Developed first
DNA gene chip for horses housing 3,200 expressed horse genes, helping uncover key differences in genes between humans and animals, giving critical information before launching into an experiment
Not exact matches
So scientists can now use the so called
gene chips to scan people's
DNA for hundreds of thousands of
genes and different variants of
genes.
Now two research teams have spotlighted the middle ground, using so - called
gene chips to evaluate millions of bases of
DNA in a single experiment.
DNA microarrays, also called
DNA chips, have stoked excitement in the research community because they can test the activity of many
genes at once.
Services include global and
gene - specific
DNA methylation analysis, and chromatin immunoprecipitation (
ChIP) followed by library preparation in a high - throughput format (HT
ChIP - Seq).
Next, they extracted the
DNA from developing and mature heart cells, using an advanced
gene - sequencing technique called
ChIP - seq that lets scientists «see» the epigenetic signatures written in the
DNA.
High - throughput
ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein -
DNA interactions alter Epigenetic profiles and subsequent
gene expression.
With the development of
DNA microarrays, the
gene chips that allow scientists to read the output of thousands of
genes at once, along with robotics and computers, scientists tear through hefty analyses with previously unheard - of swiftness.
June 4, 2015 New tool brings standards to epigenetic studies One of the most widely used tools in epigenetics research — the study of how
DNA packaging affects
gene expression — is chromatin immunoprecipitation (
ChIP), a technique that allows researchers to examine interactions between specific proteins and genomic regions.
The resource provides services including: processing of the samples (cells or tissues) to make high quality chromatin for
ChIP,
ChIP with a set of validated antibodies for histone marks (Promoter marks: H3K4me3 and H3K27me3, Enhancer marks: H3K4me1 and H3K27ac,
Gene body marks for transcription activity: H3K36me3 and H3K79me2, and Heterochromatin mark: H3K9me3),
ChIP with investigator preferred custom antibodies, and library preparation from
ChIP DNA and multi-plexing for high - throughput
DNA sequencing.
Scientists used
gene chips containing feline single nucleotide polymorphisms (SNPs)-- variations from the common feline
DNA sequence that can help track down
genes responsible for genetic diseases — to conduct their investigations.
This will include robotic
DNA extraction, genome - wide mapping with high density
gene chips (querying 175,000
DNA markers), and next - gen sequencing of the entire genome of an affected dog (interrogating every letter of the 2.4 billion letter genetic code).