNA during van Andel - Schipper's life as the «mother» blood stem cells multiplied to provide clones from which blood was repeatedly replenished.

An efficient unfolding of these structures is necessary in order to secure the integrity of the genome during DNA replication,» says Nasim Sabouri.

Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes errors in DNA replication, as well as problems with chromosome segregation during cell division.

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body's repair mechanism.

Based on the nucleotide context, the authors suggest that a new mutational mechanism may be at work involving cytosine deamination of single - stranded DNA (presumably during replication).

Joshua - Tor is also well known for her work on the E1 helicase enzyme, which acts to unwind DNA strands during the DNA replication process.

In a previous paper, the team showed that without the protein coded by the BRCA1 gene, DNA is not packaged properly, becoming fragile and more likely to break during DNA replication.

They discovered that this region is prone to errors during DNA replication, resulting in expansion of the polyglutamine tract.

DNA is constantly exposed to a variety of damaging factors such as genotoxic agents, environmental factors (e.g. UV light, irradiation) or normal metabolic activities (e.g. nucleotide misincorporation during DNA replication, reactive oxygen species) that causes a range of lesions.

That poses an obvious problem during S phase: While DNA replication machineries («replisomes») zip along the chromosomes trying to faithfully duplicate the entire genome in a matter of just a couple of hours, they encounter — on average — multiple cohesin rings that are already wrapped around DNA.

The Mattiroli group studies chromatin dynamics during DNA replication to understand how the epigenetic information is faithfully propagated during cell division.

Moreover, given that point mutations are acquired through DNA copy - errors (and / or failure of DNA damage repair mechanisms) during replication, preferentially within the paternal germline, a detailed knowledge of these basic biological processes is key to understanding the patterns of nucleotide substitutions.

CAF - 1 orchestrates histone deposition and nucleosome assembly during DNA replication.

Nucleosomes are disassembled and reassembled during DNA replication to ensure a faithful copy on each daughter strand.

Some bacteria have a loop of DNA, and two interlocking rings of nucleic acid can appear as an intermediate during cell replication.

The Knipscheer group studies these processes during active DNA replication in Xenopus egg extracts.

Scientists find a new role for RNAi protein Dicer in preventing collisions during DNA replication...

During the DNA replication process, telomeres keep the DNA together (like how the plastic caps on the end of shoelaces keep them from unraveling).